The 96th game ever between Chicago and Los Angeles this Sunday night under the lights on NBC. Can new Rams quarterback Matthew Stafford take the helm, the burden and raise his level of play even higher? Many including myself believes he's the missing piece to a second Rams Super Bowl team. The Bears have a championship defense again this year, their biggest question is will their offense help them more than last year?

Cleveland will visit Kansas City in week one the place where their 2021 postseason run ended a few months ago. For the 28th meeting it'll be MaHomes vs. Mayfield, a restocked Browns defense vs. A reestablished Chiefs offensive line. Who'll best who in this game? Yet another week one game that should've been in primetime if you ask me. But who am I? 348-185-2 in predictions since 2019, welcome to The Prophet's Picks 3rd season of predictions!

Unfortunately this 28th meeting between these two legendary teams won't be in New Orleans. It'll be played in Jacksonville on September 12th, 2021. A game that should've been in primetime like last season. Aaron Rodgers will begin his season of "RECKONING" against the Saints, with Drew Brees retired and working for NBC Sports it's in the capable hands of Jamies Winston and no we're not eating "W's" Mr. Winston.

Meeting number 112 all time between Miami and New England. Former Alabama Crimson Tide quarterbacks face off in this game. Tua vs. The Mac! This is possibly the most intriguing, interesting game of week one. Belichick vs. Flores, who wins?

In only the 14th meeting between New York and Denver, Daniel Jones will look to decimate the Broncos defense in week one at home. But can the Giants offense be successful running the ball? The ssme qu3is posed for Denver's quarterback Teddy Bridgewater, YES Mr. Bridgewater is the starter for Denver. The 4th NFL franchise in which he's found a home and been able to start. My take? This is a good matchup and another tough one to perdict.

In the 39th matchup between these two division rivals, all things have changed and come to a head. Both Houston and Jacksonville has the following, a new head coach and a new starter at the most important position on the NFL field and that's quarterback. Predictions in week one are always tricky, let's see who does what as all eyes will be on 1st overall draft pick Trevor Lawrence for the Jags.

San Francisco has battled Detroit a total of 67 times on the gridiron. Sunday September 12th will be the 68th meeting all time. The 49ers are coming off an injury plagued disappointing 2020 season. They're about to face what will essentially be the Rams central. Detroit has former Rams players and former Rams front office personnel members. Most notably Jared Goff is leading the Lions for now that is. Will Goff lead Detroit pass 2022?

In the 12th meeting all time between Arizona and Tennessee, Kyler Murray will face off against Ryan Tannehill. The Titans are coming off a postseason lost against the Ravens and the Cardinals biggest game was the "HailMurray" play during the regular season against the Bills. Cardinals coach Kliff Kingsbury hasn't lead Arizona to the annual January tournament yet, will he this year? The road to Inglewood California begins next Sunday September 12th across the country.

Only the 28th meeting all time between Pittsburgh and Buffalo. Another week one game that should've been in the 4 o'clock window or primetime. Bith teams where in the 2021 tournament back in January. Only difference is Buffalo made it to the Conference Championship game and Pittsburgh's melodramatic season ended in the Wild, Wildcard round. These teams met on Sunday Night Football late last season as well with Josh Allen and his Bills dominating Roethlisberger and the Steelers. Can Pittsburgh obtain the revenge they seek?

Philadelphia leads Atlanta in 36 meetings all time. The 37th matchup will be played in the same city that the 36th matchup was played and won in. ATLANTA, with bith of these franchises currently in transition, which team will catch lightning in a bottle? The Falcons with a new head coach but a savvy franchise quarterback or the Eagles with a new head coach as well as a new quarterback sitting in the franchise quarterback role, for now?