The Pastore Podcast

Dr. Pastore covers the typical nutritional deficiencies the newly diagnosed celiac patient may experience, the mistakes practitioners make when attempting to correct these deficiencies, and what YOU can do to be your own health-care advocate.

He then explains why those with celiac diseases (following a gluten-free diet or not), or even those with a gluten intolerance are more at risk to pneumococcal infections such as bronchitis, sinusitis, meningitis, and sepsis and what you can do to prevent this.

https://drrobertpastore.com/blog

Blood test names:

Vitamin D: 25-hydroxy vitamin D

Magnesium: Magnesium, RBC

Omega 3 fatty acids (EPA/DHA): EPA/DHA plasma & red blood cell membrane analysis

Zinc: Serum or plasma zinc concentration

Iron: Serum Iron & Transferrin & TIBC (total iron binding capacity)& UIBC (unsaturated iron-binding capacity) & Serum ferritin

Food sources for each vitamin/nutrient/mineral:

Iron: https://ods.od.nih.gov/factsheets/Iron-HealthProfessional/

Magnesium: https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/

Zinc: https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/

Choline: https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/

Vitamin D: https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/

Omega 3 EPA: https://ods.od.nih.gov/pubs/usdandb/EPA-Content.pdf#search=%22omega%203%22

Omega 3 DHA: https://ods.od.nih.gov/pubs/usdandb/DHA-Content.pdf#search=%22omega%203%22

(Part 2 of 2)

Dr. Pastore and Lexie dive into what is happening to the brain chemically in the days, weeks and months after a concussion and why these neurological changes cause concussion symptoms including loss of consciousness, laps in memory, fatigue, anxiety, memory, food cravings and even catching a cold.

Links mentioned:

poweronpoweroff.com

[Part 1 of 2]

Dr. Pastore and Lexie introduce concussions and traumatic brain injuries (TBI) - including what causes a concussion, the common symptoms, recovery time, and what to do to recover as quickly and efficiently as possible.

Stay tuned for a more in-depth look at "The Neurochemistry of Concussions" next episode.

Links mentioned:

Light therapy tools:

https://www.usa.philips.com/c-m-pe/light-therapy

Physical exercise for concussion recovery:

http://www.eldoamethod.com/about

Lexie and Dr. Pastore cover all things poop-related, including how food is turned into poop, what's normal & what's not.

They discuss constipation, gas, diarrhoea, laxatives, fecal transplants and warning signs for when you should book an appointment with your doctor to discuss your digestive health.

Infertility may be the one and only symptom that a woman OR man has undiagnosed celiac disease - there may be no gastrointestinal distress or typical "digestion" symptoms you'd assume to be present.a

Dr. Pastore discusses the most recent study around celiac disease research and then dives into the studies around infertility in celiacs, and how for Dr. Pastore's celiac patients, following a gluten-free diet led to a 100% success rate for a couple to be able to conceive.

Infertility & Celiac Disease:

https://drrobertpastore.com/blog/2019-08-28-could-your-infertility-be-a-symptom-of-celiac-disease

What to do if you think you have celiac disease:

https://drrobertpastore.com/blog/2019-08-26-what-do-you-do-if-you-think-you-may-have-celiac-disease/

Comorbidity is the presence of one or more additional medical conditions co-occurring with a primary condition.

Dr. Pastore discusses the most common comorbidities (disorders and diseases) that are connected with celiac disease and the research that uncovers why this is the case. He also elaborates on the intestinal epithelial barrier, it's importance for immunity and how gliadin (the protein found in gluten) reacts with zonulin to causes tight junction dysfunction in the small intestine.

-People with the diseases/disorders discussed may be at a higher risk of having celiac disease

-Celiac disease may be causing the signs/symptoms of other medical conditions and those may be reduced/eliminated once going gluten-free

-Those that know they have celiac disease should also be tested for the mentioned medical conditions, especially if there is a family history

Articles mentioned:

Celiac Disease: High Risk Groups, Related Disorders and Comorbidities

https://drrobertpastore.com/blog/2019-09-12-celiac-disease-high-risk-groups-related-disorders-and-comorbidities

What do you do if you think you may have celiac disease

https://drrobertpastore.com/blog/2019-08-26-what-do-you-do-if-you-think-you-may-have-celiac-disease

Dr. Pastore discusses the topic of obesity and the newest emerging studies showing it as one of the most common symptoms of undiagnosed celiac disease.

He explains the misconception that undiagnosed celiac patients would appear underweight due to malnutrition; as well as what is physiologically happening in the gastrointestinal tract and throughout the body for those that present obesity as a symptom.

Dr. Pastore's articles mentioned in the podcast:

Celiac Disease: A Clinical Chameleon

https://drrobertpastore.com/blog/2019-08-19-celiac-disease-a-clinical-chameleon

What do you do if you think you may have celiac disease?

https://drrobertpastore.com/blog/2019-08-26-what-do-you-do-if-you-think-you-may-have-celiac-disease

The Celiac and Obesity Connection

https://drrobertpastore.com/blog/2019-08-30-the-celiac-and-obesity-connection/

Dr. Pastore and Lexie cover how certain variations of specific genes can affect your performance, your nutrition, your cravings and even how food tastes.

In-depth topics include how genetics affect:

• High carbohydrate consumption and low HDL cholesterol levels
• How food tastes, and why some people can never get enough sugar
• How your risk for tendon/ligament/joint injury is increased/decreased
• Over-eating and difficulty losing weight

Genetic SNPs covered in the episode:

KCTD10-GG

MMAB-GG

MVK

May cause low HDL ("good") cholesterol levels with high carbohydrate consumption (~231g+ per day)

SLC2A2 rs5400 - T allele (even just one)

"Sweet tooth" gene, linked to over-eating, not feeling satisfied after sugar consumption, less sensitive to feeling the affects of high glucose levels in blood

TAS1R3-AA

TAS1R3-GA

Sugar tastes less sweet, increases the likelihood over overconsumption of sugar and artificial sweeteners

TAS2R38-C allele

TAS2R38-G allele

Do not like the taste of bitter foods (coffee, broccoli, kale, Brussels sprouts), over-salt or sweeten foods to cover up the taste

TAS2R38-TT

Find bitter foods less bitter than other people (enjoy broccoli, cabbage, kale, etc)

COL5A1-TT

Decreased elasticity and range of motion in joints. Increased risk of injuring joints, connective tissue (tendons/ligaments) and soft tissue.

COL5A1-CC

Protective genotype, reduced rate of tendon injury

COL1A1-TT

Decreased risk of injuring joints, connective tissue (tendons/ligaments) and soft tissue.

GDF5-T allele

Increased risk for joint injuries, can be a warning sign of early (mid-40's) onset osteoarthritis

MC4R-C allele

KCDT15-C allele

Increases likelihood of higher BMI (from fat mass), slows the process of weight loss, can cause more cravings for higher caloric/processed food intake

COMT-GG

Increases the likelihood to overeat

SHTB2, LEP, PCSK1-2, and FTO are currently being researched for their connection to obesity.

Dr. Pastore and Lexie review diabetes, Alzheimer's disease, why the emerging scientific evidence is showing that Alzheimer's disease may be Type 3 diabetes, and what you can do NOW to decrease the likelihood of developing these diseases.

Some important facts:

Prolonged elevated glucose (blood sugar) levels damage blood vessels in the brain, disrupt neurotransmitters, and cause brain cell inflammation and neuronal cell death.

Type 2 diabetes increases the likelihood of developing Alzheimer's later in life.

30% of the population carries the APO-E4 gene, those with 2 copies - increase the likelihood of those individuals developing cardiovascular disease, type 2 diabetes and Alzheimer's.

Online Order for Genetic Testing:

https://www.23andme.com/dna-health-ancestry/

Triglyceride and Glucose Index to determine Insulin Resistance:

https://www.mdapp.co/tyg-index-calculator-359/

BMI Calculator:

https://www.nhlbi.nih.gov/health/educational/lose_wt/BMI/bmicalc.htm

For fish/seafood mercury levels, click "Show Full Table" here:

https://www.ewg.org/research/ewgs-good-seafood-guide/executive-summary

Dr. Pastore and Lexie discuss emerging foods in society today, including:

-The artificial sweetener allulose, how it's made and why you should be mindful of dosages

-Plant-based "meats" such as the Impossible Burger & Beyond Meat, their protein quality and the downsides to how they are made & processed

-An up & coming plant-based protein source high in nutrients with a full amino acid profile known as duckweed