Drs Harrington, Rodriguez, and Ridker discuss the changing field of cardiac prevention, where imaging fits in, and the new concept of standard modifiable risk factor-less patients.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit

https://www.medscape.com/author/bob-harrington

Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association

https://doi.org/10.1161/CIR.0000000000001078

Development and Validation of the American Heart Association's PREVENT Equations

https://doi.org/10.1161/CIRCULATIONAHA.123.067626

C-Reactive Protein and Cardiovascular Risk Among Women With No Standard Modifiable Risk Factors: Evaluating the 'Smurf-Less but Inflamed'

https://doi.org/10.1093/eurheartj/ehaf658

Mortality in STEMI Patients Without Standard Modifiable Risk Factors: A Sex-Disaggregated Analysis of SWEDEHEART Registry Data

https://doi.org/10.1016/S0140-6736(21)00272-5

Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women

https://www.nejm.org/doi/10.1056/NEJMoa2405182

Statins for the 'SMuRFLess But Inflamed': Silent Vascular Inflammation and the Challenge of Translational Science

https://doi.org/10.1016/j.jacbts.2025.101318

VERVE-101: A Promising CRISPR-Based Gene Editing Therapy That Reduces LDL-C and PCSK9 Levels in HeFH Patients

https://academic.oup.com/ehjcvp/article/10/2/89/7492807

You may also like:

Hear John Mandrola, MD, give a summary and his perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact [email protected]

Cardiologist and author Eric Topol discusses the science of longevity, why the key to healthy aging is prevention, and the perils of a fixation on reversing ageing.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

Super Agers: An Evidence-Based Approach to Longevity

https://www.simonandschuster.com/books/Super-Agers/Eric-Topol/9781668067666

Wellderly study

https://www.scripps.edu/science-and-medicine/translational-institute/translational-research/genomic-medicine/wellderly/

Lotte Bjerre Knudsen

https://erictopol.substack.com/p/lotte-bjerre-knudsen-the-scientist

Organ aging signatures in the plasma proteome track health and disease

https://doi.org/10.1038/s41586-023-

Deep Medicine

https://drerictopol.com/portfolio/deep-medicine/

You may also like:

Hear John Mandrola, MD, give a summary and his perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact [email protected]

The 2021 winner of the Nobel Prize in medicine, Ardem Patapoutian speaks of his love for science, why he wishes he had an MD, and the importance of getting out of the lab to inspire young people.

This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit:

https://www.medscape.com/author/bob-harrington

Nobel Prize in Physiology or Medicine 2021

https://pubmed.ncbi.nlm.nih.gov/39429349/

https://www.nobelprize.org/prizes/medicine/2021/press-release/

Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels https://pubmed.ncbi.nlm.nih.gov/20813920/

PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex

https://doi.org/10.1126/science.aau6324

PIEZO Ion Channels in Cardiovascular Functions and Diseases

https://doi.org/10.1161/CIRCRESAHA.123.322798

You may also like:

Hear John Mandrola, MD, with his summary and perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact

[email protected]

Bob Harrington chairs a panel with two early-career physician researchers and the head of a large research institute on what the future holds in lights of NIH funding cuts.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

You may also like:

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic

Questions or feedback, please contact [email protected]

The rejection by the ABMS of a certification board run by cardiologists prompted this discussion on how medical training should change and the best methods to assess clinical competency.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit

https://www.medscape.com/author/bob-harrington

New Cardiology Board Denied but 'Not Done With This Fight' https://www.medscape.com/viewarticle/new-cardiology-board-denied-not-done-this-fight-2025a10006j8

You may also like:

Hear Dr John Mandrola's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic

Questions or feedback, please contact [email protected]

A panel discussion of a Presidential Advisory from the American Heart Association that outlines the importance of funding for scientific research and the need for a robust National Institutes of Health.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit

https://www.medscape.com/author/bob-harrington

INCLUDE URLS and full titles for some of the pertinent studies cited.

You may also like:

Principles for the Future of Biomedical Research in the United States and Optimizing the National Institutes of Health: A Presidential Advisory From the American Heart Association

https://doi.org/10.1161/cir.0000000000001319

The Role of Public-Sector Research in the Discovery of Drugs and Vaccines."

https://www.nejm.org/doi/full/10.1056/NEJMsa1008268

Comparison of Research Spending on New Drug Approvals by the National Institutes of Health vs the Pharmaceutical Industry, 2010-2019

https://pubmed.ncbi.nlm.nih.gov/37115539/

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact [email protected]

Drs Harrington and Gibson review their picks for the top cardiology trials of 2024 and look ahead to 2025, particularly what health topics may be prioritized by the new administration.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment https://www.medscape.com/author/bob-harrington

Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction (REDUCE AMI) https://www.nejm.org/doi/abs/10.1056/NEJMoa2401479

Intensive Blood-Pressure Control in Patients with Type 2 Diabetes (BPROAD) https://doi.org/10.1056/nejmoa2412006

Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis EARLY TAVR https://www.nejm.org/doi/full/10.1056/NEJMoa2405880

Asundexian versus Apixaban in Patients with Atrial Fibrillation (OCEANIC-AF) https://doi.org/10.1056/NEJMoa2407105

In the Wake of OCEANIC-AF, Is Equipoise Regarding Factor XI Inhibition Still Afloat? https://www.jacc.org/doi/10.1016/j.jacc.2024.10.105

Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT): a multicentre, open-label, randomised controlled trial https://doi.org/10.1016/S0140-6736(24)00413-6

Preventive Coronary Stents: Not There Yet

https://www.medscape.com/viewarticle/preventive-coronary-stents-not-there-yet-2024a10006yr

Speech by Commissioner Robert M. Califf to the House of Medicine June 16, 2023

https://www.fda.gov/news-events/speeches-fda-officials/speech-commissioner-robert-m-califf-house-medicine-06162023

Evolution of Single-Lead ECG for STEMI Detection Using a Deep Learning Approach

https://doi.org/10.1016/j.ijcard.2021.11.039

From ST-Segment Elevation MI to Occlusion MI: The New Paradigm Shift in Acute Myocardial Infarction https://doi.org/10.1016/j.jacadv.2024.101314

You may also like:

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact [email protected]

A review paper prompted a discussion among cardiologists Bob Harrington, Manesh Patel, and Michael Gibson on whether the ST-segment elevation myocardial infarction paradigm needs an update.

This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

From ST-Segment Elevation MI to Occlusion MI: The New Paradigm Shift in Acute Myocardial Infarction https://doi.org/10.1016/j.jacadv.2024.101314

Angiographic and Clinical Outcomes Among Patients With Acute Coronary Syndromes Presenting With Isolated Anterior ST-Segment Depression: A TRITON-TIMI 38 Substudy https://doi.org/10.1016/j.jcin.2010.05.012

Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021 https://jamanetwork.com/journals/jama/fullarticle/2798440

Evolution of Single-Lead ECG for STEMI Detection Using a Deep Learning Approach https://doi.org/10.1016/j.ijcard.2021.11.039

Implantable Cardiac Alert System for Early Recognition of ST-Segment Elevation Myocardial Infarction https://doi.org/10.1016/j.jacc.2019.01.014

TIME Trial: Effect of Timing of Stem Cell Delivery Following ST-Elevation Myocardial Infarction on the Recovery of Global and Regional Left Ventricular Function: Final 2-Year Analysis https://doi.org/10.1161/CIRCRESAHA.117.311466

Early Versus Delayed Invasive Intervention in Acute Coronary Syndromes https://www.nejm.org/doi/full/10.1056/NEJMoa0807986

Translating AI for the Clinician https://doi.org/10.1001/jama.2024.21772

A Novel Breakthrough in Wrist-Worn Transdermal Troponin-I-Sensor Assessment for Acute Myocardial Infarction https://doi.org/10.1093/ehjdh/ztad015

A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI (CELEBRATE) https://clinicaltrials.gov/study/NCT04825743

Selatogrel Outcome Study in Suspected Acute Myocardial Infarction (SOS-AMI) https://clinicaltrials.gov/study/NCT04957719

You may also like:

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic

Questions or feedback, please contact [email protected]

A review paper prompted a discussion among cardiologists Bob Harrington, Manesh Patel, and Michael Gibson on whether the ST-segment elevation myocardial infarction paradigm needs an update.

This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

From ST-Segment Elevation MI to Occlusion MI: The New Paradigm Shift in Acute Myocardial Infarction https://doi.org/10.1016/j.jacadv.2024.101314

Angiographic and Clinical Outcomes Among Patients With Acute Coronary Syndromes Presenting With Isolated Anterior ST-Segment Depression: A TRITON-TIMI 38 Substudy https://doi.org/10.1016/j.jcin.2010.05.012

Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021 https://jamanetwork.com/journals/jama/fullarticle/2798440

Evolution of Single-Lead ECG for STEMI Detection Using a Deep Learning Approach https://doi.org/10.1016/j.ijcard.2021.11.039

Implantable Cardiac Alert System for Early Recognition of ST-Segment Elevation Myocardial Infarction https://doi.org/10.1016/j.jacc.2019.01.014

TIME Trial: Effect of Timing of Stem Cell Delivery Following ST-Elevation Myocardial Infarction on the Recovery of Global and Regional Left Ventricular Function: Final 2-Year Analysis https://doi.org/10.1161/CIRCRESAHA.117.311466

Early Versus Delayed Invasive Intervention in Acute Coronary Syndromes https://www.nejm.org/doi/full/10.1056/NEJMoa0807986

Translating AI for the Clinician https://doi.org/10.1001/jama.2024.21772

A Novel Breakthrough in Wrist-Worn Transdermal Troponin-I-Sensor Assessment for Acute Myocardial Infarction https://doi.org/10.1093/ehjdh/ztad015

A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI (CELEBRATE) https://clinicaltrials.gov/study/NCT04825743

Selatogrel Outcome Study in Suspected Acute Myocardial Infarction (SOS-AMI) https://clinicaltrials.gov/study/NCT04957719

You may also like:

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic

Questions or feedback, please contact [email protected]

Cardiologists Bob Harrington and Dhruv Kazi discuss the projected burden of cardiovascular disease in 2050, why it's not sustainable, and what can be done to prevent it.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington

INCLUDE URLS and full titles for some of the pertinent studies cited.

Forecasting the Burden of Cardiovascular Disease and Stroke in the United States Through 2050

https://doi.org/10.1161/CIR.0000000000001256

Forecasting the Economic Burden of Cardiovascular Disease and Stroke in the United States Through 2050

https://doi.org/10.1161/CIR.0000000000001258

Calculating the 30-day Survival Rate in Acute Myocardial Infarction: Should we Use the Treatment Chain or the Hospital Catchment Model?

https://doi.org/10.5301/heartint.5000238

Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health

https://doi.org/10.1161/CIR.0000000000001078

Current Trends in Hypertension Identification and Management: Insights from the National Health and Nutrition Examination Survey

https://doi.org/10.1161/JAHA.123.034322

Youth-Onset Type 2 Diabetes: The Epidemiology of an Awakening Epidemic

https://doi.org/10.2337/dci22-0046

US Trends in Cholesterol Screening, Lipid Levels, and Lipid‐Lowering Medication Use in US Adults, 1999 to 2018

https://doi.org/10.1161/JAHA.122.028205

GLP-1 Receptor Agonist Discontinuation Among Patients With Obesity and/or Type 2 Diabetes

https://pubmed.ncbi.nlm.nih.gov/38787563

Health Care by Food

https://healthcarexfood.org/

You may also like:

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact

[email protected]