From Lex Fridman: https://lexfridman.com/demis-hassabis/
Transcripts from Karpathy's https://karpathy.ai/lexicap/0299-large.html

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00:37:13.160 
So let's go to the basic building blocks of biology

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00:37:16.960 
that I think is another angle at which you can start

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00:37:20.200 
to understand the human mind, the human body,

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00:37:22.280 
which is quite fascinating,

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00:37:23.400 
which is from the basic building blocks,

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start to simulate, start to model

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00:37:28.960 
how from those building blocks,

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you can construct bigger and bigger, more complex systems,

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maybe one day the entirety of the human biology.

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00:37:35.820 
So here's another problem that thought

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to be impossible to solve, which is protein folding.

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00:37:42.720 
And Alpha Fold or specifically Alpha Fold 2 did just that.

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00:37:48.840 
It solved protein folding.

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00:37:50.320 
I think it's one of the biggest breakthroughs,

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00:37:53.400 
certainly in the history of structural biology,

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00:37:55.140 
but in general in science,

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00:38:00.240 
maybe from a high level, what is it and how does it work?

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00:38:04.840 
And then we can ask some fascinating questions after.

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00:38:08.700 
Sure.

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00:38:09.980 
So maybe to explain it to people not familiar

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00:38:12.880 
with protein folding is, you know,

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first of all, explain proteins, which is, you know,

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00:38:16.980 
proteins are essential to all life.

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Every function in your body depends on proteins.

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00:38:21.520 
Sometimes they're called the workhorses of biology.

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And if you look into them and I've, you know,

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00:38:25.340 
obviously as part of Alpha Fold,

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I've been researching proteins and structural biology

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for the last few years, you know,

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they're amazing little bio nano machines proteins.

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They're incredible if you actually watch little videos

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of how they work, animations of how they work.

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00:38:39.000 
And proteins are specified by their genetic sequence

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called the amino acid sequence.

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Listen: https://twitter.com/sourcegraph/status/1577687896814911488

Steve's post about Sourcegraph: 

• https://about.sourcegraph.com/blog/introducing-steve-yegge
• https://www.youtube.com/watch?v=viNB7v3bgx8

Watch/listen: https://www.youtube.com/watch?v=a5vkE7mmWJ0

Listen to 3 Books: https://www.3books.co/chapters/111 (about 1hr 20mins in)

5 hour walks: https://www.youtube.com/watch?v=mp_MKrnSdaM&list=PLbsKh5N-eR063R9VopWCM_SZ5ccxhNGLm&index=26

Listen to Colin & Samir: https://overcast.fm/+6Z2pphyiU/25:00

Listen to Lenny's pod: https://www.listennotes.com/podcasts/lennys-podcast/growth-tactics-retention-M7Vx8YjC0Ei/

Listen to MFM: https://overcast.fm/+rTsWDbyUc/10:04

PG's essay http://paulgraham.com/fn.html

HN response: https://news.ycombinator.com/item?id=27194284

Listen to Cloudcast: https://www.thecloudcast.net/2022/01/2022-look-ahead-developer-careers.html

SHOW NOTES:

• Shawn’s homepage
• Temporal.io (homepage) - open source microservice orchestration
• Learning in Public - The Coding Career Handbook
• The Coding Career (community)

Topic 1 - Welcome to the show. You seem to be at the center of (or around) so many developer-centric conversations. Tell us a little bit about your background, and some of the areas you’ve been focused on. 

Topic 2 - You’re well known for The Coding Career Handbook. With so many options out there for developers, how do you frame conversations about where people should focus? 

Topic 3 - At some point, developers (like many engineers) get bored of working on the same things. Right now it seems like we’re in the middle of big changes. What should they think about the transition process? 

• Cloud distros https://www.swyx.io/cloud-distros/
• Self provisioning runtimes https://www.swyx.io/self-provisioning-runtime/ 
• Video in DevRel https://sacra.com/research/lenny-bogdanoff-milk-video-infrastructure/?highlight=ecommerce 

Topic 4 - As a developer, what are some of the best ways to get visibility of your projects? How do you find the right balance of public projects, side projects, and whatever you’re currently getting paid for (main company job)?

Topic 5 - Any tips or tricks that you’ve learned to accelerate your learning process? 

Topic 6 - How is WFH changing the developer work-life-balance?

2017 Why Hadoop is Dying: https://www.youtube.com/watch?v=QngDInV2ino

2020 Hadoop Death Roundtable: https://www.listennotes.com/podcasts/the-on-premise-it/hadoop-is-dead-the-on-PuYEm57yaqZ/

Watch the presentaiton: https://www.youtube.com/watch?v=9s-vSeWej1U
Watch the followup: https://www.youtube.com/watch?v=MfF750YVDxM