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Bob Harrington, Erin Michos, and Brahmajee Nallamothu discuss how the publish or perish culture can lead to sloppy research and the need for alternative models to measure success in academic medicine.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
With Great Power Comes Great Responsibility
Big Data Research From the National Inpatient Sample https://doi.org/10.1161/CIRCOUTCOMES.117.003846
Adherence to Methodological Standards in Research Using the National Inpatient Sample
https://doi.org/10.1001/jama.2017.17653
Publish or Perish: Where are we heading?
https://pubmed.ncbi.nlm.nih.gov/24778659
The Kardashian Index of Cardiologists: Celebrities or Experts? https://doi.org/10.1016/j.jaccas.2019.11.068
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Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact [email protected]
Bob Harrington and Mike Gibson discuss two of the hottest topics in cardiology and medicine for 2023: a proposed alternative to the maintenance of certification process, and artificial intelligence.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit
https://www.medscape.com/author/bob-harrington
Cardiovascular Organizations Pursue New, Independent Medical Board
https://www.acc.org/About-ACC/Press-Releases/2023/09/21/15/02/Cardiovascular-Organizations-Pursue-New-Independent-Medical-Board
The National Board of Physicians and Surgeons
https://nbpas.org/
Level of Scientific Evidence Underlying the Current American College of Cardiology/American Heart Association Clinical Practice Guidelines
https://doi.org/10.1161/CIRCOUTCOMES.118.005293
Validation of a Speech Analysis Application to Detect Worsening Heart Failure Events in Ambulatory Heart Failure Patients https://www.abstractsonline.com/pp8/?_ga=2.17782015.7532578.1693882428-1949139275.1663003561#!/10871/presentation/16568
A systematic review shows no performance benefit of machine learning over logistic regression for clinical prediction models
https://doi.org/10.1016/j.jclinepi.2019.02.004
Recognizing a ruler instead of a cancer
https://menloml.com/2020/01/11/recognizing-a-ruler-instead-of-a-cancer/
The Geographic Bias in Medical AI Tools
https://hai.stanford.edu/news/geographic-bias-medical-ai-tools
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Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact
For this year's review, Bob Harrington and Mike Gibson revisit the major cardiology conferences -- from ACC in New Orleans to AHA in Philly.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit:
https://www.medscape.com/author/bob-harrington
ACC 2023 Top Trials
- Bempedoic Acid Cuts CV Events in Statin-Intolerant Patients: CLEAR Outcomes https://www.medscape.com/viewarticle/989100
- Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients
- Phase 2b Randomized Trial of the Oral PCSK9 Inhibitor MK-0616 https://www.jacc.org/doi/10.1016/j.jacc.2023.02.018
ACC/WCC 2023 Collection Page https://www.medscape.com/viewcollection/36966
ESC 2023 Top Trials
- Wegovy Scores HFpEF Benefits in People With Obesity https://www.medscape.com/viewarticle/995844
- Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity https://www.nejm.org/doi/full/10.1056/NEJMoa2306963
- Acoramidis Shows Encouraging Results in ATTR Cardiomyopathy https://www.medscape.com/viewarticle/995883
ESC 2023 Collection Page https://www.medscape.com/viewcollection/36988
AHA 2023 Top Trials
- Semaglutide 'A New Pathway' to CVD Risk Reduction: SELECT https://www.medscape.com/viewarticle/998373
- Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes https://www.nejm.org/doi/full/10.1056/NEJMoa2307563
- Bariatric Surgery is Associated With Improved Coronary Microvascular Function and Cardiorespiratory Fitness in Patients With Ischemia and Non-Obstructive Coronary Arteries https://www.ahajournals.org/doi/10.1161/circ.148.suppl_1.18949
- Angioplasty Finally Proven Beneficial in Stable Angina: ORBITA-2 https://www.medscape.com/s/viewarticle/998375
- A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina https://www.nejm.org/doi/full/10.1056/NEJMoa2310610
- Impressive Bleeding Profile With Factor XI Inhibitor in AF: AZALEA https://www.medscape.com/viewarticle/998418
- Promising First Results With DNA Editing to Lower LDL https://www.medscape.com/s/viewarticle/998719
- Single Injection Reduces Blood Pressure for 6 Months: KARDIA-1 https://www.medscape.com/viewarticle/998666
AHA 2023 Collection Page https://www.medscape.com/viewcollection/37277
Other Mentions
- N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects https://www.nejm.org/doi/full/10.1056/NEJMc2031173
- Rimonabant: From RIO to Ban https://doi.org/10.1155%2F2011%2F432607
- Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial https://doi.org/10.1016/S0140-6736(17)32714-9
- Asundexian Phase 3 AF Study Halted for Lack of Efficacy https://www.medscape.com/viewarticle/998665
- Challenges in the Design and Interpretation of Noninferiority Trials https://www.nejm.org/doi/full/10.1056/nejmra1510063
- Milvexian for the Prevention of Venous Thromboembolism https://www.nejm.org/doi/full/10.1056/NEJMoa2113194
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Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact [email protected]
Bob Harrington and Manesh Patel discuss sudden cardiac death in athletes and the importance of the chain of survival.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
COVID and the Athlete's Heart
https://www.medscape.com/viewarticle/945282
Outcomes Registry for Cardiac Conditions in Athletes
https://doi.org/10.1161/JAHA.122.029052
2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy
https://doi.org/10.1161/CIR.0000000000000937
Point-of-care screening for HFrEF using artificial intelligence during ECG-enabled stethoscope examination
https://doi.org/10.1016/s2589-7500(21)00256-9
International recommendations for electrocardiographic interpretation in athletes
https://doi.org/10.1093/eurheartj/ehw631
Elevation of Cardiac Troponins After Endurance Running Competitions
https://doi.org/10.1161/CIRCULATIONAHA.118.034655
Vigorous Exercise in Patients With Hypertrophic Cardiomyopathy
https://doi.org/10.1001/jamacardio.2023.1042
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Preamble, Principles, and General Considerations
https://doi.org/10.1161/CIR.0000000000000236
RACE-CARS Trial
https://racecarstrial.org/
AHA CPR Resources
https://cpr.heart.org/en/cpr-courses-and-kits/hands-only-cpr
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Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic
Questions or feedback, please contact [email protected]
Bob Harrington interviews Jag Singh about the COVID journey that led to his book, Future Care: Sensors, Artificial Intelligence, and the Reinvention of Medicine.
This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington
Future Care: Sensors, Artificial Intelligence, and the Reinvention of Medicine. https://www.jagsinghmd.com/book
COVID-19 Hits Physician Couple: Dramatically Different Responses
https://www.medscape.com/viewarticle/928530
Smartwatch Electrocardiogram and Artificial Intelligence for Assessing Cardiac-Rhythm Safety of Drug Therapy in the COVID-19 Pandemic. The QT-logs study
https://doi.org/10.1016/j.ijcard.2021.01.002
The Care of the Patient
https://doi.org/10.1001/jama.1927.02680380001001
Advancements and future directions in the teamwork, targets, technology, and tight control-the 4T study: improving clinical outcomes in newly diagnosed pediatric type 1 diabetes
https://doi.org/10.1097/mop.0000000000001140
Social determinants of telemedicine utilization in ambulatory cardiovascular patients during the COVID-19 pandemic
https://doi.org/10.1093/ehjdh/ztab039
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Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact: [email protected]
Robert Harrington, MD and Jenine John, a cardiologist and machine learning research fellow discuss what you need to know about AI and ML in healthcare and where to find some helpful resources.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington
'One Brave Idea' Recipient on Predicting Who Will Develop CAD
https://www.medscape.com/viewarticle/874536
Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection
https://doi.org/10.1161/circulationaha.121.058696
Application of Artificial Intelligence to the Electrocardiogram
https://doi.org/10.1093/eurheartj/ehab649
Using Machine Learning to Detect Problems in ECG Data Collection
https://www.cinc.org/archives/2011/pdf/0437.pdf
Age and Sex Estimation Using Artificial Intelligence From Standard 12-Lead ECGs
https://doi.org/10.1161/CIRCEP.119.007284
External Validation of a Widely Implemented Proprietary Sepsis Prediction Model in Hospitalized Patients
http://jamanetwork.com/article.aspx?doi=10.1001/jamainternmed.2021.2626
Sepsis Predictor Tool Falls Short in
Emergency Setting
https://www.medscape.com/viewarticle/982534
Dissecting Racial Bias in an Algorithm Used to Manage the Health of Populations
https://doi.org/10.1126/science.aax2342
Geographic Distribution of US Cohorts Used to Train Deep Learning Algorithms https://jamanetwork.com/journals/jama/fullarticle/2770833
Can Medical Algorithms Be Fair? Three Ethical Quandaries and One Dilemma
https://doi.org/10.1136/bmjhci-2021-100445
Healthcare Machine Learning: Getting Started
https://medium.com/@jeninej/healthcare-machine-learning-getting-started-761a7dbb63a2
What Clinicians Should Know About Healthcare AI, Part 1: Why Care About AI?
https://medium.com/@jeninej/what-clinicians-should-know-about-healthcare-ai-part-1-why-care-about-ai-aba6a06f696d
AI in Healthcare Specialization
https://www.coursera.org/specializations/ai-healthcare
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Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine: https://www.medscape.com/features/public/machine
Hear John Mandrola, MD's, summary and perspective on the top cardiology news each week, on This Week in Cardiology: https://www.medscape.com/twic
Questions or feedback, please contact: [email protected]
Bob Harrington talks to two former colleagues who made a mid- and senior-career switch to pharma and digital tech, respectively. How did they make this decision and what advice do they have for others?
This podcast is intended for healthcare professionals only.
To read a transcript or to comment
https://www.medscape.com/author/bob-harrington
Jeff Bezos - Regret Minimization https://www.youtube.com/watch?v=-qPii5ACVYw
You may also like:
Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact
Trials on heart failure, hypertension and lipid-lowering drugs, and the evolution of antithrombin and antiplatelet therapy are discussed in part 2 of cardiologists Bob Harrington and Mike Gibson's annual review.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit
https://www.medscape.com/author/bob-harrington
Lipid Lowering
Safety, Tolerability and Efficacy of Up-Titration of Guideline-Directed Medical Therapies for Acute Heart Failure (STRONG-HF): A Multinational, Open-Label, Randomised, Trial
https://doi.org/10.1016/S0140-6736(22)02076-1
Why Combination Lipid-Lowering Therapy Should Be Considered Early in the Treatment of Elevated LDL-C for CV Risk Reduction
https://www.acc.org/latest-in-cardiology/articles/2022/06/01/12/11/why-combination-lipid-lowering-therapy-should-be-considered
Incidental Coronary Artery Calcium: Opportunistic Screening of Prior Non-gated Chest CTs to Improve Statin Rates (NOTIFY-1 Project)
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.062746
Equivalent Impact of Elevated Lipoprotein(a) and Familial Hypercholesterolemia in Patients With Atherosclerotic Cardiovascular Disease
https://doi.org/10.1016/j.jacc.2022.09.021
Comparative Effects of Low-Dose Rosuvastatin, Placebo and Dietary Supplements on Lipids and Inflammatory Biomarkers
https://doi.org/10.1016/j.jacc.2022.10.013
Antihypertensive Drugs
No Survival Advantage for Either Torsemide or Furosemide in HF: TRANSFORM-HF
https://www.medscape.com/viewarticle/983611
Chlorthalidone vs. Hydrochlorothiazide for Hypertension–Cardiovascular Events
www.nejm.org/doi/full/10.1056/NEJMoa2212270
Antiplatelets
Duration of Antiplatelet Therapy After Complex Percutaneous Coronary Intervention in Patients at High Bleeding Risk: A MASTER DAPT Trial Sub-analysis
https://doi.org/10.1093/eurheartj/ehac284
PANTHER: Should Clopidogrel Become the 'New Aspirin' in CAD?
https://www.medscape.com/viewarticle/980117
P2Y12 Inhibitor Versus Aspirin Monotherapy for Secondary Prevention of Cardiovascular Events: Meta-analysis of Randomized Trials
https://doi.org/10.1093/ehjopen/oeac019
Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes
https://doi.org/10.1056/nejmoa0904327
TCT-320 Pharmacokinetic and Pharmacodynamic Profile of PL-ASA, a Novel Phospholipid-Aspirin Complex Liquid Formulation, Compared to Enteric-Coated Aspirin at an 81-mg Dose – Results From a Prospective, Randomized, Crossover Study
https://www.jacc.org/doi/10.1016/j.jacc.2021.09.1173
Pharmacokinetic and Pharmacodynamic Profile of a Novel Phospholipid Aspirin Formulation
https://europepmc.org/article/pmc/pmc8773391
Antithrombins/Factor XI
Rivaroxaban in Patients With a Recent Acute Coronary Syndrome
https://www.nejm.org/doi/full/10.1056/nejmoa1112277
Genetically Determined FXI (Factor XI) Levels and Risk of Stroke
https://doi.org/10.1161/strokeaha.118.022792
Factor XIa Inhibition With Asundexian After Acute Non-cardioembolic Ischaemic Stroke (PACIFIC-Stroke): an International, Randomised, Double-Blind, Placebo-Controlled, Phase 2b Trial
https://doi.org/10.1016/s0140-6736(22)01588-4
Safety of the Oral Factor Xia Inhibitor Asundexian Compared With Apixaban in Patients With Atrial Fibrillation (PACIFIC-AF): a Multicentre, Randomised, Double-Blind, Double-Dummy, Dose-Finding Phase 2 Study
https://doi.org/10.1016/S0140-6736(22)00456-1
A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction
https://doi.org/10.1161/circulationaha.122.061612
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Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback? Please contact
In part 1 of their annual review, cardiologists Bob Harrington and Mike Gibson discuss in-person meetings, wearables and AI, COVID lessons for medical research, and the growth of RCTs from China.
This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit
https://www.medscape.com/author/bob-harrington
COVID Therapies
Therapeutic Anticoagulation With Heparin in Noncritically Ill Patients With Covid-19
https://www.nejm.org/doi/full/10.1056/NEJMoa2105911
Effect of Intermediate/High Versus Low Dose Heparin on the Thromboembolic and Hemorrhagic Risk of Unvaccinated COVID-19 Patients in the Emergency Department
https://doi.org/10.1186/s12873-022-00668-8
Two Old Meds and a DOAC a Bust Across Range of COVID Severity: The ACT Trials
https://www.medscape.com/viewarticle/980049
Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial
http://jamanetwork.com/article.aspx?doi=10.1001/jama.2022.18590
FDA Halts Use of Some COVID Monoclonal Antibodies Due to Omicron
https://www.medscape.com/viewarticle/967210
CT Surgeons Rise to Challenge, Lead Way in COVID Clinical Trials
https://www.sts.org/publications/sts-news/ct-surgeons-rise-challenge-lead-way-covid-clinical-trials
What Do We Know About Long COVID: A Cardiovascular Focus
https://www.medscape.com/viewarticle/981435
COVID-19 and the Heart: Is Cardiology Ready?
https://www.medscape.com/viewarticle/969206
The Stanford RECOVER Trial
https://recovercovid.org/
The Heroes Study
https://heroesresearch.org/
Artificial Intelligence
Age and Sex Estimation Using Artificial Intelligence From Standard 12-Lead ECGs
https://doi.org/10.1161/CIRCEP.119.007284
The Heartline Study
https://www.heartline.com/about
Evolution of Single-Lead ECG for STEMI Detection Using a Deep Learning Approach
https://doi.org/10.1016/j.ijcard.2021.11.039
Recognizing a Ruler Instead of a Cancer
https://menloml.com/2020/01/11/recognizing-a-ruler-instead-of-a-cancer/
Machine Learning Did Not Beat Logistic Regression in Time Series Prediction for Severe Asthma Exacerbations
https://doi.org/10.1038/s41598-022-24909-9
A Systematic Review Shows No Performance Benefit of Machine Learning Over Logistic Regression for Clinical Prediction Models
https://doi.org/10.1016/j.jclinepi.2019.02.004.
Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection
https://doi.org/10.1161/circulationaha.121.058696
Detection of Hypertrophic Cardiomyopathy Using a Convolutional Neural Network-Enabled Electrocardiogram
https://doi.org/10.1016/j.jacc.2019.12.030
Here's Why We're Not Prepared for the Next Wave of Biotech Innovation (by Matthew Herper)
https://www.statnews.com/2022/11/03/why-were-not-prepared-for-next-wave-of-biotech-innovation/
RCTs from China
Bivalirudin Plus a High-Dose Infusion Versus Heparin Monotherapy in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Randomised Trial
https://doi.org/10.1016/S0140-6736(22)01999-7
Chinese Herbal Medicine May Offer Benefits in STEMI: CTS-AMI
https://www.medscape.com/viewarticle/983619
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Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback? Please contact
Drs Bob Harrington and Betty Raman discuss the cardiovascular impact and long-term sequelae of COVID-19, the potential biology behind multisystem effects, and ongoing research.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit
https://www.medscape.com/author/bob-harrington
Medium-term Effects of SARS-CoV-2 Infection on Multiple Vital Organs, Exercise Capacity, Cognition, Quality of Life and Mental Health, Post-Hospital Discharge
https://doi.org/10.1016/j.eclinm.2020.100683
Prevalence and Impact of Myocardial Injury in Patients Hospitalized With COVID-19 Infection
https://doi.org/10.1016%2Fj.jacc.2020.06.007
Outcomes Among Confirmed Cases and a Matched Comparison Group in the Long-COVID in Scotland Study https://doi.org/10.1038/s41467-022-33415-5
Long COVID: Post-Acute Sequelae of COVID-19 With a Cardiovascular Focus
https://doi.org/10.1093/eurheartj/ehac031
Cardiovascular Disease and COVID-19: A Consensus Paper From the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in Collaboration With the European Heart Rhythm Association (EHRA)
https://doi.org/10.1093/cvr/cvab298
Infection of Brain Pericytes Underlying Neuropathology of COVID-19 Patients
https://doi.org/10.3390/ijms222111622
COVID-19 and Fat Embolism: A Hypothesis to Explain the Severe Clinical Outcome in people With Obesity
https://pubmed.ncbi.nlm.nih.gov/32514077
Association Between Epstein-Barr-Virus Reactivation and Development of Long-COVID Fatigue
https://doi.org/10.1111/all.15471
Activation or Exhaustion of CD8+ T Cells in Patients With COVID-19
https://doi.org/10.1038/s41423-021-00750-4
Skeletal Muscle Alterations in Patients With Acute COVID-19 and Post-Acute Sequelae of COVID-19
https://doi.org/10.1002/jcsm.12896
Gut Microbiota Dynamics in a Prospective Cohort of Patients With Post-Acute COVID-19 Syndrome
http://dx.doi.org/10.1136/gutjnl-2021-325989
COVID-Vaccine Myocarditis: Rare, Mild, and Usually a Guy Thing
https://www.medscape.com/viewarticle/966244
Myocardial Injury Pattern at MRI in COVID-19 Vaccine–Associated Myocarditis
https://doi.org/10.1148/radiol.212559
Could Perturbation of Gut Microbiota Possibly Exacerbate the Severity of COVID-19 via Cytokine Storm?
https://doi.org/10.3389/fimmu.2020.607734
Myocarditis Associated With COVID-19 Vaccination
https://doi.org/10.1161/CIRCIMAGING.121.013236
COVID and the Athlete's Heart
https://www.medscape.com/viewarticle/945282
COVID-19 and the Heart: Is Cardiology Ready?
https://www.medscape.com/viewarticle/969206
Lung Abnormalities Depicted With Hyperpolarized Xenon MRI in Patients With Long COVID
https://doi.org/10.1148/radiol.220069
Long COVID Resource Center
https://www.medscape.com/resource/long-covid
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Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine.
Hear John Mandrola, MD's, summary and perspective on the top cardiology news each week on This Week in Cardiology.
Questions or feedback, please contact [email protected]
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