The Bob Harrington Show

Do cardiologists from the AFFIRM generation treat AF less aggressively than the EAST-AFNET generation? Bob Harrington and Jonathan Piccini discuss this and upcoming trials on atrial fibrillation.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit:

https://www.medscape.com/author/bob-harrington

A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation (AFFIRM)

https://www.nejm.org/doi/full/10.1056/NEJMoa021328

Early Rhythm-Control Therapy in Patients with Atrial Fibrillation (EAST-AFNET 4)

https://www.nejm.org/doi/10.1056/NEJMoa2019422

Early AF Rhythm-Control Advantage Climbs With Comorbidity Burden: EAST-AFNET4

https://www.medscape.com/viewarticle/979627

Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation (CHANGE-AFIB)

https://clinicaltrials.gov/ct2/show/NCT05130268

Generalizability of the EAST‐AFNET 4 Trial: Assessing Outcomes of Early Rhythm‐Control Therapy in Patients With Atrial Fibrillation

https://doi.org/10.1161/JAHA.121.024214

Early Rhythm Control Therapy for Atrial Fibrillation in Low-Risk Patients

A Nationwide Propensity Score–Weighted Study

https://doi.org/10.7326/M21-4798

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Dr Bob Harrington talks with Drs Michelle Albert and Eldrin Lewis about the Association of Black Cardiologists' diversity scorecard for cardiovascular training programs.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit:

https://www.medscape.com/author/bob-harrington

The ABC Updates its CV DIBS Rankings | Association of Black Cardiologists

https://abcardio.org/recent-news/the-abc-updates-its-cv-dibs-rankings/

FDA Takes Important Steps to Increase Racial and Ethnic Diversity in Clinical Trials

https://www.fda.gov/news-events/press-announcements/fda-takes-important-steps-increase-racial-and-ethnic-diversity-clinical-trials

Gender Diversity in Cardiovascular Clinical Trial Research Begins at the Top

https://www.jacc.org/doi/abs/10.1016/j.jacc.2022.01.001

A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops

https://www.nejm.org/doi/full/10.1056/NEJMoa1717250

At Black Barbershops, BP Reductions Still in Style at 1 Year

https://www.medscape.com/viewarticle/906724

Physician-Patient Racial Concordance and Disparities in Birthing Mortality for Newborns

https://doi.org/10.1073/pnas.1913405117

Racial and Ethnic Diversity at Medical Schools -- Why Aren't We There Yet?

https://www.nejm.org/doi/full/10.1056/NEJMp2105578

Medical School Enrollment More Diverse in 2021

https://www.aamc.org/news-insights/press-releases/medical-school-enrollment-more-diverse-2021#r

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Robert A. Harrington interviews LaShyra Nolen, a medical student and the 2021 recipient of the American Medical Student Association's Racial Justice in Medicine Award.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit:

https://www.medscape.com/author/bob-harrington

How Medical Education Is Missing the Bull's-eye

https://doi.org/10.1056/NEJMp1915891

This Is What I Want To Tell My White Professors When They Ask, 'How Are You Today?'

https://www.huffpost.com/entry/black-medical-student-wants-white-professors-to-know_n_5ed91238c5b6e0feefc26315

Statue of Controversial Surgeon to Be Moved From Central Park

https://www.medscape.com/viewarticle/891413

A Rift Over Carl Linnaeus Shows We Shouldn't Idolise Scientists

https://science.thewire.in/the-sciences/carl-linnaeus-entomological-society-of-america-great-man-theory-progress/

Running Away from Drapetomania: Samuel A. Cartwright, Medicine, and Race in the Antebellum South

https://muse.jhu.edu/article/699875

What Led Chicago to Shutter Dozens of Majority-Black Schools? Racism

https://www.theguardian.com/us-news/2018/dec/06/chicago-public-schools-closures-racism-ghosts-in-the-schoolyard-extract

Call to Action: Structural Racism as a Fundamental Driver of Health Disparities: A Presidential Advisory From the American Heart Association

https://doi.org/10.1161/CIR.0000000000000936

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Bob Harrington interviews fellow cardiologist Jacqueline Tamis-Holland, vice chair of the recent ACC/AHA revascularization guidelines, who takes us inside the process.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit

https://www.medscape.com/author/bob-harrington

2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization

https://doi.org/10.1016/j.jacc.2021.09.006

Evidence Based Medicine: What It Is and What It Isn't

https://doi.org/10.1136/bmj.312.7023.71

2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease:

https://doi.org/10.1161/CIR.0000000000000404

Ticagrelor With or Without Aspirin in High-Risk Patients After PCI

https://doi.org/10.1056/NEJMoa1908419

Surgical Groups Push Back Against New Revascularization Guidelines

https://www.medscape.com/viewarticle/966153

Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity

https://doi.org/10.1161/CIRCULATIONAHA.120.049755

The Invisible Hand — Medical Care During the Pandemic

https://www.nejm.org/doi/full/10.1056/NEJMp2006607

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Robert Harrington, MD, interviews Ziyad Al-Aly, MD, about his recent paper in Nature Medicine focused on the long-term cardiovascular effects of COVID-19.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit

https://www.medscape.com/author/bob-harrington

Robert A. Harrington, MD, Arthur L. Bloomfield Professor; Chair, Department of Medicine, Stanford University; Chair, Department of Medicine, Stanford Medical Center, Stanford, California

Ziyad Al-Aly, MD, Chief of Research and Development, VA St. Louis Health Care System, St. Louis, Missouri

COVID-19 and Long-term Health

Long-Term Cardiovascular Outcomes of COVID-19 https://doi.org/10.1038/s41591-022-01689-3

High-Dimensional Characterization of Post-acute Sequelae of COVID-19

https://doi.org/10.1038/s41586-021-03553-9

Risks of Mental Health Outcomes in People With COVID-19: Cohort Study

https://doi.org/10.1136/bmj-2021-068993

Kidney Outcomes in Long COVID

https://doi.org/10.1681/ASN.2021060734

I'm 26. Coronavirus Sent Me to the Hospital.

https://www.nytimes.com/2020/03/23/opinion/coronavirus-young-people.html

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https://www.medscape.com/twic

Questions or feedback, please contact

[email protected]

Trials on lowering salt consumption and treating hypertension in the community impressed Drs Harrington and Gibson in this discussion of the best public health research of 2021.

This podcast is intended for healthcare professionals only.

To read a transcript or to comment, visit:

https://www.medscape.com/author/bob-harrington

CV Public Health Trials

Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS) https://doi.org/10.1016/j.ahj.2019.12.020

A Cluster Randomized Trial of a Village Doctor-Led Intervention on Blood Pressure Control: China Rural Hypertension Control Project

https://www.abstractsonline.com/pp8/?_ga=2.141042993.2042594723.1635046736-1021258137.1633710264#!/9349/presentation/18155

A Remotely Delivered Hypertension and Lipid Program in 10,000 Patients Across a Diverse Health Care Network

https://www.abstractsonline.com/pp8/?_ga=2.141042993.2042594723.1635046736-1021258137.1633710264#!/9349/presentation/18153

COVID-19 Public Health Trials

Impact of community masking on COVID-19: A cluster-randomized trial in Bangladesh

https://www.poverty-action.org/publication/impact-community-masking-covid-19-cluster-randomized-trial-bangladesh

Dexamethasone in Hospitalized Patients with Covid-19

https://doi.org/10.1056/NEJMoa2021436

Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19

https://jamanetwork.com/journals/jama/fullarticle/2775280

The Recovery Trial Initiative

https://www.recoverytrial.net/results

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Drs Harrington and Gibson provide their annual roundup of what they consider the key cardiovascular trials of 2021. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit

This podcast is intended for US healthcare professionals only.

To read a full transcript of this episode or to comment please visit:

https://www.medscape.com/viewarticle/963475

https://www.medscape.com/author/bob-harrington

Antiplatelet Therapy

Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease

https://doi.org/10.1056/NEJMoa2102137

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk

https://doi.org/10.1056/NEJMoa2108749

Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI

https://doi.org/10.1001/jama.2019.8145

Aspirin Versus Clopidogrel for Chronic Maintenance Monotherapy After Percutaneous Coronary Intervention (HOST-EXAM): An Investigator-Initiated, Prospective, Randomised, Open-Label, Multicentre Trial

https://doi.org/10.1016/S0140-6736(21)01063-1

SGLT2 Inhibitors and GLP-1 Agonists

Empagliflozin in Heart Failure with a Preserved Ejection Fraction

https://www.nejm.org/doi/full/10.1056/NEJMoa2107038

Once-Weekly Semaglutide in Adults with Overweight or Obesity

https://www.nejm.org/doi/full/10.1056/NEJMoa2032183

Cardiac Surgery and PCI

Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke

https://doi.org/10.1056/NEJMoa2101897

Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation

https://doi.org/10.1056/NEJMoa2115961

Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery

https://doi.org/10.1056/NEJMoa2112299

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Questions or feedback? Please contact [email protected]

Instead of trying therapies and hoping for the best, the RECOVERY trial investigators designed randomized trials to test which therapeutics were truly effective for COVID-19. Dr Harrington interviews lead investigator Martin Landray, MB ChB, PhD.

To read a transcript or to comment:

https://www.medscape.com/author/bob-harrington

The Bob Harrington Show is intended for healthcare professionals.

RECOVERY Trial Website and Some Publications

Randomized Evaluation of COVID-19 Therapy

https://www.recoverytrial.net/

Dexamethasone in Hospitalized Patients with Covid-19

https://www.nejm.org/doi/full/10.1056/nejmoa2021436

Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

https://doi.org/10.1016/S0140-6736(20)32013-4

Remdesivir for the Treatment of Covid-19 — Final Report https://www.nejm.org/doi/full/10.1056/nejmoa2007764

Dexamethasone in Hospitalized Patients with Covid-19 https://www.nejm.org/doi/full/10.1056/nejmoa2021436

Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19

https://www.nejm.org/doi/full/10.1056/NEJMoa2022926

Clinical Trials and Informed Consent

The good Clinical Trials Collaborative

https://www.goodtrials.org/

Why do we need some large, simple randomized trials?

https://doi.org/10.1002/sim.4780030421

Assessment of Length and Readability of Informed Consent Documents for COVID-19 Vaccine Trials

http://jamanetwork.com/article.aspx?doi=10.1001/jamanetworkopen.2021.10843

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Questions or feedback? Please contact:

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A genomics giant with a family history of heart disease and an Olympic athlete accused of cheating are just two of the medical mysteries unraveled by DNA analysis. Bob Harrington interviews Euan Ashley, author of The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them (https://us.macmillan.com/books/9781250234995), who was inspired to write the book after watching an interview between "fellow nerds" Atul Gawande and Barack Obama. To read a transcript or to comment https://www.medscape.com/author/bob-harrington

The Book

The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them https://us.macmillan.com/books/9781250234995

The People

Stephen Quake

Clinical assessment incorporating a personal genome https://doi.org/10.1016/s0140-6736(10)60452-7

Leilani Graham https://www.leilanirgraham.com/

Eero Mäntyranta https://theolympians.co/2018/01/22/eero-mantyranta-the-ruddy-cheeks-and-the-genetic-advantange-of-a-cross-country-skiing-legend-from-finland/

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Questions or feedback, please contact [email protected]

What is the incidence of post-COVID myocarditis and when is it safe to return to play? Bob Harrington and Manesh Patel discuss our evolving understanding of how SARS-CoV-2 effects the hearts of athletes and weekend warriors. To read a transcript or to comment

https://www.medscape.com/author/bob-harrington

Early Studies

Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) https://doi.org/10.1001/jamacardio.2020.3557

Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection https://doi.org/10.1001/jamacardio.2020.4916

Pooled autopsy https://www.medscape.com/viewarticle/944496

Pathological Evidence for SARS-CoV-2 as a Cause of Myocarditis: JACC Review Topic of the Week

https://doi.org/10.1016/j.jacc.2020.11.031

Lake Louise Criteria https://pubmed.ncbi.nlm.nih.gov/30545455/

Recognition and Initial Management of Fulminant Myocarditis

A Scientific Statement From the American Heart Association

https://doi.org/10.1161/CIR.0000000000000745

Long-Haul Post–COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrome: The Swedish Experience

https://doi.org/10.1016/j.jaccas.2021.01.009

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https://www.medscape.com/twic

Questions or feedback, please contact

[email protected]