In episode 6, we’re not reading tea leaves -  we’re reading saliva! Saliva is a particularly interesting series of compounds that can tell a surprisingly detailed story of a person’s health, and it can be used to test for a variety of different biomarkers which can correlate to a particular disease state, including tests for HIV antibodies, SARS-CoV-2, and even certain forms of cancer! From Yale University’s SalivaDirect protocol for Covid-19 detection to dentists looking to test for oral cancer while they fill a cavity, commonly using saliva as a convenient sample is within spitting distance!

This week, Dr. Mickey Urdea is exploring eDNA, or environmental DNA, and its uses and applications in diagnostics! Tune in to hear about wastewater testing, just how much DNA can be found outside of a zoo, and why the half-life of DNA means that we’ll never have a Jurassic Park (sorry, kids!).

In Part Two of Dr. Mickey Urdea's foray into the history of bacteria, the focus is on the history of bacterial culture, sequencing, and amplification methods, and how those developments changed how we diagnose and treat bacterial diseases! From the work of two-time Nobel laureate biochemist Fred Sanger to the most advanced sequencing panels of the present day and how they're being utilized, Part Two covers it all.

In this two-part episode of Interesting Stories in the History of Diagnostics, Dr. Mickey Urdea is discussing bacteria, and why we "Can't Live With 'Em, Can't Live Without 'Em!" Part One of this two-part series canvasses the history of bacteria from the earth's formation to the modern day, and where to find them from the bottom of the Mariana Trench to inside of our own bodies. Tune in for Part Two coming up soon to hear about the history of bacterial culture, sequencing, and amplification methods, and how those developments changed how we diagnose and treat bacterial diseases!

In the third episode of our "Interesting Stories in the History of Diagnostics" series, Dr. Mickey Urdea expounds on the history of diseases caused by helminths - aka parasitic worms! Helminth diseases still affect more than 1.5 billion people worldwide (24% of the world's population!) today, and properly testing for the presence of worms is a challenge that the diagnostics industry continues to master. From being the subject of Charles Darwin's best-selling book (really!) to being the impetus for the founding of the Rockefeller Foundation, worms have had a surprisingly significant effect on diagnostics history.

In this installment of our "Interesting Stories in the History of Diagnostics" series, Dr. Mickey Urdea chronicles the history of the use of smell in diagnostics, from Hippocrates to present day cancer-sniffing dogs (yes, really!).

In this first installment of our "Interesting Stories in the History of Diagnostics" series, Dr. Mickey Urdea shares the story of the Dynamizer, a diagnostic device from the early 20th century which parallels the rise and fall of a more modern example - Theranos.