Trials on lowering salt consumption and treating hypertension in the community impressed Drs Harrington and Gibson in this discussion of the best public health research of 2021.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit:

https://www.medscape.com/author/bob-harrington

CV Public Health Trials

Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS) https://doi.org/10.1016/j.ahj.2019.12.020

A Cluster Randomized Trial of a Village Doctor-Led Intervention on Blood Pressure Control: China Rural Hypertension Control Project

https://www.abstractsonline.com/pp8/?_ga=2.141042993.2042594723.1635046736-1021258137.1633710264#!/9349/presentation/18155

A Remotely Delivered Hypertension and Lipid Program in 10,000 Patients Across a Diverse Health Care Network

https://www.abstractsonline.com/pp8/?_ga=2.141042993.2042594723.1635046736-1021258137.1633710264#!/9349/presentation/18153

COVID-19 Public Health Trials

Impact of community masking on COVID-19: A cluster-randomized trial in Bangladesh

https://www.poverty-action.org/publication/impact-community-masking-covid-19-cluster-randomized-trial-bangladesh

Dexamethasone in Hospitalized Patients with Covid-19

https://doi.org/10.1056/NEJMoa2021436

Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19

https://jamanetwork.com/journals/jama/fullarticle/2775280

The Recovery Trial Initiative

https://www.recoverytrial.net/results

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Drs Harrington and Gibson provide their annual roundup of what they consider the key cardiovascular trials of 2021. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit

This podcast is intended for US healthcare professionals only.

To read a full transcript of this episode or to comment please visit:

https://www.medscape.com/viewarticle/963475

https://www.medscape.com/author/bob-harrington

Antiplatelet Therapy

Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease

https://doi.org/10.1056/NEJMoa2102137

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk

https://doi.org/10.1056/NEJMoa2108749

Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI

https://doi.org/10.1001/jama.2019.8145

Aspirin Versus Clopidogrel for Chronic Maintenance Monotherapy After Percutaneous Coronary Intervention (HOST-EXAM): An Investigator-Initiated, Prospective, Randomised, Open-Label, Multicentre Trial

https://doi.org/10.1016/S0140-6736(21)01063-1

SGLT2 Inhibitors and GLP-1 Agonists

Empagliflozin in Heart Failure with a Preserved Ejection Fraction

https://www.nejm.org/doi/full/10.1056/NEJMoa2107038

Once-Weekly Semaglutide in Adults with Overweight or Obesity

https://www.nejm.org/doi/full/10.1056/NEJMoa2032183

Cardiac Surgery and PCI

Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke

https://doi.org/10.1056/NEJMoa2101897

Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation

https://doi.org/10.1056/NEJMoa2115961

Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery

https://doi.org/10.1056/NEJMoa2112299

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https://www.medscape.com/twic

Questions or feedback? Please contact [email protected]

Instead of trying therapies and hoping for the best, the RECOVERY trial investigators designed randomized trials to test which therapeutics were truly effective for COVID-19. Dr Harrington interviews lead investigator Martin Landray, MB ChB, PhD.

To read a transcript or to comment:

https://www.medscape.com/author/bob-harrington

The Bob Harrington Show is intended for healthcare professionals.

RECOVERY Trial Website and Some Publications

Randomized Evaluation of COVID-19 Therapy

https://www.recoverytrial.net/

Dexamethasone in Hospitalized Patients with Covid-19

https://www.nejm.org/doi/full/10.1056/nejmoa2021436

Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

https://doi.org/10.1016/S0140-6736(20)32013-4

Remdesivir for the Treatment of Covid-19 — Final Report https://www.nejm.org/doi/full/10.1056/nejmoa2007764

Dexamethasone in Hospitalized Patients with Covid-19 https://www.nejm.org/doi/full/10.1056/nejmoa2021436

Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19

https://www.nejm.org/doi/full/10.1056/NEJMoa2022926

Clinical Trials and Informed Consent

The good Clinical Trials Collaborative

https://www.goodtrials.org/

Why do we need some large, simple randomized trials?

https://doi.org/10.1002/sim.4780030421

Assessment of Length and Readability of Informed Consent Documents for COVID-19 Vaccine Trials

http://jamanetwork.com/article.aspx?doi=10.1001/jamanetworkopen.2021.10843

You may also like:

Medscape Editor-in-Chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine

https://www.medscape.com/features/public/machine

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback? Please contact:

[email protected]

A genomics giant with a family history of heart disease and an Olympic athlete accused of cheating are just two of the medical mysteries unraveled by DNA analysis. Bob Harrington interviews Euan Ashley, author of The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them (https://us.macmillan.com/books/9781250234995), who was inspired to write the book after watching an interview between "fellow nerds" Atul Gawande and Barack Obama. To read a transcript or to comment https://www.medscape.com/author/bob-harrington

The Book

The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them https://us.macmillan.com/books/9781250234995

The People

Stephen Quake

Clinical assessment incorporating a personal genome https://doi.org/10.1016/s0140-6736(10)60452-7

Leilani Graham https://www.leilanirgraham.com/

Eero Mäntyranta https://theolympians.co/2018/01/22/eero-mantyranta-the-ruddy-cheeks-and-the-genetic-advantange-of-a-cross-country-skiing-legend-from-finland/

You may also like:

Medscape Editor-in-Chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine

Hear Dr John Mandrola's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic

Questions or feedback, please contact [email protected]

What is the incidence of post-COVID myocarditis and when is it safe to return to play? Bob Harrington and Manesh Patel discuss our evolving understanding of how SARS-CoV-2 effects the hearts of athletes and weekend warriors. To read a transcript or to comment

https://www.medscape.com/author/bob-harrington

Early Studies

Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) https://doi.org/10.1001/jamacardio.2020.3557

Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection https://doi.org/10.1001/jamacardio.2020.4916

Pooled autopsy https://www.medscape.com/viewarticle/944496

Pathological Evidence for SARS-CoV-2 as a Cause of Myocarditis: JACC Review Topic of the Week

https://doi.org/10.1016/j.jacc.2020.11.031

Lake Louise Criteria https://pubmed.ncbi.nlm.nih.gov/30545455/

Recognition and Initial Management of Fulminant Myocarditis

A Scientific Statement From the American Heart Association

https://doi.org/10.1161/CIR.0000000000000745

Long-Haul Post–COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrome: The Swedish Experience

https://doi.org/10.1016/j.jaccas.2021.01.009

You may also like:

Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine

https://www.medscape.com/features/public/machine

Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology

https://www.medscape.com/twic

Questions or feedback, please contact

[email protected]

Bob Harrington and Mike Gibson continue their review of 2020, discussing the 'riddle wrapped in an enigma' that was the COVID-19 pandemic.

The annual tradition continues as did cardiology research despite a pandemic. Trials on fish oils, statins, SGLT2 inhibitors, and antiplatelets are among the selections of Drs Harrington and Gibson.

Three editors of cardiology journals -- Drs Harrington, Yancy, and Nallamothu -- discuss the challenges of maintaining quality during the COVID-19 surge in submissions.

Hematologist Mary Cushman discusses arterial and venous thrombosis issues with SARS-CoV-2 and the role of anticoagulation.

Bob Harrington asks Michelle Albert why mortality rates are so high in minority communities, and whether COVID-19 will lead to meaningful changes in health and social inequities.