ACCEL Lite: Featured ACCEL Interviews on Exciting CV Research

The PRESC1SE-MI trial evaluated whether an accelerated diagnostic pathway for suspected myocardial infarction could improve Emergency Department efficiency without compromising safety. Compared with standard care, the accelerated strategy demonstrated similar safety but did not reduce Emergency Department length of stay.

In this episode, Jeroen J. Bax PhD, MD, FACC and Jasper Boeddinghaus, MD discuss "PRESC1SE-MI: Safety and efficacy of the ESC 0/1-hour Pathway".

As TAVI expands to younger and healthier patients, valve durability has become an increasingly important consideration. However, the optimal antithrombotic strategy to support long-term valve function remains unclear. This trial compared antiplatelet monotherapy with NOAC monotherapy to help address this unmet need.

In this episode, Deepak L. Bhatt MD, MPH, MBA, FACC and Øyvind H. Lie, MD, PhD, MSc examine the results of "ACASA-TAVI: Antithrombotic therapy after TAVI".

Catheter ablation is frequently performed to improve quality of life in patients with atrial fibrillation (AF). This randomized multicenter trial compared catheter ablation with a sham procedure to assess the true effect of the intervention on AF-related quality of life.

In this episode, Clyde W. Yancy, MD, MACC and Rolf Wachter, MD discuss the results of "PVI-SHAM-AF: Pulmonary vein isolation versus SHAM in AF".

The FUND-HF trial found that financial support provided soon after hospitalization is a practical strategy for improving medication adherence among economically vulnerable patients with heart failure and reduced ejection fraction. These results lay the groundwork for future trials designed to examine the durability of these benefits and their effects on health-related quality of life and clinical outcomes.

In this interview, Alison L. Bailey, MD, FACC and Ambarish Pandey, MD, MS examine the effect of financial support on quality of life and medication adherence among low-income patients following hospitalization for heart failure.

The future of cardiovascular health depends on prevention that begins early in life. This episode reviews strategies for recognizing cardiovascular risk at an early stage and implementing interventions that can alter the trajectory of atherosclerotic cardiovascular disease before complications occur.

In this interview, Allen J. Taylor, MD, FACC and Michael J. Blaha MD, MPH discuss Primordial Prevention of Cardiovascular Disease (CVD) in Young.

Cardiovascular protection during cancer treatment is critical to help prevent complications such as heart failure. Patients should be educated on risk factors, symptom awareness, and heart-healthy behaviors. Oncologists should incorporate cardiovascular risk assessment and surveillance into treatment planning, while general cardiologists should understand the potential cardiotoxic effects of cancer therapies and partner closely with oncology teams to support long-term patient health.

In this interview, Dipti Itchhaporia MD, MACC and Ana Barac, MD, PhD, FACC discuss Umbrella: Cardioprotection During Treatment.

Nonobstructive hypertrophic cardiomyopathy (HCM) represents one of the greatest areas of unmet need in HCM management. A key question is identifying the primary driver of symptoms in these patients, as many experience significant functional limitations despite the absence of left ventricular outflow tract obstruction. Understanding the rate and mechanisms of heart failure progression in nonobstructive HCM is also critical, given the substantial morbidity associated with the disease. As a result, there is strong interest in novel therapies that may address underlying disease pathology and improve long-term patient outcomes.

In this interview, Matthew Martinez, MD, FACC and Martin Maron, MD examine treatment for nonobstructive HCM.

The VESALIUS-CV trial demonstrated that the PCSK9 inhibitor evolocumab significantly reduced the risk of a first major cardiovascular event in patients with diabetes who had no known significant atherosclerosis. These findings challenge current clinical practice, where PCSK9 inhibitors are typically reserved for secondary prevention in patients with prior heart attack or stroke. Importantly, the results support earlier, more proactive lipid-lowering intervention, showing benefit even before overt atherosclerotic disease is evident. This paradigm shift underscores the opportunity to intensify preventive strategies and reduce cardiovascular risk earlier in high-risk populations.

In this interview, Nanette Kass Wenger MD, MACC and Nicholas Marston, MD discuss the VESALIUS-CV Trial.

Randomized trials in stable ischemic heart disease (SIHD) show revascularization does not reduce death or myocardial infarction versus guideline-directed medical therapy, with benefit limited to symptom relief. This likely reflects lesion–ischemia mismatch, unclear ischemia origin, effective modern medical therapy, and trial design constraints. As a result, a prognostic advantage is difficult to demonstrate in broad SIHD populations. Exceptions where revascularization may improve outcomes include severe left main disease, significant left ventricle dysfunction, large ischemic burden, and refractory angina.

In this interview, Allen J. Taylor MD, FACC and Sanjay Kaul, MBBS examine 'Why Can't We Prove Revascularization Is Better Than Medical Therapy for SIHD?'

ecent advancements in echocardiography since ACC.25 highlight a shift toward greater precision, efficiency, and consistency in cardiac imaging. Standardized echo reporting is now recognized as a key marker of quality care, improving communication and supporting more reliable clinical decisions, while artificial intelligence enhances imaging through automated measurements and diagnostic support. Together, these innovations strengthen echocardiography's foundational role in heart disease management by improving accuracy, consistency, and overall patient outcomes.

In this interview, Steven E. Nissen MD, MACC David H. Wiener, MD, FACC discuss practice-changing advancements in echocardiography.