"Seeking a Human Spaceflight Program Worthy of a Great Nation" presents the final report from the Review of U.S. Human Space Flight Plans Committee, which undertook an independent review of the ongoing U.S. human space flight initiatives and alternatives. The Committee's mission was to ensure that the nation was on the best trajectory for future human space flight, emphasizing safety, innovation, affordability, and sustainability. This report identifies a range of options for continuing U.S. space activities beyond the Space Shuttle era, addressing critical objectives such as developing new capabilities for the International Space Station, supporting lunar missions, and fostering commercial space flight.