His main commemoration is on June 2; today we commemorate the return of his holy relics to Constantinople.

Nicephoros was Patriarch during the time of the iconoclasts, and openly opposed the Emperor Leo the Armenian's heretical policies. For this he was exiled to a monastery on the island of Prochonis, which he himself had built when Patriarch. After living there for thirteen years, he reposed around 827. In time, the iconoclast Emperors died, and the Emperor Michael, with his mother Theodora, came to the Imperial throne in 842; they appointed Methodios, a defender of the icons, as Patriarch. In 846, the incorrupt relics of St Nicephoros were returned to Constantinople and placed first in the Hagia Sophia, then in the Church of the Holy Apostles. The saint had been driven from Constantinople on March 13, and his relics were returned there on March 13, nineteen years later to the day.