Drs Harrington and Gibson provide their annual roundup of what they consider the key cardiovascular trials of 2021. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit

This podcast is intended for US healthcare professionals only.

To read a full transcript of this episode or to comment please visit:

https://www.medscape.com/viewarticle/963475

https://www.medscape.com/author/bob-harrington

Antiplatelet Therapy

Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease

https://doi.org/10.1056/NEJMoa2102137

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk

https://doi.org/10.1056/NEJMoa2108749

Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI

https://doi.org/10.1001/jama.2019.8145

Aspirin Versus Clopidogrel for Chronic Maintenance Monotherapy After Percutaneous Coronary Intervention (HOST-EXAM): An Investigator-Initiated, Prospective, Randomised, Open-Label, Multicentre Trial

https://doi.org/10.1016/S0140-6736(21)01063-1

SGLT2 Inhibitors and GLP-1 Agonists

Empagliflozin in Heart Failure with a Preserved Ejection Fraction

https://www.nejm.org/doi/full/10.1056/NEJMoa2107038

Once-Weekly Semaglutide in Adults with Overweight or Obesity

https://www.nejm.org/doi/full/10.1056/NEJMoa2032183

Cardiac Surgery and PCI

Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke

https://doi.org/10.1056/NEJMoa2101897

Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation

https://doi.org/10.1056/NEJMoa2115961

Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery

https://doi.org/10.1056/NEJMoa2112299

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