In this inaugural episode of the new podcast series produced by ACC’s Interventional Member Section, Dr. Poonam Velagapudi is joined by featured guests Drs. Debabrata Dash and Thomas Cuisset to discuss the Highlights from EuroPCR 2025.  

 Explore key insights from the 4D-ACS trial, followed by a discussion on its practical impact in clinical settings. The discussants examine the FAITAVI trial, highlighting major findings and their influence on procedural decision-making. A recent meta-analysis is also reviewed, with commentary on how the collective evidence may shape real-world interventional strategies. Tune in for a dynamic exchange on cutting-edge trials and their implications for the cath lab. 

 Related References:     

1. The FAITAVI trial: angiography versus physiology-guided PCI in patients undergoing TAVI – 12-month follow-up data (PCR Online). 2025. Available at: https://www.pcronline.com/News/PCR-Press-Releases/2025/EuroPCR-2025-The-FAITAVI-trial-angiography-versus-physiology-guided-PCI-in-patients-undergoing-TAVI-12-month-follow-up-data. Accessed 6/24/25. 

1. Ribichini F, Pesarini G, Fabris T, et al. A randomised multicentre study of angiography- versus physiologyguided percutaneous coronary intervention in patients with coronary artery disease undergoing TAVI: design and rationale of the FAITAVI trial. EuroIntervention. 2024 Apr 15;20(8):e504-e510. doi: 10.4244/EIJ-D-23-00679.  

1. Jang Y, Park SD, Lee JP, et al. One-month dual antiplatelet therapy followed by prasugrel monotherapy at a reduced dose: the 4D-ACS randomised trial. EuroIntervention. 2025 May 21:EIJ-D-25-00331. doi: 10.4244/EIJ-D-25-00331.  

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In this episode of CardiaCast, Drs. Erin Michos and Joseph Saseen discuss the underuse of lipid-lowering therapies in patients with cardiovascular risk, despite strong evidence and updated guidelines. They highlight the role of bempedoic acid as a non-statin option, especially for statin-intolerant patients. The conversation emphasizes team-based care, shared decision-making, and strategies to navigate insurance barriers to improve LDL-C management. 

 This podcast is part of Bempedoic Acid: New Evidence Transforming the LDL-C Treatment Landscape grant initiative. 

 Educational grant support is provided by Esperion. 

  Related References 

1. Nelson A, Haynes K, Shambhu S, et al. High-intensity statin use among patients with atherosclerosis in the U.S. J Am Coll Cardiol. 2022;79(18):1802–1813. doi:10.1016/j.jacc.2022.02.048 

1. Cannon CP, de Lemos JA, Rosenson RS, et al. Use of lipid-lowering therapies over 2 years in GOULD, a registry of patients with atherosclerotic cardiovascular disease in the US. JAMA Cardiol. 2021;6(9):1060–1068. doi:10.1001/jamacardio.2021.1810 

1. Worledge EA, Billups SJ, Titus OJ, Saseen JJ. Achievement of low-density lipoprotein cholesterol thresholds in very high-risk atherosclerotic cardiovascular disease. J Clin Lipidol. Published online April 11, 2025. doi:10.1016/j.jacl.2025.04.186 

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In this episode Drs. Poonam Velagapudi, Saraschandra Vallabhajosyula, and James Hermiller explore the critical topic of occupational safety in the cath lab. While healthcare providers focus on treating patients, their work environment can put their own health at risk—particularly long-term impact of wearing heavy lead protection. Drawing from discussions at the Society for Cardiovascular Angiography & Interventions (SCAI) 2025 Think Tank Sessions, the episode highlights data on lead-free and reduced-lead solutions aimed at preventing back pain and injury among cardiac catheterization operators. Tune in for a timely conversation on protecting the well-being of the heart team. 

Related References 

1. Strepkos D, Rempakos A, Alexandrou M, et al. How to Improve Radiation Protection in Interventional Cardiology Procedures. Circ Cardiovasc Interv. 2025;18(4):e014808. doi:10.1161/CIRCINTERVENTIONS.124.014808 

1. Women in Innovations (WIN) Radiation Safety (SCAI website). 2025. Available at: https://scai.org/membership/career-development/women-innovations-win/win-radiation-safety . Accessed 06/17/25. 

1. SCAI Highlights Cath Lab Radiation and Orthopaedic Hazards (Cardiovascular News website). Available at: https://cardiovascularnews.com/scai-highlights-cath-lab-radiation-and-orthopaedic-hazards/. Accessed 06/17/25. 

1. Occupational Health Hazards in the Cardiac Catheterization Laboratory (SCAI website). 2025. Available at: https://scai.org/occupational-health-hazards-cardiac-catheterization-laboratory . Accessed 06/17/25. 

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In this episode, Drs. Jenna Skowronski, Francesco Castagna and Saraschandra Vallabhajosyula unpack how assumptions drawn from ST-segment elevation myocardial infarction (STEMI) data may be leading us astray in broader shock management—and what that means for patient outcomes, clinical decision-making, and future research. Why do we keep applying STEMI solutions to non-STEMI problems? Are we oversimplifying cardiogenic shock? And what does the real-world data actually tell us? 

Join us for a candid, fast-paced conversation that challenges dogma, calls for nuance, and might just change the way you approach shock. 

 Related References:  

1.  Møller JE, Engstrøm T, Jensen LO, et al. Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock. N Engl J Med. 2024;390(15):1382-1393. doi:10.1056/NEJMoa2312572. 

1. Kochar A, Vallabhajosyula S, John K, et al. Factors associated with acute limb ischemia in cardiogenic shock and downstream clinical outcomes: Insights from the Cardiogenic Shock Working Group. J Heart Lung Transplant. 2024;43(11):1846-1856. doi:10.1016/j.healun.2024.06.012. 

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n this episode, Drs. Brittany Weber and Michael Garshick discuss “Pharmacologic Interventions to Lower hs-CRP.” This podcast is part of the Inflammation in Cardiovascular Health: Raising Awareness of the Increasing Role of hs-CRP grant initiative.  

 Educational support for this initiative is provided by Novo Nordisk.  

 Click here to learn more. 

 Related References:  

1. Nidorf SM, Fiolet ATL, Mosterd A, et al; LoDoCo2 Trial Investigators. Colchicine in Patients with Chronic Coronary Disease. N Engl J Med. 2020;383(19):1838-1847. 

1. Ridker PM. From CANTOS to CIRT to COLCOT to Clinic: Will All Atherosclerosis Patients Soon Be Treated With Combination Lipid-Lowering and Inflammation-Inhibiting Agents? Circulation. 2020;141(10):787-789. 

1. Ridker PM. From RESCUE to ZEUS: Will interleukin-6 inhibition with ziltivekimab prove effective for cardiovascular event reduction? Cardiovasc Res. 2021;117(11):e138-e140. 

1. Ridker PM, Bhatt DL, Pradhan AD, et al; PROMINENT, REDUCE-IT, and STRENGTH Investigators. Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials. Lancet. 2023;401(10384):1293-1301. 

1. Ridker PM, Moorthy MV, Cook NR, et al. Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women. N Engl J Med. 2024;391(22):2087-2097. 

1. Tardif JC, Kouz S, Waters DD, et al. Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction. N Engl J Med. 2019;381(26):2497-2505. 

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In this episode, Drs. Purvi Parwani and Sharonne Hayes discuss “Cardiovascular Health Throughout a Woman's Lifecycle.” This podcast is part of the Monitoring Blood Pressure Throughout a Woman’s Lifecycle grant initiative. 

Educational support for this initiative is provided by Omron. 

To visit the course page for the Monitoring Blood Pressure Throughout a Woman’s Lifecycle grant, click here. 

 Suggested Materials 

1. El Khoudary SR, Aggarwal B, Beckie TM, et al; American Heart Association Prevention Science Committee of the Council on Epidemiology and Prevention; and Council on Cardiovascular and Stroke Nursing. Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association. Circulation. 2020;142(25):e506-e532. 

1. Lau ES, Michos ED. Blood Pressure Trajectories Through the Menopause Transition: Different Paths, Same Journey. Circ Res. 2022;130(3):323-325. 

1. Samargandy S, Matthews KA, Brooks MM, et al. Trajectories of Blood Pressure in Midlife Women: Does Menopause Matter? Circ Res. 2022;130(3):312-322. 

1. Shimbo D, Artinian NT, Basile JN, et al; American Heart Association and the American Medical Association. Self-Measured Blood Pressure Monitoring at Home: A Joint Policy Statement From the American Heart Association and American Medical Association. Circulation. 2020;142(4):e42-e63. 

1. Wenger NK, Arnold A, Bairey Merz CN, et al. Hypertension Across a Woman’s Life Cycle. J Am Coll Cardiol. 2018 Apr 24;71(16):1797-1813. 

1. Wenger NK, Ferdinand KC, Bairey Merz CN, et al. Women, hypertension, and the systolic blood pressure intervention trial. Am J Med. 2016;129:1030-36. 

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“Heart Vision” is a CardiaCast podcast series stemming from the ACC Cardiovascular Imaging Section Leadership Council. This podcast series will tackle topics on emerging multimodality imaging data, trends, practice patterns, disease status and advocacy effort.

In this episode of Heart Vision, Dr. Purvi Parwani sits down with Dr. Ana Barac, a global leader in cardio-oncology and advanced cardiovascular imaging. Together, they explore the evolving role of imaging in cancer care, the challenges of clinical integration, and how imagers can carve out a meaningful presence in this rapidly growing field. This conversation offers both practical insights and visionary thinking for anyone at the intersection of heart and cancer care.

“Courtside with the Chair” is a series within CardiaCast presented by the Sports and Exercise Cardiology Member Section covering topics within the field of sports and exercise cardiology. In this episode, Dr. Jonathan Kim is joined by Drs. Rachel Lampert, Dermot Phelan, and Keri Schafer to continue the discussion on the recently released 2025 Clinical Considerations for Competitive Sports Participation for Athletes With Cardiovascular Abnormalities: A Scientific Statement From the American Heart Association and American College of Cardiology. 

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In this episode, Drs. Brittany Weber and Paul Ridker discuss “The What, Who, When, and Why of hs-CRP.” This podcast is part of the Inflammation in Cardiovascular Health: Raising Awareness of the Increasing Role of hs-CRP grant initiative. 

Educational support for this initiative is provided by Novo Nordisk. Click here to learn more: https://learn.acc.org/Page/learnHSCRP  

 Related References 

1.  Cognitive impairment and heart failure: systematic review and meta-analysis. J Card Fail 2017;23:464-75).     

1. Arnett DK, Blumenthal RS, Albert MA, et al. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;140(11):e596-e646. 

1. Benjamin EJ, Muntner P, Alonso A, et al. Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. Circulation. 2019;139:e56–e528. 

1. Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. JACC. 2019;73(24):e285-350. 

1. Lloyd-Jones DM, Braun LT, Ndumele CE, et al. Use of Risk Assessment Tools to Guide Decision-Making in the Primary Prevention of Atherosclerotic Cardiovascular Disease: A Special Report From the American Heart Association and American College of Cardiology. JACC. 2019; 73(24):3153–3167. 

1. Ridker PM. From RESCUE to ZEUS: Will interleukin-6 inhibition with ziltivekimab prove effective for cardiovascular event reduction? Cardiovasc Res. 2021;117(11):e138-e140. 

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“Courtside with the Chair” is a series within CardiaCast presented by the Sports and Exercise Cardiology Member Section covering topics within the field of sports and exercise cardiology. In this episode, Dr. Jonathan Kim is joined by Drs. Baggish, Levine, and Martinez to continue their deep dive into the recently released 2025 Clinical Considerations for Competitive Sports Participation for Athletes With Cardiovascular Abnormalities: A Scientific Statement From the American Heart Association and American College of Cardiology. 

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