Program notes:

0:40 Alteplase after stroke

1:40 Expand time window

2:40 Imaging crucial in use

3:20 Use of health care and mortality in those with dementia

4:20 Women used much less healthcare

5:20 Focus on prevention in women

5:50 IVF outcomes and weight loss

6:50 Did not appear to increase success with IVF

7:45 Ultraprocessed foods versus minimally processed foods

8:45 Randomized to one diet or the other for 8 weeks

9:45 Minimally processed foods improved risk factors

10:45 Short period of study

11:42 End

Program notes:

0:40 Screening young adults for CRC

1:40 Four different screening options

2:41 Awareness issue

3:40 "Yuck" factor associated

4:34 Persistent Covid infections and variants

5:35 Who ends up with variants?

6:35 Did not render more infectious

7:35 Humans as mixing vessels

7:50 How do men and women respond to antithrombotics

8:50 15% reduction in MI

9:58 Long term contraceptives free and uptake

10:58 48% of pregnancies in North America unintended

11:58 Increase in any type of contraception

12:38 Cost is an important contributor

13:24 End

Program notes:

0:44 Flu consequences for young children

1:44 Fulminant course

2:44 16 kids of total unvaccinated

3:10 HPV, T-cell receptor signaling and SCC

4:10 Unresectable disease

5:10 Thought virus facilitated

6:10 Target in recurrent or metastatic disease

6:26 Nonpharmacologic intervention in older adults to improve cognition

7:26 More intensive program a little better

8:26 Eat better, exercise more and use your mind

9:15 Polygenic risk score for obesity

10:15 Explained variance in cohorts

11:15 At birth adds a bit of value

12:08 End

Program notes:

0:40 Human Phenotype project

1:43 Metabolomics

2:42 25 year follow up

3:43 Two control groups

4:00 CBT via telehealth or online

5:00 2000 people with chronic pain

6:00 Completion rate for videos lower

6:50 RNA analysis in cancer molecular diagnostics

7:50 4.8% failure rate

8:50 CNS or blood cancers primarily

9:25 Middle age exposure to air pollution and later cognition

10:25 Poorer processing speed earlier in life

11:58 End

Program notes:

0:44 Reanimating hearts for transplant

1:44 Allow heart to sit for two to four minutes

2:34 Outcomes in DCIS without surgery

3:34 Free of breast cancer six months after diagnosis

4:34 Numbers who went on to develop invasive disease low

5:34 May change how we approach DCIS

6:09 Suicidality around the world in older adults

7:09 Guns, pesticides, hanging

8:10 Increase primary care diagnosis of OUD

9:10 Three clinics in four U.S. states

10:10 Six million adults with OUD

11:10 Many physicians unaware of medicines

12:43 End

Program notes:

0:40 AHA risk calculator in various ethnicities

1:40 Works well in all of them

2:40 Women and ethnicities

3:00 Hepatitis C screening in EDs

4:01 Many ethnicities represented

5:01 Identified as having the virus

6:01 Once they tested only 24% were referred

7:01 It was free testing

7:40 Failing US children

8:41 78% more likely to die in the US

9:41 Some of these are preventable

10:24 Life expectancy after the pandemic

11:24 Remains almost a year deficit

12:24 Deaths from overdose declining

13:17 End

Program notes:

0:40 A novel way to help aphasia after a stroke

1:40 C7 nerve ligation

2:42 Somatosensory function versus speech processing

3:36 Substandard anticancer medications

4:40 Tested many using HPLC

5:40 Alarming that one in six is impacted

6:40 Paying out of pocket

7:38 New type of medicine for treatment resistant hypertension

8:38 Need to follow electrolytes

9:00 ED boarding for elderly

10:00 Length of stay increased

11:00 Elderly more likely to suffer complications

12:00 CMS program for all inclusive care for elderly

12:49 End

Program notes:

0:40 Stem cells for type 1 diabetes

1:40 None had hypoglycemia afterwards

2:40 Autologous stem cells?

3:20 Oral GLP-1 agonist

4:20 Primary endpoint HbA1c reduction

5:20 Weight loss modest

6:20 Injectable GLP-1 plus an amylin analogue

7:20 Both those with diabetes and those without

8:20 No increased safety events

8:40 Mental health hospitalizations in adolescents

9:40 KID database

10:40 Females accounting for increase

11:40 67% of hospitalizations

12:57 End

Program notes:

0:35 Screen time trajectories in adolescents

1:33 31% had increasing addictive use trajectories

2:31 Females more involved in social media

3:06 Cannabis and CV risk

4:06 Smoking or using other products

5:06 Mechanisms include oxidative stress

6:06 Haven't regulated

6:28 Tau PET imaging in Alzheimer's

7:28 90% of tau positivity concurs with AB

8:30 Will blood test obviate?

9:30 Imaging to detect spread

9:43 CT perfusion for death by neurological criteria

10:43 Validation threshold 98%

11:43 Maybe adding another technique

12:43 End

This week's topics include family affluence and telomeres in children, gut bugs and respiratory illness in children, heat illness and homelessness, and low potassium diets and hypertension and diabetes.

Program notes:

1:05 Heat illness and homelessness

2:05 No access to water

3:05 More likely in southern states

3:20 Telomere length, family affluence and cortisol

4:20 High affluence had longer telomeres

5:20 Cortisol may need to be measured over longer time interval

6:20 Dietary patterns, sodium reduction, hypertension and those with diabetes

7:20 Dash-D with low sodium

8:20 Low sodium is good

9:14 Neonatal gut microbiota and lRTIs

10:14 Half of children born vaginally

11:15 First to look in newborns

12:39 End