Dietary Guidelines of America: What Changed, What Didn’t, and Why it Matters

Guest: Dariush Mozaffarian, M.D., Dr.P.H.

Host: Kyla Lara-Breitinger, M.D., M.H.S.

The release of the new Dietary Guidelines for Americans has sparked important conversations across medicine, public health, and clinical practice. In this three-episode Interview with the Experts mini-series, Mayo Clinic preventive cardiologist Dr. Kyla Lara-Breitinger brings clarity to what the guidelines mean for patients and clinicians alike—cutting through headlines, controversy, and confusion with evidence-based insights from national and Mayo Clinic experts. Together, we explore what’s new, what remains unchanged, where debate persists, and how these guidelines translate into real-world cardiometabolic care, with a strong emphasis on practical, patient-centered nutrition advice.

Topics Discussed:

Referenced article:

Mozaffarian D. The 2025-2030 Dietary Guidelines for Americans. JAMA. Published online January 14, 2026. doi:10.1001/jama.2026.0283 The 2025-2030 Dietary Guidelines for Americans | Lifestyle Behaviors | JAMA | JAMA Network 

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

Recorded on: 27-January-2026

Conduction System Pacing

Guest: Nicholas Tan, M.D., M.S.

Host: Anthony Kashou, M.D.

In this episode of the “ECG Making Waves” segment of Mayo Clinic’s cardiovascular podcast series “Interviews with the Experts,” Dr. Nicholas Tan joins us to discuss conduction system pacing. The listener will hear about the basics and rationale of conduction system pacing, as well as clinical scenarios where it should be considered.

Topics Discussed:

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

Recorded 09-December-2025

AI Detection of Cardiac Amyloidosis

Guest: Patricia Pellikka, M.D.

Host: Malcolm Bell, M.D.

Dr. Patricia Pellikka dives into the AI model she helped build. Working with an AI echo company, Ultromics Ltd., her team built an AI echo model to detect cardiac amyloidosis. The model works from an apical 4 chamber videoclip and was approved by the FDA via the breakthrough pathway. They have validated it internationally in a population with 22% prevalence of cardiac amyloidosis and it had a sensitivity of 85%, specificity 93%, PPV 78%, NPV 96%, and AUC 0.93.  The performance of the model was consistent across cardiac amyloid types; among AL, wild type ATTR, and hereditary ATTR, the sensitivity was 84%, 85%, and 86%, respectively.  The performance of the model was also superior to previously validated scores which use clinical and echocardiographic variables for detecting cardiac amyloidosis. The results of the study were published online in the European Heart Journal in July.

Topics Discussed:

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

Clopidogrel Monotherapy in Chronic Coronary Artery Disease

Guest: Keri Zieminski, APRN, C.N.P., D.N.P.

Host: Sharonne Hayes, M.D.

This episode of Mayo Clinic’s “Interviews With the Experts” will give an overview of clopidogrel monotherapy in patients with chronic CAD that are not on anticoagulation. Discussion will include why there has been a shift towards redefining antiplatelet medical therapy for this patient population, brief overview of recent trials, and how to manage a patient on clopidogrel monotherapy that needs to undergo noncardiac surgery.

Topics Discussed:

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

Global Practices in Cardiac Imaging for Cardiac Sarcoidosis

Guest: Tahir Kafil, M.D.

Host: Sharonne Hayes, M.D.

Cardiac imaging is a cornerstone in the diagnostic work-up and management of cardiac sarcoidosis. However, indications and use of advanced cardiac imaging vary from institution to institution, and even between providers at the same institution. We conducted an international Delphi consensus study of 89 global experts in cardiac sarcoidosis to evaluate real-world clinical practices and use of advanced cardiac imaging. We developed consensus for use of advanced cardiac imaging in cardiac sarcoidosis. Areas lacking consensus were noted as priority areas for research.

Topics Discussed:

The research study cited by Dr. Kafil was published on June 2, 2025. Click the following link to view the paper:

https://www.jacc.org/doi/full/10.1016/j.jcmg.2025.02.010

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

Anticoagulation Monotherapy in Patients with Chronic Coronary Artery Disease and Atrial Fibrillation

Guest: Keri Zieminski, APRN, C.N.P., D.N.P.

Host: Sharonne Hayes, M.D.

This episode of Mayo Clinic’s “Interviews With the Experts” will give an overview of anticoagulation monotherapy in patients with chronic CAD and atrial fibrillation. Discussion will include a brief overview of recently published trials that highlight the use of anticoagulation monotherapy in chronic CAD with atrial fibrillation, and how to manage a patient on anticoagulation monotherapy that needs to undergo noncardiac surgery. 

Topics Discussed:

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

Updated Guidelines for Perioperative Cardiovascular Management for Noncardiac Surgery

Guest: Michael Cullen, M.D.

Host: Kyle Klarich, M.D.

This episode of Mayo Clinic’s “Interviews With the Experts” reviews the assessment of patients with known or suspected cardiovascular disease undergoing noncardiac surgery.  Dr. Michael Cullen discusses recommendations from 2024 ACC/AHA perioperative guidelines regarding medication management before and after noncardiac surgery, including recommendations for antiplatelet therapy and bridging anticoagulation.  Finally, he highlights new recommendations in the recent 2024 ACC/AHA perioperative guidelines and compare these guidelines to the 2022 European Society of Cardiology perioperative guidelines.

Topics Discussed:

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

Obesity, Hypertension, and Risk Factors in Terms of Prevention and Decreasing the Risk of HfpEF

Guest: Affan Irfan, M.D., Ph.D.

Host: Stephen L. Kopecky, M.D.

HFpEF is a type of heart failure where the heart pumps normally but becomes stiff. This leads to fatigue, shortness of breath, and fluid retention. It is closely linked to obesity, hypertension, and metabolic disorders, with cases rising as these conditions become more common.

Topics Discussed:

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

Aortic Regurgitation: Beyond the Valve

Guest: Vidhu Anand, M.B.B.S.

Host: Kyle Klarich, M.D.

In this episode of Mayo Clinic’s “Interviews With the Experts,” Dr. Klarich and Dr. Anand discuss evolving approaches to assessing left ventricular remodeling in chronic aortic regurgitation. Dr. Vidhu Anand discusses research showing that LV volumes, global longitudinal strain, and myocardial fibrosis can detect dysfunction earlier than traditional guideline thresholds. Listeners can expect to better understand the role of multimodality imaging, extra valvular involvement, and practical steps echocardiographers can take to optimize AR assessment. 

Topics Discussed:

Please reference Dr. Anand's research article(s) here:

https://pubmed.ncbi.nlm.nih.gov/39545891/

https://pubmed.ncbi.nlm.nih.gov/33253815/

https://pubmed.ncbi.nlm.nih.gov/39218370/

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

Presentation, Evaluation, and Management of Premature Ventricular Contractions

Guest: Alan M. Sugrue, M.B., B.Ch., B.A.O.

Host: Anthony H. Kashou, M.D.

In this episode, Dr. Anthony Kashou and Dr. Alan Sugrue cover a practical, evidence-based approach to premature ventricular contractions (PVCs), from incidental findings to high-burden, high-risk presentations. Listeners will gain tools to differentiate benign from pathologic PVCs, understand when to monitor versus refer, and recognize the role of catheter ablation in improving outcomes.

Topics Discussed:

LinkedIn: Mayo Clinic Cardiovascular Services

Podcast episode transcript found here.