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The Tumour Microenvironment Revolution * 🎯 Spatial Ecotypes, Liquid Biopsies & Immunotherapy 🚀
🧬 Tumours are not just masses of cells—they are organized ecosystems.
A remarkable Nature study by Zhang et al. mapped >10 million spatial transcriptomes across cancers and identified 9 conserved "spatial ecotypes" within the tumour microenvironment. Even more striking: these ecotypes could be detected non-invasively from plasma cell-free DNA using deep learning.
Higher SE7/SE8 predicted better immunotherapy outcomes, while SE4 forecast resistance and poorer survival. A powerful step toward blood-based spatial oncology and precision immunotherapy. 🚀🩸🔬
Zhang W, Brown EL, Usmani A, et al. Nature. 2026. doi:10.1038/s41586-026-10452-4
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By Dr RR Baliga, MD, MBA
5
66 ratings
🧬 Tumours are not just masses of cells—they are organized ecosystems.
A remarkable Nature study by Zhang et al. mapped >10 million spatial transcriptomes across cancers and identified 9 conserved "spatial ecotypes" within the tumour microenvironment. Even more striking: these ecotypes could be detected non-invasively from plasma cell-free DNA using deep learning.
Higher SE7/SE8 predicted better immunotherapy outcomes, while SE4 forecast resistance and poorer survival. A powerful step toward blood-based spatial oncology and precision immunotherapy. 🚀🩸🔬
Zhang W, Brown EL, Usmani A, et al. Nature. 2026. doi:10.1038/s41586-026-10452-4
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