The #PDExchange Podcast

Drs Jeff Perl and Nikhil Shah, welcome you to the 8th episode of PD Exchange.

(on a side note - we now have >1000 plays and are listed by FEEDSPOT among the top 10 dialysis podcasts on the web! - thanks to YOU, our listeners)

This episode is a gem! We are grateful to Prof. Edwina Brown (ISPD President) and A/Prof Yeoung Jee Cho (PDI Deputy Editor in Chief), along with author Dr. Melissa Cheetham, for coming together to discuss the many facets of the patient-centred INCREMENTAL PD or more like PERSONALIZED PD as Prof Brown calls it.

The September issue of PDI has four articles on Incremental PD - 2 editorials and two studies.

Current PDI Issue - https://bit.ly/PDICurrent

Links to the articles -

Welcome to the Peritoneal Dialysis International Abstract Podcast.

Here, we are trying to bring the Table of Contents and the Abstracts from the most recent issue of Peritoneal Dialysis International.

We have tried to use AI-generated speech from the abstracts.

We have made minor changes to the abstracts to make listening easier. We would love to get feedback on this format of receiving PDI highlights.

Current Issue Link - bit.ly/PDICurrent

Feedback - Nikhil Shah - [email protected]

Your hosts Nikhil and Jeff discuss the PD catheter-related infection recommendations with Prof KM Chow and Prof David Johnson the lead authors for these recommendations. Both authors provide deep insight and rationale behind the suggestions and guidance on managing this common problem.

Full text #OpenAccess - https://journals.sagepub.com/doi/full/10.1177/08968608231172740

Accompanying Editorials -

For any questions, comments or suggestions - please reach out to us on Twitter - Nikhil (@dr_nikhilshah) Jeff (@PD_Perls) or email : [email protected]

Drs Oberg and Fraser along with Drs Perl and Shah discuss the exciting experiments regarding Phloretin (a GLUT blocker derived from apples!) and Phlorizin (a SGLT2 and SGLT1 blocker) and its potential use in Peritoneal Dialysis. 

PDI paper link - Dual SGLT1/SGLT2 inhibitor phlorizin reduces glucose transport in experimental peritoneal dialysis - Giedre Martus, Karin Bergling, Carl M Öberg, 2022 (sagepub.com)

JASN paper link - Phloretin Improves Ultrafiltration and Reduces Glucose Absor... : Journal of the American Society of Nephrology (lww.com)

Questions of suggestions please reach out to Drs Nikhil Shah (https://twitter.com/dr_nikhilshah)  and Jeff Perl (https://twitter.com/PD_Perls) via Twitter or write to [email protected]

Outcomes of PD for AKI treatment during COVID-19 in New York City: A multicenter study

Drs Maryann Sourial and Wei Chen discuss their experience of starting an acute PD program for AKI in New York at the height of the pandemic dealing with the massive patient influx and limited resources. 

For any questions, suggestions tweet us at - Nikhil Shah (@dr_nikhilshah) and Jeff Perl (@PD_Perls) or email us at [email protected]

Karine Manera (@KarineManera), Associate Editor for Peritoneal Dialysis International (@PDI_Journal) and patient partner Annette Spence join the #PDExchange hosts Nikhil Shah (@dr_nikhilshah) and Jeff Perl (@PD_Perls) to discuss #LifeParticipation in patients on PD which is a core outcome identified by the SONG-PD initiative (@SONG_Initiative). 

Paper:

Establishing a core outcome measure for life participation in patients receiving peritoneal dialysis: A Standardised Outcomes in Nephrology–Peritoneal Dialysis consensus workshop report - Melissa S Cheetham, Martin Wilkie, Fiona Loud, Karine E Manera, Angela Ju, Ana Figueiredo, Janine Farragher, Helen Hurst, Sarbjit V Jassal, Rajnish Mehrotra, Rachael L Morton, Daniel Schwartz, Jenny I Shen, Rachael Walker, Yeoungjee Cho, David W Johnson, Jonathan C Craig, Samaya Anumudu, Amanda Baumgart, Andrea Matus Gonzalez, Nicole Scholes-Robertson, Andrea K Viecelli, Allison Tong, On behalf of the SONG-PD Life Participation Workshop Investigators, On behalf of the SONG-PD Life Participation Workshop Investigators, 2022 (sagepub.com)

PDExchange 002 Episode Details 

At the start, Dr. Jeff Perl the Editor in Chief and Dr. Yeoungjee Cho, the Deputy Editor in Chief for Peritoneal Dialysis International, share some insight behind the editorial process for PDI. They discuss the process of selecting papers for publication in PDI and also provide some tips for researchers in the Peritoneal Dialysis world and invite them to submit their work to PDI. 

Next, we have a series of papers #EditorsChoice that Drs Perl and Cho briefly discuss. 

The links to the respective papers are listed below – 

Providing support is important to maintain a patient on peritoneal dialysis (PD), though its impact on outcomes has not been investigated thoroughly. We examined the association between having support and risk of a transfer to hemodialysis.

In this retrospective observational cohort study, we used data captured in the Dialysis Measurement Analysis and Reporting system about patients who started PD in Alberta, Canada, between 1 January 2013 and 30 September 2018. Support was defined as the availability of a support person in the home who was able, willing and available to provide support for PD in the patient’s residence. The outcome of interest was a transfer to hemodialysis for at least 90 days. We estimated the cumulative incidence of a transfer over time accounting for competing risks and hazard ratios to summarise the association between support and a transfer. We split follow-up time as hazard ratios varied over time.

Six hundred and eighty-three incident PD patients, median age 58 years (IQR: 47–68) and 35% female, were followed for a median of 15 months. The cumulative incidence of a transfer to hemodialysis at 24 months was 26%. Having support was associated with a reduced risk of a transfer between 3 and 12 months after the start of dialysis (HR3-12mo: 0.44; 95% CI: 0.25–0.78), but not earlier (hazard ratio (HR)<3mo: 0.96; 95% confidence interval (CI): 0.55–1.69) or later (HR>12mo: 1.19; 95% CI: 0.65–2.17).

A transfer to hemodialysis is common. Having a support person at home is associated with a short-term protective effect after the initiation of PD.