In this sermon, Pastor JR Vassar addresses dealing with scoffers and mockers in the world. JR emphasizes the importance of recognizing and renouncing our own inner scoffer, avoiding accommodation of scoffers, and discerning when to disengage from those who persistently mock and reject the truth. Scripture encourages us to stay steadfast in the face of ridicule and follow God's wisdom, seeking favor in humility rather than being influenced by those who scorn the faith.