In the third episode to honor World AIDS Day, on the 1st December, we are discussing the U=U message with Professor Paul Volberding, University of California San Francisco. We touch on the recently published multicentre study: Undetectable equals untransmittable (U = U): awareness and associations with health outcomes among people living with HIV in 25 countries discuss by Okoli et al. Read the open-access paper on the Sexually Transmitted Infections website: http://dx.doi.org/10.1136/sextrans-2020-054551 .