Translational Medicine

Dr George Warimwe talks about his research on Rift Valley Fever. Dr George Warimwe is working with the International Livestock Research Institute (ILRI) A Centre of Excellence in Africa, and the Jenner Institute to develop a vaccine against Rift Valley Fever in humans, that will also be useful as a vaccination against the disease in livestock.

Dr Katharine Owen talks about the different types of Diabetes in young adults. There are more forms of diabetes than the commonly known type 1 and type 2. Dr Katherine Owen investigates the different characteristics of monogenic diabetes with the aim of creating systematic diagnostics for aetiology of diabetes, and implementing that in clinical care. The ultimate aim is to promote personalized medicine for everybody with diabetes.

Dr Patrick Pollard tells us about his research on cancer metabolism. Cancer cells produce energy predominately by a high rate of glycolysis. It has been suggested that this change in metabolism is a fundamental cause of cancer. Dr Patrick Pollard aims to elucidate the alternative metabolic strategies used by cancer cells to proliferate, even under conditions of stress.

Professor Mark McCarthy tells us how genomics helps us understand diabetes. Professor Mark McCarthy (Robert Turner Professor of Diabetes) leads a multidisciplinary research team including clinicians, nurses and lab-based research staff. One of their major focuses lies in translating gene identification and genetic information into advances in functional understanding and clinical management.

Dr Richard Antrobus talks about his research in the development of a universal flu vaccine. Dr Antrobus has been conducting a Phase I study of a Universal Vaccine for Influenza. Progress so far indicates that this approach induces a potent T cell response, and Dr Antrobus is currently assessing whether this response is equally potent in the elderly - one of the 'at risk' groups of the Influenza virus.

Dr Arturo Reyes-Sandoval tells us about his research on a vaccine against Plasmodium vivax. Dr Reyes Sandoval aims to develop a novel malaria vaccine against Plasmodium vivax, one of the four malaria parasites that affect humans. P. vivax is found in Africa, Asia, Latin America and the Western Pacific. 40 percent of the world's population is exposed to the disease that is responsible for around 130 to 350 million clinical cases every year.

Colin Baigent, Professor of Epidemiology, Clinical Trial Service Unit, Oxford, talks about why the drug Statin saves lives.

Dr Helen Fletcher talks about progress in the development of a vaccine against tuberculosis. Dr Helen Fletcher works on multi-partner projects to discover biomarkers of protection from TB disease, develop clinical trials capacity in Africa, and develop new vaccines for TB. Dr Fletcher has also developed her own research programme on transcriptional profiling of immune responses following both TB and malaria vaccination.

Dr Opher Gileadi tells us how cells maintain genome integrity and how we can use it in our fight against cancer. Dr Opher Gileadi studies the structure and chemical biology of proteins involved in DNA repair and in recovery from DNA damage. DNA damage can be both a cause of cancer and a tool in fighting cancer, and the work aims to uncover ways to better target and destroy cancer cells.

Dr Kerstin Luhn talks about her research on Dengue infection. Dr Luhn is investigating the effect of Dengue virus infection on innate immune cells to understand why Dengue, unlike other viral infections, is associated with high levels of immunopathology. An in vitro Dengue model is used and results are confirmed with Dengue patient samples from a cohort in Vietnam.