If we were to stop at a first glance, the use of liquid biopsy would be limited in the clinical practice of colorectal cancer to cases where tumour tissue is unavailable or insufficient. In reality, we are at the beginning of a pathway where the true potential of liquid biopsy is developing rapidly in several directions. This is confirmed by the research results of Prof. Andrea Sartore Bianchi - Director of the Division of Clinical Research and Innovation in Medical Oncology at the Grande Ospedale Metropolitano Niguarda in Milan. One of the most promising applications of liquid biopsy is the detection of minimal residual disease, a potentially game-changing application for oncologists in the field of colorectal cancer, that guides the choice of the most appropriate treatment for patients.

Find out how liquid biopsy is absolutely the new goal of precision oncology, capable of technologically and culturally revolutionising clinical practice, in this TJ Talks podcast, hosted by Prof. Giancarlo Pruneri.

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The field of bioinformatics is rapidly evolving, shaping the future of biomedical research and precision medicine. From cutting-edge advancements in computational biology to AI-driven solutions, what will the landscape look like in Italy in the coming years, and what opportunities will emerge for young bioinformaticians?In this TJ Talks event, the Bioinformatics Section Editor of Tumori Journal, Prof. Lorenzo Ferrando - Research Associate of Applied Medical Technology and Sciences, Department of Internal Medicine, University of Genoa - guides us through a discussion on the key trends and career prospects in bioinformatics. Joining him is Prof. Matteo Benelli, Associate Professor of Biochemistry at the University of Florence and Co-Principal Investigator of AURORA, an international research program dedicated to uncovering the molecular mechanisms driving therapy response and resistance in recurrent metastatic breast cancer.

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Drug resistance is a major challenge in oncology and genetically-engineered mouse models represent powerful tools to identify new approaches for its overcoming.

In this TJ Talks podcast, Prof Paola Perego, Pharmacology Section Editor of Tumori Journal and Adjunct Professor at the University of Insubria, talks with Professor Sven Rottenberg, head of the Institute of Animal Pathology at the University of Bern, about drug resistance and the reasons why it is so difficult to eradicate tumors during treatment.

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Dr. Arsela Prelaj is confident: the implementation of Artificial Intelligence in Oncology, in the near future, will be aimed at advances in screening and the use of images, such as radiomics; in digital pathology, for a diagnostic task, and in applying Large Language Model for automation tasks. However, there will be climbs to overcome along the way.

In this TJ Talks podcast, Dr Arsela Prelaj, Thoracic Oncologist and Director of the Artificial Intelligence for Oncology Lab at the National Cancer Institute of Milan, talks with Prof. Giancarlo Pruneri about a new world where physicians will interact with Artificial Intelligence in daily clinical practice.

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In this TJ Talks podcast, Dr Luca Agnelli, Tumori Journal Section Editor for Bioinformatics, meets Prof George Calin, a distinguished scientist with an extraordinary career dedicated to studying microRNAs, non-coding RNAs, and their impact on cancer.

Listening to their exciting conversation, you will be engaged in the Prof. Calin's diverse research experiences across Eastern Europe, Western Europe, and the USA, while knowing into key topics in scientific research. These include challenges to amend the peer-review process and the pressing question of whether to focus on generating more big data or optimizing the use of existing -omics datasets. 

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A scientific society for integrating all aspects of cancer care - diagnostics, pathology, surgery, radiation, and medical oncology -through a multidisciplinary approach, because the future of medical oncology will focus on understanding cancer biology and intercepting the disease before it appears or recurs.
In this TJ Talks, prof. Giuseppe Curigliano, chair of the Division of Early Drug Development at the European Institute of Oncology in Milan, and professor at the University of Milan School of Medicine, talks with prof. Giancarlo Pruneri on the future of precision oncology and his commitment as President-elect of ESMO.

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Evidence suggests that dietary interventions can effectively delay, treat and even prevent certain illnesses. This leads to the hypothesis that metabolic interventions might aid cancer treatment, and this is the focus of the conversation with one of the most distinguished researchers in the field.

The guest of this episode of TJ Talks, hosted by prof. Giancarlo Pruneri, is dr. Claudio Vernieri, breast oncologist at the National Cancer Institute of Milan, and PI of the Breakfast-2 study. Breakfast-2 is a very promising prospective study on the efficacy of a metabolic intervention combined to chemo-immunotherapy for patients with triple negative breast cancer.

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The role of pathologists in precision oncology is increasingly recognised as central to effective cancer diagnosis and treatment. Their expertise in tumor classification and biomarker identification is crucial for the development of personalised therapies through advanced molecular biology techniques.

To explore the unique aspects of the pathology postgraduate course at University of Milan, the Editor in Chief of Tumori Journal, Prof. Giancarlo Pruneri, invited Dr. Emanuele Frigo, who is completing his PhD in Milan, and through his experiences and insights, we will discover the distinctive opportunities offered by INT's PhD programme and how it shapes the future of pathologists and physician-scientists.

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TJ Talks is an educational initiative featuring conversations about oncology led by Prof. Giancarlo Pruneri, Editor in Chief of Tumori Journal.

The podcast series aims to explore a variety of topics of interest that reflect the dynamic and evolving nature of oncology research, with contributions from renowned international experts and promising young researchers in the field. Through these insightful discussions, TJ Talks seeks to support the professional development of clinicians and researchers working to improve the cancer care.

TJ Talks is available on our website and on the best podcast platforms.

Follow us on Twitter and LinkedIn to always be updated on cancer research and clinical practice in oncology!

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