Thrivous

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Thrivous episodes

October 25, 2022 Combine These Supplements to Enhance Cognitive Performance
Scientists have studied the interaction between Vitamin B supplements and Omega 3 fatty acids with respect to cognitive health. Cognitive health is defined by the National Institute on Aging as “the ability to clearly think, learn, and remember.” Persons with elevated homocysteine levels tend to exhibit relatively poor cognitive performance. It has been suggested that Vitamin B supplements could lower homocysteine levels and thereby slow down cognitive decline. It has also been suggested that the efficacy of Vitamin B is dependent on Omega 3 fatty acid, becoming effective in individuals with higher Omega 3 plasma levels. These suggestions, however, haven’t been unanimously accepted. And that motivated scientists to conduct a thorough study based on extensive data. In a study published in European Journal of Nutrition, the scientists report the results of their investigation on whether the effect of Vitamin B on cognitive health depends on Omega 3 levels in cognitively healthy older adults. Rather than conducting a new trial, the scientists further analyzed data produced by the existing B-proof trial. The B-proof (B-Vitamins for the Prevention of Osteoporotic Fractures) trial collected data between October 2008 and March 2013 in the Netherlands. It investigated the effect of Vitamins B9 and B12 on bone health. However, cognitive function was measured as a secondary outcome. And the data related to cognitive health have been further analyzed in this new study. The participants in the B-proof study were men and women aged 65 years and older, with elevated plasma homocysteine levels. The participants received either intervention tablets with 400 µg B9 and 500 µg B12, or placebo tablets, for a period of 2 years. Both intervention and placebo tablets contained 15 µg of Vitamin D3. For this new study, the scientists analyzed data from 191 participants. The cognitive health of the participants in the B-proof study was assessed twice. The first assessment was at the beginning of the study. And the second was after two years of intervention. Assessments included an extensive battery of cognitive tests, administered by trained research assistants. For the new study, based on the B-proof data, the scientists further analyzed the effect of Vitamin B supplements on cognitive health as a function of Omega 3 levels. In particular, they looked at levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). After analysis, the scientists concluded that the effects of Vitamin B on the cognitive performance of older adults are related to plasma DHA levels. Higher plasma DHA levels increased the benefits of Vitamin B supplements. Thrivous develops its Clarity supplement to enhance brain function, and the Omega supplement to enhance cardiovascular function. Together in Thrivous Stack, they provide clinical doses of the most bioavailable forms of Vitamin B Complex and Omega 3, along with complementary science-backed nutrients to enhance cognitive performance and promote healthy longevity. As concluded by this study, the ingredients in Clarity and Omega can improve each other's effects when used together.
4 min
October 21, 2022 These Supplements Rapidly Reduce Pain After Exercise
Scientists have studied the efficacy of turmeric-boswellia supplements in reducing exercise-induced acute muscle and bone pain. The study is published in Medicine. Muscle and bone pain is very common. Physical exercise has beneficial effects. But strenuous and eccentric exercise comes with a cost and injuries happen. It may lead to inflammation that causes pain in the body’s joints, ligaments, muscles, nerves, tendons, and structures that support the limbs, neck, and back. Curcumin and boswellic acids are the active ingredients of Turmeric rhizomes and Boswellia serrata gum resin. They are known to inhibit some of the factors that are directly involved in inflammatory processes. Curcumin, a bright yellow chemical produced by the turmeric plant, is approved as a food additive by the World Health Organization and the U.S. Food and Drug Administration. Extracts of Boswellia serrata have been shown to enhance joint function and comfort. This study was planned to understand the effect of a turmeric-boswellia formulation on exercise-induced moderate-to-severe acute musculoskeletal pain. Researchers also aimed to confirm earlier findings on a wider statistical sample. The scientists evaluated the efficacy of a single dose of 1000 mg of turmeric-boswellia formulation in reducing exercise-induced acute musculoskeletal pain. And they analyzed pain relief and improvement in pain at resting position, with movement, and while applying pressure on the affected body part. The scientists enrolled 232 healthy participants aged 18 to 65. Half were males and half females, with exercise-induced acute musculoskeletal pain. The participants enrolled had exercise-induced pain in lower back, shoulder, knee, lower body, and other parts of the body. Half of the participants received a single-day, single-dose of turmeric-boswellia formulation. And the other half received a placebo. The scientists found a significant and rapid pain reduction in the participants who received the treatment, compared to those who received the placebo. The analgesic (pain reduction) effect of the turmeric-boswellia formulation may be due to the presence of multiple natural anti-inflammatory ingredients, which act to improve acute neuroinflammation. The scientists conclude that exercise-induced acute muscle and bone pain of moderate-to-severe intensity can be effectively relieved by a single dose of 1000 mg of turmeric-boswellia formulation in about 3 hours. This is, the scientists suggest, an effective and safe natural alternative for the management of acute pain. Thrivous develops Tenacity Arthroprotector to enhance joint and bone function and comfort for better aging. Each serving provides clinical doses of Turmeric Curcumin and Boswellia Serrata. As shown in this study, Tenacity may enhance exercise recovery. Get your Tenacity from the online Thrivous store!
4 min
October 12, 2022Thrivous Develops Serenity Nightly Nootropic Formula 3
Orem UT – Thrivous, the human enhancement company, has released Serenity Nightly Nootropic Formula 3 with KSM-66® Ashwagandha. Serenity is the advanced nootropic supplement that Thrivous develops to enhance relaxation, sleep, and next-day focus.
Serenity combines nootropic nutrients with the highest levels of evidence and the greatest magnitudes of effect, based on the best available science. The formula provides clinical doses of the following nutrients:
KSM-66® Ashwagandha (New)
L Theanine
Magnesium Glycinate
Melatonin
"Serenity has long been one of my personal favorites, both for sleep and potential anti-aging benefits," said Lincoln Cannon, CEO at Thrivous.
"I also love hearing from our customers who report that Serenity helps them fall asleep quicker, and sleep more deeply and longer. What a difference that makes the next day. And those benefits accumulate over time to improve every aspect of life."
KSM-66® Ashwagandha
Each serving of Serenity Nightly Nootropic Formula 3 provides a clinical dose of Ashwagandha. Ashwagandha is an adaptogenic herb. Multiple human studies show that supplementation promotes relaxation, among other health and performance benefits.
Serenity Formula 3 now provides the KSM-66® brand of Ashwagandha. It is the most clinically-studied and highest concentration full spectrum extract of Ashwagandha on the market.
Complementary Nootropic Nutrients
Each serving of Serenity Nightly Nootropic also provides clinical doses of L-Theanine, Magnesium Glycinate, and Melatonin.
L-Theanine is an amino acid found in various herbs. Multiple human studies show that supplementation promotes relaxation.
Magnesium Glycinate is an essential dietary mineral reacted with an amino acid. Multiple human studies show that supplementation promotes relaxation and enhances sleep quality.
Melatonin is a bioidentical hormone. Multiple human studies show that supplementation promotes sleep. Multiple human studies also show that long-term supplementation is generally safe.
Science, Quality, and Transparency
Nootropics are cognitive technology. They support healthy brain function and enhance mental ability. In pursuit of its mission, Thrivous develops advanced nootropic supplements with exceptional science, rigorous quality, and total transparency. Serenity is one of several nootropics that Thrivous develops.
Thrivous develops formulas based on the best scientific evidence from placebo-controlled human studies – the gold standard of health science. In consultation with an advisor board of physicians and scientists, Thrivous performs extensive analysis of decades of clinical research from scientists around the world. Algorithms rank hundreds of nutrients by parameters that include evidence, safety, and efficacy. And formulas incorporate only the highest-ranked nutrients and doses.
Thrivous supplements pass through multiple rounds of rigorous quality control. Suppliers test each nutrient for identity, potency, and safety from harmful microbes and heavy metals. Third-party labs test each nutrient and their combination to double- and triple-check quality and safety. And manufacturing follows strict GMP regulation from the FDA at audited and certified facilities in the United States.
Thrivous is committed to total transparency, making all science and quality documentation completely open source. Each supplement webpage provides a prominent link to download a summary of clinical studies, which summarizes and links to all scientific studies on which the supplement formula is based. Each supplement webpage also provides a prominent link to download a certificate of analysis and quality, which includes all documentation from suppliers, third-party labs, and manufacturing.
Product Resources
Thrivous makes all product, science, and quality information available at the following locations:
Product Webpage
Summary of Clinical Studies
Certificate of Analysis and Quality
About Thrivous
Thrivous is the human enhancement company. Its mission is to help people access technology with the greatest potential to improve their brains and bodies. Thrivous develops nootropics to enhance cognition and geroprotectors to combat aging. Each nutrient and each dose is based on multiple human studies. And its rigorous quality control is completely open source. For more information, contact [email protected].
About KSM-66®
KSM-66® is the most clinically-studied and highest concentration full spectrum extract of Ashwagandha on the market. KSM-66® is a registered trademark of Ixoreal Biomed Inc. Use of this product may be protected by one or more U.S. patents and other international patents.
6 min
October 11, 2022 Anthocyanin Supplements Enhance Memory
Australian researchers have found that anthocyanin in dietary supplements shows promise for memory enhancement and support of healthy cognitive aging. A paper is published in Nutritional Research. The researchers describe the result of a study that investigated the association between anthocyanin intake and indices of memory and cognition in forty older adults with mild cognitive impairment. Anthocyanins are flavonoids that provide purple, red, and blue pigmentation in fruits and vegetables, such as blueberries, plums, and cherries. Flavonoids are compounds found in plant-based foods, which have been suggested to support healthy aging of the neurological and cardiovascular systems. Flavonoids regulate blood pressure, and are thought to have anti-inflammatory and anti-oxidative action on neurons. For example, previous human studies have shown that dietary supplements containing Blueberry anthocyanin may support brain health. And supplements containing Bacopa Monnieri flavonoids may enhance memory. The objective of this study was to comprehensively investigate the effects of anthocyanin intake on memory and cognition in older adults with mild cognitive impairment. In particular, the researchers wanted to explore whether cognitive performance differed between consumers of higher and lower anthocyanin doses. Forty participants, 21 men and 19 women, were recruited to take part in an 8-week randomized controlled trial (Australian New Zealand Clinical Trials Registry ACTRN12618001184268 ). All participants were aged 50 or more, with a clinical diagnosis of possible or probable mild cognitive impairment. The primary aim of the trial was to determine whether a cognitive training intervention and anthocyanin supplements would prevent further cognitive decline or improve cognitive performance. The participants consumed different foods containing different amounts of anthocyanin. And they were split into two groups according to their average daily anthocyanin intake. The participants consuming less than 10mg per day were categorized as lower intake consumers. And those consuming more than 10mg per day were categorized as higher intake consumers. The cognitive performance of all participants was evaluated with tests like the Rey Auditory Verbal Learning Test. This is a widely used and well-validated cognitive test. It consists of five consecutive trials in which participants recall a list of 15 words that have been read aloud to them. The results of the study indicate that higher intake anthocyanin consumers demonstrated better memory retention. For example, they recalled between 2 and 3 words more than lower intake anthocyanin consumers after a short delay. Higher anthocyanin intakes were also associated with a slower rate of forgetting, with higher intake consumers forgetting around 2 words less on average after a long delay. Therefore, the hypothesis that higher consumption of anthocyanins is associated with better cognitive performance is confirmed by the study. Thrivous develops Vitality Geroprotector to promote healthy cellular and metabolic function for better aging. Each serving provides a clinical dose of Blueberry anthocyanin, as well as complementary nutrients. As demonstrated by this study, Vitality may also enhance memory retention, decrease forgetfulness, and support healthy brain function for better aging. Get your Vitality today!
4 min
October 08, 2022 Boost and Protect Cognition with Clarity and Alpha Stack
Cognition: Learn. Experience. Sense. Think. Store. Recall. Use. Act. Life revolves around acquiring information, turning information into workable knowledge, making decisions, and then acting. Information comes through mental exertion, memories, and sensory input. Our ability to learn, think, and act comes naturally. For the most part, we do not even think about the processes we go through every day. We work, drive, cook meals, play with the dog, etc. And we instinctively know where we are and our next step. I grew up playing ball. In my youth, I had an uncanny ability to read a court. Instinctively I knew how fast I was going, how quick I could turn, where the other players were, where the ball was, and where the holes in the defense were. Middle age has crept up on me. Recently, I shut the door with a flick of my left hand. A move I’ve repeated so many times, I do it without conscious thought. But this time, I shut the door on the fingers of my left hand. I shut it so hard, I ended up losing two fingernails. After I stopped jumping and hollering in pain, my thought was how could I not know in space and time where the door frame was in comparison to the timing of my hand? The only explanation that seemed reasonable was that my brain took a mini vacation. Supporting Cognition The thought of living life with reduced cognitive abilities sounds daunting. After a lifetime of working to embrace the golden years, cognitive decline can cost a great deal more than a couple of fingernails. It robs the potential to learn, experience, create, enjoy, and live life to the fullest. The best way to support cognition for healthy aging is by recognizing and embracing the fact that what you do today influences the rest of your tomorrows. Longitudinal research studies indicate cognitive decline starts much earlier than observable symptoms. Cognitive decline may begin even before we reach middle age (40-65 years). It is never too early to make healthy lifestyle choices. In fact, one research study found that “higher intake of B vitamins throughout young adulthood was associated with better cognitive function in middle life.” No matter what your age, making healthy lifestyle choices today supports active cognitive aging. A nutritional diet, appropriate sleep, exercise, and the right dietary supplements act cumulatively to reduce neurotoxins and systemic inflammation. Neurotoxins poison brain cells, neurons, and nerves. Systemic inflammation is associated with a host of health-related issues, including neurodegenerative disorders. Thrivous Clarity and Alpha Stack Doing regular chores around the house keeps the home environment pleasant and in working order. What happens if you neglect the dishes for a week? For one thing, dried gunk is harder to remove, and it takes longer to clean them. The same thing happens inside our body when toxins and inflammation build up. Thrivous Clarity and Alpha Stack is loaded with scientifically backed antioxidants and anti-inflammatories to support healthy cognitive aging. It combats neurotoxins and systemic inflammation on a biochemical level. Along with cognition and healthy cognitive aging, Thrivous Clarity helps boost mood, improve sleep quality, and reduce fatigue. Thrivous Alpha has additional ingredients that further boost cognition and healthy cognitive aging. These scientifically-backed ingredients in Clarity and Alpha Stack support: Current Cognition: Bacopa Monnieri, L Theanine, Rhodiola Rosea, B Vitamins, Alpha GPC, R Alpha Lipoic Acid, Phosphatidylserine, and Ginkgo Biloba Sleep Quality: L Theanine Fighting Fatigue: Rhodiola Rosea, B Vitamins, and Acetyl L Carnitine Mood: L Theanine, Rhodiola Rosea, and Zinc Picolinate Metabolism: B Vitamins and Acetyl L Carnitine Healthy Cognitive Aging (including protecting brain cells and neuromodulators): Acetyl L Carnitine, Alpha GPC, R Alpha Lipoic Acid, and Phosphatidylserine For individuals experiencing or concerned about cognitive issues associated with agin ...
7 min
October 04, 2022 Algae-Based Microrobots Deliver Life-Saving Drugs
Nanotechnology engineers at UC San Diego have developed microscopic robots, called "microrobots." They can swim around in the lungs, deliver medication, and be used to clear up life-threatening cases of bacterial pneumonia. "Our goal is to do targeted drug delivery into more challenging parts of the body, like the lungs. And we want to do it in a way that is safe, easy, biocompatible and long lasting," says research co-leader Liangfang Zhang in a press release issued by UC San Diego. "That is what we've demonstrated in this work." The engineers had previously developed drug-delivering microrobots that can be safely used in live animals to treat bacterial infections in the stomach and blood. Treating bacterial lung infections is the latest in their line of work. "With an IV injection, sometimes only a very small fraction of antibiotics will get into the lungs. That's why many current antibiotic treatments for pneumonia don't work as well as needed, leading to very high mortality rates in the sickest patients," adds co-author Victor Nizet. "Based on these mouse data, we see that the microrobots could potentially improve antibiotic penetration to kill bacterial pathogens and save more patients' lives." A paper is published in Nature Materials. Engineers report that the microrobots safely eliminated pneumonia-causing bacteria in the lungs of laboratory mice, and resulted in 100% survival. All mice treated with the microrobots survived past 30 days, while untreated mice died within three days. The paper explains that the microrobots are made of algae cells, whose surfaces are speckled with antibiotic-filled nanoparticles. The microrobots leverage the native movement system of the algae cells to swim around and deliver antibiotics directly to the bacteria in the lungs. The nanoparticles containing the antibiotics also contain biomaterials that absorb and neutralize inflammatory molecules produced by the bacteria and the body's immune system. This gives the microrobots the ability to reduce harmful inflammation, which makes them more effective at fighting lung infection. "These results show how targeted drug delivery combined with active movement from the microalgae improves therapeutic efficacy," summarizes research co-leader Joseph Wang. After treatment, the body's immune cells efficiently digest the algae, along with any remaining nanoparticles. Nothing toxic is left behind. The engineers are persuaded that these findings highlight the attractive functions of algae-nanoparticle hybrid microrobots for the delivery of therapeutics to the lungs in intensive care unit settings. The research work will continue with more studies to validate the microrobot treatment, scaling up before testing in larger animals, and eventually in humans. "We're pushing the boundary further in the field of targeted drug delivery," concludes Zhang. This shows that nanoparticle-based medicine is promising and could have a real clinical impact in, say, a decade or two. And it’s worth bearing in mind that the longer-term medical potential of advanced nanotechnology, as described in Eric Drexler’s classic book " Engines of Creation," is huge.
4 min
September 27, 2022 Chromosome Fusion Enables Accelerated Evolution
Chinese scientists have developed a new technique for programmable chromosome fusion. And they've used the new technique in the laboratory to produce mice with genetic changes that occur on a million-year evolutionary scale. “One of the goals in synthetic biology is to generate complex multicellular life with designed DNA sequences,” write the scientists in a paper published in Science. “Being able to manipulate DNA at large scales, including at the chromosome level, is an important step toward this goal.” Before this work, chromosome-level genetic engineering had been accomplished only in yeast. But now the scientists applied gene editing to embryonic stem cells and produced laboratory mice with 19 pairs of chromosomes, one pair fewer than is standard in this species. A press release issued by the Chinese Academy of Sciences emphasizes that the findings indicate that chromosome level engineering can be achieved in mammals. And they provide critical insight into how chromosomal rearrangements may influence evolution. “Some engineering mice showed abnormal behavior and postnatal overgrowth, whereas others exhibited decreased fecundity, suggesting that although the change of genetic information was limited, fusion of animal chromosomes could have profound effects,” says LI Zhikun, co-first author of the paper, in the press release. Li adds that the findings show that chromosomal rearrangement “is the driving force behind species evolution and important for reproductive isolation, providing a potential route for large-scale engineering of DNA in mammals.” Using CRISPR, the scientists swapped two genetic chunks of different chromosomes. Two chunks of different chromosomes were artificially fused together, explains SingularityHub, “in a daring experiment that asked: rather than tweaking individual DNA letters or multiple genes, can we retune an existing genomic playbook wholesale, shuffling massive blocks of genetic material around at the same time?” The explainer notes that gene editing is like copy editing, “changing a typo here and there, or fixing multiple grammatical errors with carefully-placed tweaks.” But chromosome-level genetic engineering “is like rearranging multiple paragraphs or shifting complete sections of an article and simultaneously hoping the changes add capabilities that can be passed onto the next generation.” “This means that, for the first time in the world, we have achieved complete chromosomal rearrangement in mammals, making a new breakthrough in synthetic biology,” said Li as reported by South China Morning Post. “This research is a breakthrough in bioengineering technology, helping to understand the impact of large-scale remodelling of mammalian chromosomes, and to gain a deeper understanding of the molecular mechanisms behind growth and development, reproductive evolution, and even the creation of a species.” The scientists are persuaded that this new technology could also help find cures to conditions like infertility and diseases like cancer, “because it lets scientists observe and control the complex activities of chromosomes in mammalian cells.” It seems clear that new discoveries and techniques in DNA engineering are piling up with an accelerating pace. And their impact is likely to be very deep.
4 min
September 20, 2022 Bioengineered Immune Cells for Deadly Genetic Disease
Immusoft, a biotechnology company based in Seattle, has announced that the US Food and Drug Administration (FDA) “has agreed to let it move forward with the first study in humans of a new type of gene therapy, using genetically engineered B cells.” The are immune system cells that make antibodies, MIT Technology Review reports. Immusoft plans to harness B cells to treat a rare inherited disease called MPS I. “I feel 100% confident in stating we are the first to get the green light to enter clinical trials,” said Sean Ainsworth, CEO of Immusoft, as reported by MIT Technology Review. A press release issued by Immusoft explains that MPS I is a rare genetic disease that affects the body’s ability to produce an essential enzyme. It results in progressive damage to tissues and organs. Children with MPS I require frequent infusions, which impacts quality of life and is expensive. The disease affects the body’s ability to break down long-chain sugars inside cells. When the sugar chains cannot be broken down and disposed of, they accumulate in the cells and cause progressive damage. This accumulation can happen in the tissues, including the brain. Children affected by the most severe form of the disease rarely live longer than ten years after diagnosis. Severe MPS I occurs in about 1 in 100,000 births. And symptoms appear within a child’s first year of life. In what is referred to as attenuated MPS I, symptoms appear later in childhood. It occurs in about 1 in 500,000 births. Patients with the illness are currently treated with weekly infusions of the missing enzyme. But it’s not enough to cure the disease outright. Immusoft says it can engineer B cells to produce the enzyme instead. “There is a clear need for additional therapies for MPS I, as current interventions are not curative and significant disease related morbidity still exists,” said Paul Orchard, a professor at University of Minnesota who will be the principal investigator on the study. Immusoft’s ISP-001 ( Immune System Programming 001) will be the first engineered B cell therapy to enter into human clinical trials. The ISP technology permits engineering B cells to create biofactories for in vivo therapeutic protein delivery. The concept is to engineer B cells so that they manufacture other proteins instead of antibodies. In other words, ISP modifies a patient’s B cells and instructs the cells to produce gene-encoded medicines. The B cells that are reprogrammed using ISP become miniature drug factories that are expected to persist for many years. “The ISP platform is a first-in-class technology and a pioneering new approach to treat human disease,” said Robert Sikorski, Chief Medical Officer of Immusoft. “It has been rewarding to collaborate with patients, the FDA, investigators, and the Immusoft organization to achieve this important milestone and to launch the first-in-human clinical study.” In the Immusoft press release, Ainsworth refers to the FDA green light as “a historic moment in the field of cell and gene therapies.”
4 min
September 13, 2022 Pre-Workout Panax Ginseng May Enhance Muscle Performance
Brazilian researchers have studied the effect of Panax Ginseng on muscle force and muscle excitation during an eccentric-based exercise. They also studied the effect on subsequent muscle damage and delayed-onset muscle soreness. Eccentric-based exercise is defined as exercise that includes repeated muscle contractions under load. More and more athletes use dietary supplements derived from herbs such as Panax Ginseng to reduce exercise-induced muscle damage. It has been reported, for example, that Panax Ginseng supplementation for a week decreases markers of muscle damage after uphill running. Panax Ginseng is considered a legal sport supplement, as it is not listed as a prohibited substance by the World Anti-Doping Agency. The study was motivated by the lack of detailed information about the use of Panax Ginseng to attenuate the effects of a resistance exercise with eccentric emphasis. Resistance training with eccentric emphasis is largely used to enhance muscle force and prevent injuries in athletes. An excessive eccentric workload, however, may have a negative consequence on exercise performance. Based on previous preliminary results, the researchers hypothesized that Panax Ginseng would increase muscle excitation and attenuate perceived effort during the eccentric-based exercise. That, in turn, would mitigate the muscle damage, delayed-onset muscle soreness, and force reduction over the recovery period. A paper is published in Journal of Strength and Conditioning Research. The researchers report the methods and results of a study of the effects of Panax Ginseng supplements on young male athletes. The participants in the study, ten young male runners, sprinters, and jumpers, had been training regularly six times per week and had competed at the national level in the year before the study. The main finding of this study was that Panax Ginseng attenuated perceived effort and increased muscle excitation during a dynamic exercise with eccentric emphasis. The study did not confirm that Panax Ginseng reduced markers of muscle damage and delayed-onset muscle soreness after the eccentric-based exercise. But the study did confirm that Panax Ginseng accelerated the recovery of muscle force and increased the associated muscle excitation. The researchers conclude that an 8-day protocol of Panax Ginseng might be used to improve muscle excitation and accelerate recovery of neuromuscular function after an eccentric exercise. The researchers are persuaded that the results of this study are applicable to young athletes who practice sports with a high eccentric component, and to athletes who compete several times on the same day and/or over consecutive days. Panax Ginseng supplementation at doses of 100 mg per kilogram of body mass, administered in 3 doses a day for 8 days, may accelerate muscle recovery and improve muscle force. Thrivous develops Surge Acute Nootropic to enhance energy and focus. Each serving provides a clinical dose of Panax Ginseng, along with complementary nutrients. As suggested by this study, Thrivous Surge may enhance muscle force and recovery. Purchase Surge online in the Thrivous store today!
4 min
September 06, 2022 Genetically-Modified Cancer-Killing Oncolytic Viruses
In May, City of Hope and Imugene Limited announced that the first patient was dosed in a phase 1 clinical trial evaluating the safety of a new oncolytic (cancer-killing) virus. It's called CF33-hNIS Vaxinia. And it's used in people with advanced solid tumors. The trial is expected to run for two years. City of Hope is one of the largest cancer research and treatment organizations in the United States. And Imugene Limited is a clinical-stage immuno-oncology company. Oncolytic viruses are designed to both selectively kill cancer cells and activate the immune system against cancer cells. They have the potential to improve clinical response and survival. Oncolytic viruses are based on viruses found in nature. The viruses are genetically modified to infect, replicate in, and kill cancer cells, while sparing healthy cells. Oncolytic virus therapy seems to me to be an elegant and very promising approach to cancer therapy. Once perfected in the lab and validated by clinical trials, it could make a real difference to cancer patients. The oncolytic virus developed by City of Hope has been shown to shrink colon, lung, breast, ovarian, and pancreatic cancer tumors. This has been done in preclinical laboratory and animal models. “Our previous research demonstrated that oncolytic viruses can stimulate the immune system to respond to and kill cancer, as well as stimulate the immune system to be more responsive to other immunotherapies, including checkpoint inhibitors,” said principal investigator Daneng Li. “Now is the time to further enhance the power of immunotherapy, and we believe CF33-hNIS has the potential to improve outcomes for our patients in their battle with cancer.” CF33 is a combination of genomic sequences from multiple vaccinia virus strains to generate a new, safer, and more potent virus. The vaccinia virus spreads rapidly from cell to cell and is highly toxic for many types of cancer cells. When combined with an extra gene called hNIS, CF33 is called Vaxinia. hNIS enables imaging to track the virus in vivo and mediate targeted radiotherapy. CF33 with hNIS, along with other genes that enable enhancement of anti-cancer immunotherapy, is called CHECKVacc. “Interestingly, the same characteristics that eventually make cancer cells resistant to chemotherapy or radiation treatment actually enhance the success of oncolytic viruses, such as CF33-hNIS,” said Yuman Fong. Fong played a key role in developing the genetically modified virus. He continued, “We are hoping to harness the promise of virology and immunotherapy for the treatment of a wide variety of deadly cancers.” Last month, Imugene announced that City of Hope had dosed the first patient in cohort 3 in the phase I clinical trial of the CHECKvacc variant. The trial is recruiting patients with triple negative metastatic breast cancer that has spread to other places in the body. “We are pleased with the continued progress being made in this trial,” said Imugene CEO Leslie Chong. CHECKvacc has the potential to improve clinical response and survival in this indication where there are currently no meaningful treatments, and we are eager to deliver on that.”
4 min

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