Evolving Treatment Landscape in Transthyretin Cardiac Amyloidosis

Guest: Rosalyn Adigun, M.D., Pharm.D.

Host: S. Allen Luis, M.B.B.S., Ph.D.

In this episode of Mayo Clinic’s “Interviews With the Experts,” Dr. Allen Luis interviews Dr. Rosalyn Adigun on transthyretin cardiac amyloidosis. Listeners will come away with a detailed overview of the evolution of treatment options for patient diagnosed with transthyretin amyloid cardiomyopathy, highlighting historical perspectives, early registration studies, current treatment options, and an outlook on future directions in the management of transthyretin cardiac amyloidosis.

Topics Discussed:

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

Radiation Therapy and its Effect on the Heart and Cardiac Devices

Guest: Nicholas Tan, M.D., M.S.

Host: Anthony H. Kashou, M.D.

Mayo Clinic electrophysiologist Dr. Nicholas Tan joins Dr. Anthony Kashou on this episode of “ECG Making Waves” to discuss how radiation therapy can impact the heart and heart rhythm. After listening to this podcast, listeners will have developed awareness of the complexities behind managing cardiac devices in cancer patients.

Topics Discussed:

LinkedIn: Mayo Clinic Cardiovascular Services

Podcast episode transcript found here.

When to Consider Intervention for Peripheral Arterial Disease

Guest: Stan Henkin, M.D.

Host: Malcolm Bell, M.D.

Although optimal medical therapy is key to decrease the risk of major adverse cardiac events in patients with peripheral artery disease (PAD), lower extremity arterial revascularization also plays an important role in management of symptoms and prevention of amputation. Thus, it is important to recognize the optimal timing for patient to be referred for lower extremity arterial revascularization. This podcast will discuss when patients with established PAD should be considered for peripheral revascularization.

Topics Discussed:

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

Heart Healthy Diet: How to Evaluate Your Patients

Guest: Kyla Lara-Breitinger, M.D.

Host: Stephen L. Kopecky, M.D.

Nutrition counseling plays a vital role in cardiovascular care, and even brief conversations can make a meaningful impact. Rapid dietary screeners offer a practical way to assess how heart healthy a patient’s eating pattern is, helping providers initiate valuable discussions. While no single cardioprotective diet stands above the rest, emphasizing reduced intake of ultra-processed foods and ensuring adequate protein—primarily from plant-based sources and lean animal proteins like poultry, fish, and seafood—can support heart health. These dietary priorities become especially important in later life stages, when maintaining lean muscle mass is critical to reducing risks of frailty, morbidity, and mortality.

Easily check your diet with mini-eat.org as discussed by Dr. Lara-Breitinger and Dr. Kopecky! 

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

2024 Peripheral Arterial Guidelines: What’s New

Guest: Stan Henkin, M.D.

Host: Malcolm Bell, M.D.

The new iteration of ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease came out in 2024, providing multiple new recommendations for the management of lower extremity peripheral artery disease (PAD) as compared to the 2016 PAD Guideline. These recommendations were made in light of multiple new trials since the prior guideline, including use of antiplatelet and antithrombotic therapy, lipid-lowering therapy and structured exercise therapy. For the first time, these guidelines also underscore the importance of health disparities in PAD. This podcast will highlight these new recommendations with focus on prevention of adverse events in patients with PAD. 

Topics Discussed:

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

Patients Struggling With SVT/AVNRT and Catheter Ablation

Guest: Christopher DeSimone, M.D., Ph.D.

Host: Anthony H. Kashou, M.D.

In this episode, Dr. Anthony Kashou and Dr. Christopher DeSimone dive into the challenges patients face with supraventricular tachycardia (SVT) and atrioventricular nodal reentrant tachycardia (AVNRT). They explore treatment options ranging from medications to catheter ablation, highlighting how these approaches aim to improve quality of life. Listeners will learn what to expect during an ablation procedure, including safety, anesthesia, and risks. Most importantly, they discuss how patients can feel empowered to make informed decisions about their care and reclaim confidence in their health. 

Topics Discussed:

LinkedIn: Mayo Clinic Cardiovascular Services

Podcast episode transcript found here.

Effects of Social Isolation and Loneliness on the Heart

Guest: Amir Lerman, M.D.

Host: Stephen L. Kopecky, M.D.

Social isolation and loneliness are common, mainly in the elderly, and are regarded as major cardiovascular risk factors. The factors are associated with an increase in cardiovascular events and mortality. Additionally, social isolation and loneliness are associated with increased systemic inflammation and progression of atherosclerosis

Topics Discussed:

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

Ischemia with No Obstructive Arteries (INOCA) in 2024 

Guest: Claire Raphael, M.B.B.S., Ph.D.

Host: Sharonne Hayes, M.D.

INOCA is a common condition. It is an acronym that stands for ischemia with non-obstructive coronary artery disease. We discuss when to consider a diagnosis of INOCA, how to diagnose it and how to treat patients.

Topics Discussed:

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

Statin Myopathy

Guest: Stephen Kopecky, M.D.

Host: Sharonne Hayes, M.D.

Statins are very helpful to lower LDL cholesterol and subsequently lower cardiovascular risk.  Studies of statins have excluded subjects that are statin intolerant which is usually due to muscle symptoms such as aches, called myalgias, muscle cramps, or weakness.  One of the most significant predictors of statin intolerance is the dose -the higher the dose, the more likely to develop intolerance.  Accepted in recommended ways to minimize intolerance is to use generic combination therapy with a lower dose statin and a cholesterol absorption inhibiting agent such as ezetimibe.  Newer agents such as PCS K 9 inhibitors and inclisiran, both given subQ, and bempedoic acid may reduce statin muscle symptoms.

Topics Discussed:

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

No CME credit offered for this episode.

Podcast episode transcript found here.

Recent Updates in AF Guidelines

Guest: Christopher DeSimone, M.D., Ph.D.

Guest: Abhishek Deshmukh, M.B.B.S.

Host: Anthony H. Kashou, M.D.

There have been several recent publications from major societies (ACC/HRS/EHRA/ESC) regarding atrial fibrillation management updates.  These include updates to treatment interventions in patients with AFib such as catheter ablation, medical therapy, heart failure, and timing of intervention.

Topics Discussed:

LinkedIn: Mayo Clinic Cardiovascular Services

Podcast episode transcript found here.