A brief review of the history of the world shows us that there has always been a tradition of “the hand” in Middle Eastern culture, which signified the protection of God from evil (people). This tradition is also found in Jewish culture. It is not rooted in Biblical proofs, rather as an adoption of cultural norms prevalent in the Middle East.
Biblically speaking, the hand of God (1 Peter 5:6, Psalm 110:1) signifies the following: creating the universe, protection from evil people and dire situations, healing, and comfort from pain and sorrow. There are more but these are the most significant.
Theologically speaking, St. Gregory of Nyssa, one the of the three “official” theologians of the Orthodox Church, defines the hand(s) of God as Jesus Christ (right hand) and the Holy Spirit (left hand).
https://stlukemission.org/sermons/gods-hand-of-protection