The brain is the central organ of stress and adaptation to stress because it perceives and determines what is threatening, as well as the behavioral and physiological responses to the stressor. The healthy brain is resilient and responds to experiences over the lifecourse that produce epigenetic changes. The lifecourse is a “one way stress” in which there is no true reversal but redirection that occurs in response to positive or negative experiences that may be unique to each stage of life. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 35291]