This Pathological Life Podcast

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode **

One of the important jobs of a doctor is to prescribe medications.

Unfortunately, it also happens to be one of the most challenging.

Pharmacokinetics, physiology, and drug-to-drug interactions are just some of the challenges that doctors deal with every day.

It is becoming more apparent that for medications and one size (dose) does not fit them all. In addition, it the role of genetics is also becoming increasingly important for the drugs that suit, and don’t suit, individual patients.

Our special guest for this episode is Professor Graeme Suthers to help us shed light on this area of Pharmacogenetics.

SPECIAL GUEST

Professor Graeme Suthers
BSc (Med), MBBS, PhD, FRACP, FRCPA, GAICD

Prof Suthers is Sonic Healthcare’ Director of Genetics. He is one of Australia’s most respected experts in the field of genetics, and is nationally and internationally recognised for his expertise in genetic disorders, testing and clinical service provision.

See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode **

In the 1920’s, Pearl Buck searched for an answer to her 3 year old daughters intellectually disability.

Unfortunately, no-one could help her because her daughter's condition was not yet known.

From the mid 1930s to the 1960s, a remarkable sequence of events led to the discovery of Phenylketonuria (PKU), accurate testing and widespread screening that revolutionised early detection of childhood disease(s)

It was also around the same time (mid 1930s) that some young children were believed to be dying of Coeliac disease. One child had an unusual findings in their pancreas.

Further investigation revealed other children with the same finding.

This was not Coeliac disease, it was Cystic Fibrosis (of the pancreas). As more was learnt about this disease, children began to live longer with improved quality of life.

Over the span of 90 years, the average life expectance for a person with Cystic Fibrosis went from 6 months to close to 50 years.

Our special guest for this episode is Professor Graeme Suthers.

NB. The voice of Pearl Buck was generously recorded by Christine Helen Coombe. We appreciate all submissions via our social media request.

SPECIAL GUEST

Professor Graeme Suthers
BSc (Med), MBBS, PhD, FRACP, FRCPA, GAICD

Prof Suthers is Sonic Healthcare’ Director of Genetics. He is one of Australia’s most respected experts in the field of genetics, and is nationally and internationally recognised for his expertise in genetic disorders, testing and clinical service provision.

See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode **

The computing world has come a long way in less than 100 years.

Since Alan Turing introduced his paper ‘Computing Machinery and Intelligence’ in 1950, we have not only achieved the ‘Turing Test’ of Artificial Intelligence, but exceeded it.

This episode takes a look at Digital Pathology and the prospects of Artificial Intelligence particularly in relation to Anatomical Pathology.

Our special guest is Dr Joseph Anderson

Dr Joseph Anderson Bio
Connect on LinkedIn 

Dr. Joseph Anderson, the host of Digital Pathology Today, is a consultant to early stage and mature companies in the digital pathology and molecular diagnostics space.

Previously, he oversaw the clinical pathology group at Genomic Health as the Oncotype Dx Breast Cancer Assay grew to a volume of over half a million tests. He was also involved in the development of new products, including assays for DCIS, Colon Cancer and one of the first commercially available liquid biopsies.

He served the College of American Pathologists on the Molecular Oncology Committee, with responsibility for proficiency testing in biomarkers for lung cancer in the United States and across the world and as a member of the House of Delegates representing the State of California. He has served on several working groups and committees for the American Medical Association for CPT coding and reimbursement and assessment of new technologies such as next generation sequencing.

Upon graduating from the University of Minnesota Medical School, Dr. Anderson completed residency in Anatomic and Clinical Pathology at Rush University, fellowship in Oncologic Pathology at Fox Chase Cancer Center and post-doctoral training in Molecular Diagnostics at UCSF. He initially worked in private practice, credentialed at 17 various hospitals and surgery centers.

Digital pathology Today
Link: https://www.digitalpathologytoday.com
Digital Pathology Today™ is your podcast all about the world of digital pathology. 

 

 

See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode **

Cholesterol is an essential component of our cells.

It is synthesized by our cells and affected by dietary, lifestyle, and genetic factors.

Unfortunately, cholesterol for doctors can feel like a moving target as different guidelines have different recommendations, new measurements can appear on reports (ie Non-HDL), and it is a constantly evolving topic for research

In this episode, we talk to one of Australia’s foremost expert in Cholesterol, Professor Ken Sikaris.

This podcast is eligible for 1 RACGP CPD point – self reporting.

Associate Professor Ken Sikaris Bio

KEN trained in science then medicine at Melbourne university before becoming a pathologist in 1992. He worked for several years at St Vincent’s hospital in Melbourne including running a specialist lipid/cholesterol laboratory performing research as well as seeing hundreds of patients in the lipid/cholesterol clinic.

Since then he has worked in private pathology and currently in his job as chemical pathology director he supervises testing on thousands of patients each day - including thousands of cholesterol tests. He is well known internationally in the fields of pathology Quality and how we define the decision limits we use to interpret blood tests.

Ken has several YouTube’s on the low carb down under site (with a total of over half a million views) and some may have seen him as Professor Blood in the Australian documentary ‘That Sugar Film’.

Bio Link: https://www.mps.com.au/about-us/pathologists/assoc-prof-ken-sikaris/

YouTube: https://www.youtube.com/watch?v=OyzPEii-wo0

That Sugar Film: https://www.youtube.com/watch?v=lsnk8s6JNIQ

See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode **

“I die before my time, killed by the English oligarchy and its hired assassins.”

These are the words of Napoleon Bonaparte dictated in his last will and testament on his death bed.

Napoleon is undoubtedly one of the world’s greatest Generals.

During his life, France become a global power. The man responsible for the Napoleonic wars and had previously escaped exile before, was captured again following the defeat at the Battle of Waterloo and exiled a second time to the island of St Helena in the Pacific.

The official cause of death concluded by an autopsy was stomach cancer.

However, his death is surrounded by controversy.

1. Did the British have him killed?
2. Was he poisoned with arsenic?
3. Was his body swapped before or after his death?

In this episode we discuss the life & death of Napoleon Bonaparte, gastric cancer and some of the conspiracy theories surrounding the Great General’s demise.

See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode **

Multiple Endocrine Neoplasia is a difficult diagnosis for patients, families, and clinicians.

The vast array of symptoms, affected organs, and complex genetics often mean that it can take years (if not longer) for it to be diagnosed. In addition, the impact for the patient is significant as it is a familial disease that is autosomal dominant with very high penetrance.

These syndromes were only identified around the 1960s. However, clinical suspicions were unable to be confirmed as the molecular/genetic techniques only in its infancy. It is a rare condition but one that is critical to recognise early to ensure we provide the best care and management for patients and their families.

Special Guest
Mark A. Lewis, MD, is director of gastrointestinal oncology at Intermountain Healthcare in Utah.

Specializing in cancers of the gastrointestinal tract and accessory organs, his interests focus on hereditary cancer syndromes and young-onset cancers, shared decision-making, and patient-physician communication.

The death of his father not only took a huge emotional toll on Lewis, but also piqued his intellectual curiosity. Lewis’ paternal uncle and grandfather both died of rare cancer types and then Lewis was diagnosed with a suspicious symptom himself – hypercalcemia, or high levels of calcium – something his father had also experienced.

As Lewis completed his medical training and established his current position as a haematologist/oncologist at Intermountain Healthcare in Utah, his PNETs were serially monitored. After the dominant PNET changed, crossing a threshold of concern, he had surgery and has documented the experience. Lewis had another special person in mind though and says, “I wanted my son, who has inherited MEN1 from me and may one day require pancreatic surgery himself, to have a record of my own operation.”

Quote: “Pancreatic cancer need not be viewed as a death sentence.”

REFERENCE
pancan.org/news/quest-understand-fathers-illness-young-doctor-discovers/

See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode **

Coeliac disease has been recognised since the times of Ancient Greece.

This is a malabsorption disease that causes abdominal pain, nausea, vomiting, bloating, diarrhoea, and leaves sufferers starved of nutrients.

The offending protein is Gluten which is found in wheat, rye, and barley.

It was a Dutch Paediatrician by the name of Dr Willem Dicke who discovered the link between Gluten and Coeliac disease around the 1940s. This arose from the keen observation of a young patient’s mother to the devastation and starvation of the Hunger Winter in World War 2.

This is a story like no other.

See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode **

Leprosy the disease, is rife with myths and false beliefs.

In 1863, Hawaii recognised leprosy an official public health threat. In 1865, a law of segregation was enacted forcing sufferers to Kalaupapa on Molokai island.

As fate would have it, St Damien of Molokai (canonized in 2009) was there to serve.

His role was that of a model Priest and his feats were super-human. However, local legends are not always a perfect reflection of historical events, and Damien the man can be lost in St Damien the hero.

Leprosy is a terrible disease but it is much less contagious than commonly thought.

Its historical significance may have heightened due to inter-language Biblical translation over centuries. In any event, it is a fascinating disease and one worth knowing more about.

See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode **

Lead has been used for thousands of years.

And why not? This is a metal that is abundant, pliable, has a low melting point, and does not easily corrode. However, even our ancestors knew that those who worked closely with it often became sick.

Called Saturnism by the Ancient Romans, lead poisoning was known to cause a pale appearance, intestinal problems, paralysis, delirium, and even death.

We have not escaped the perils of lead in our modern times.

Petrol, paint, construction, ammunition, cosmetics, toys, etc. have at all included lead at some point in time. Recent regulations have reduced the exposure of the general population. However, we are not immune from contamination and outbreaks as recent history has shown.

GUEST INTERVIEW

This episode includes an interview with special guest, Dennis Strenk, Milwaukee Pathologists' Assistant, CFO and Board of Trustees member of the AAPA and People of Pathology Podcast host [peopleofpathology.podbean.com]

See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode **

In June 1981, the CDC reported an article of 5 men who presented with Pneumocystis pneumonia (PCP). PCP is an opportunistic infection more commonly found immunosuppressed patients (ie. patients receiving chemotherapy for cancer).

The 5 men were young and otherwise healthy.

They were also all homosexual.

In July 1981, another CDC article reported 26 men who presented with PCP as well as Kaposi sarcoma. Kaposi sarcoma is a rare blood vessel tumour. This could not be a coincidence and the world was on the precipice of a pandemic that would kill millions and unleash a wave of homophobia, prejudice and demonization.

Fortunately, today, HIV is a manageable disease and patients can continue to live productive and healthy lives which could not be further from this once terminal diagnosis.

This is the story of HIV.

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