Tucker Goodrich: Debugging Life

We look at a paper about the process of how the fats in seed oils become toxic, and what effects those toxins can have.

This paper is a broad overview of the related disease processes, which we will discuss to further understand how one thing can be driving many different disease processes.

"The study of lipid peroxidation (LPO) processes has become a rapidly growing field in medicine and biology, based on increasing evidence that LPO is involved in the development of many chronic diseases, e.g. [references removed]

(1) Asthma

(2) Atherosclerosis

(3) Alzheimer's disease

(4) Rheumatoid arthritis

(5) Burn injury

(6) Cataractogenesis

(7) Diabetes

(8) Endotoxin liver injury

(9) Multiple sclerosis

(10)Myocardial infarction

(11)Organ transplantation

(12)Parkinson disease

(13)Psoriasis

(14)Reperfusion injury

(15)Stroke

(16)Aging

"The obvious involvement of LPO processes in the majority of severe diseases stimulated worldwide efforts to elucidate the mechanisms of their generation.

"These efforts are expressed in the exploding flood of papers, conference reports, review articles (see above) and books dealing with LPO. This paper is, therefore, not intended to add to these reviews but rather to address aspects previously overlooked: the dominant role of linoleic acid (LA) in LPO and the application of a combination of modern separation and identification techniques to isolate LPO products. Knowledge of these products provides insight into the mechanisms of their generation and offers a better understanding of the diseases in which LPO is involved." (Spiteller 1998)

Matt Quinn

https://twitter.com/Mqsley

https://www.mquinn.online/

TL;DR Here's what I am working on:

I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here​

I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this

I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here

In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here

I have failed at so so so many things - read about them here

https://www.mquinn.online/

_______________________________________

Dr. Brian Kerley

https://www.seedoilrebellion.com/

https://twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?

Check out the Seedy app!

https://www.seedyapp.com/

Tucker Goodrich

Substack: https://tuckergoodrich.substack.com/

Twitter: https://twitter.com/TuckerGoodrich

Youtube: https://www.youtube.com/tuckergoodrich0

Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825

Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y

Podcast: https://sites.libsyn.com/408758

Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/

_______________________________________

Episode 14 Post Script: Matt Has a Surprising Easter Egg

https://youtu.be/1D17vUvbHhk

Spiteller, G. (1998). Linoleic Acid Peroxidation—The Dominant Lipid Peroxidation Process in Low Density Lipoprotein—And Its Relationship to Chronic Diseases. Chemistry and Physics of Lipids, 95(2), 105–162. https://doi.org/10.1016/S0009-3084(98)00091-7

We are honorored to be joined by Prof. A. J. Hulbert, noted zoologist and author of Omega Balance: Nutritional Power for a Happier, Healthier Life.

"In Omega Balance, noted scientist Anthony J. Hulbert explains how the balance between [Omega-3 and omega-6 fatty acids] in the human food chain has changed over the last half-century and the very serious negative health impacts this imbalance has created.

An imbalance of these omega fats contributes to increased rates of obesity, diabetes, cardiovascular diseases, allergies, asthma, as well as cancer and a variety of other inflammatory diseases. Omega balance is also important for normal brain function, and an imbalance in these fatty acids is associated with depression, mood disorders, and neurodegenerative diseases.

Hulbert provides extensive information on the omega balance of different foods and discusses fascinating details about human evolution, dietary changes throughout history, the effect of diet on human development and physiological processes, and more. He investigates the paleo diet of our ancestors and describes the dramatic changes that have accompanied the increased ultra-processing of modern foods. Omega Balance is an essential guide to understanding a significant problem in our modern food chain and will make us rethink the food we eat.

https://press.jhu.edu/books/title/12823/omega-balance

Amazon link to benefit this podcast: https://amzn.to/49JHXFo

This book won a "Best Book" award from the American Book Fest in the category "Health: Diet and Exercise".

https://www.americanbookfest.com/2023bbafullresults.html

I was introduced to Prof. Hulbert by Prof. Tom Brenna, our guest in Ep. 5: Prof. Tom Brenna, Omega-3 and Omega-6 in Human Health.

"Anthony John Hulbert (UNSW, AUS), PhD, DSc, is an internationally renowned researcher on metabolism, longevity, and nutrition. He is emeritus professor in Science, Medicine, and Health at the University of Wollongong, Australia."

https://press.jhu.edu/books/title/12823/omega-balance#book__authors

_______________________________________

Co-host Dr. Brian Kerley

https://www.seedoilrebellion.com/

https://twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?

Check out the Seedy app!

https://www.seedyapp.com/

Tucker Goodrich

Substack: https://tuckergoodrich.substack.com/

Twitter: https://twitter.com/TuckerGoodrich

Youtube: https://www.youtube.com/tuckergoodrich0

Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825

Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y

Podcast: https://sites.libsyn.com/408758

Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/

_______________________________________

In order of discussion.

Borchman, D., Stimmelmayr, R., & George, J. C. (2017). Whales, Lifespan, Phospholipids, and Cataracts. Journal of Lipid Research, 58(12), 2289–2298. https://doi.org/10.1194/jlr.M079368

Hulbert, A. J., & Else, P. L. (1999). Membranes as Possible Pacemakers of Metabolism. Journal of Theoretical Biology, 199(3), 257–274. https://doi.org/10.1006/jtbi.1999.0955

Abbott, S. K., Else, P. L., Atkins, T. A., & Hulbert, A. J. (2012). Fatty Acid Composition of Membrane Bilayers: Importance of Diet Polyunsaturated Fat Balance. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818(5), 1309–1317. https://doi.org/10.1016/j.bbamem.2012.01.011

McCollum, E. V. (1919). The Newer Knowledge of Nutrition. Macmillan Company. https://ia801302.us.archive.org/28/items/cu31924104225937/cu31924104225937.pdf

Speakman, J. R., De Jong, J. M. A., Sinha, S., Westerterp, K. R., Yamada, Y., Sagayama, H., Ainslie, P. N., Anderson, L. J., Arab, L., Bedu-Addo, K., Blanc, S., Bonomi, A. G., Bovet, P., Brage, S., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Cooper, J. A., Cooper, R., … Wong, W. W. (2023). Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure. Nature Metabolism, 5(4), 579–588. https://doi.org/10.1038/s42255-023-00782-2

Allport, S. (2010, November). One Person's Response to a High Omega-6 Diet [Magazine]. American Oil Chemists' Society. https://www.aocs.org/stay-informed/inform-magazine/featured-articles/one-persons-response-to-a-high-omega-6-diet-november-2010?SSO=True

If you have any questions about sources for things discussed please ask in the comments.

We look at a paper enlightening what causes chronic disease, in the context of a huge population of people who suffer from the most common human mutation, to the aldehyde dehydrogenase enzyme that detoxifies both alcohol and seed oil metabolites, the ALDH2*2 mutation. We discuss how this mutation is thought to affect the people who have it through the lens of the paper at hand.

This was a difficult video for me to edit, as both Matt and Brian share their experiences with the topic we are discussing in their own families.

I thought this was excellent, and hope many others can learn from it.

Here's this paper: "A Common East Asian-Specific ALDH2 Mutation Causes Obesity and Insulin Resistance: Therapeutic Effect of Reducing Toxic Aldehydes by ALDH2 Activation"

Preprint:

Chang, Y.-C., Lee, H.-L., Yang, W., Hsieh, M.-L., Liu, C.-C., Lee, T.-Y., Huang, J.-Y., Nong, J.-Y., Li, F.-A., Chuang, H.-L., Ding, Z.-Z., Su, W.-L., Chueh, L.-Y., Tsai, Y.-T., Chen, C.-H., Mochly-Rosen, D., & Chuang, L.-M. (2020). A Common East Asian-Specific ALDH2 Mutation Causes Obesity and Insulin Resistance: Therapeutic Effect of Reducing Toxic Aldehydes by ALDH2 Activation. https://doi.org/10.21203/rs.3.rs-104384/v1

Published:

Chang, Y.-C., Lee, H.-L., Yang, W., Hsieh, M.-L., Liu, C.-C., Lee, T.-Y., Huang, J.-Y., Nong, J.-Y., Li, F.-A., Chuang, H.-L., Ding, Z.-Z., Su, W.-L., Chueh, L.-Y., Tsai, Y.-T., Chen, C.-H., Mochly-Rosen, D., & Chuang, L.-M. (2023). A Common East-Asian ALDH2 Mutation Causes Metabolic Disorders and the Therapeutic Effect of ALDH2 Activators. Nature Communications, 14(1), Article 1. https://doi.org/10.1038/s41467-023-41570-6

Matt Quinn

https://twitter.com/Mqsley

https://www.mquinn.online/

TL;DR Here's what I am working on:

I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here​

I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this

I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here

In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here

I have failed at so so so many things - read about them here

https://www.mquinn.online/

_______________________________________

Dr. Brian Kerley

https://www.seedoilrebellion.com/

https://twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?

Check out the Seedy app!

https://www.seedyapp.com/

Tucker Goodrich

Substack: https://tuckergoodrich.substack.com/

Twitter: https://twitter.com/TuckerGoodrich

Youtube: https://www.youtube.com/tuckergoodrich0

Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825

Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y

Podcast: https://sites.libsyn.com/408758

Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/

_______________________________________

Previous paper:

Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis, S. M., & Rodrigues, B. (2004). Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 Pufa. American Journal of Physiology. Heart and Circulatory Physiology, 287(6), H2518-2527. https://doi.org/10.1152/ajpheart.00480.2004

Discussed in this episode:

Ep. 12 Study: What's Worse—Carbs or Seed Oils? Understanding a High-PUFA Diet—with Dr. Brian Kerley and Matt Quinn

https://tuckergoodrich.substack.com/p/ep-115-study-whats-worsecarbs-or

HNE/4-HNE in Wikipedia

https://en.wikipedia.org/wiki/4-Hydroxynonenal

Gomes, K. M. S., Campos, J. C., Bechara, L. R. G., Queliconi, B., Lima, V. M., Disatnik, M.-H., Magno, P., Chen, C.-H., Brum, P. C., Kowaltowski, A. J., Mochly-Rosen, D., & Ferreira, J. C. B. (2014). Aldehyde Dehydrogenase 2 Activation in Heart Failure Restores Mitochondrial Function and Improves Ventricular Function and Remodelling. Cardiovascular Research, 103(4), 498–508. https://doi.org/10.1093/cvr/cvu125

Brian and I are honored to be joined by the illustrious Chef Andrew Gruel. He tells us the story of how he got into cooking, how he had to learn to cook again after discovering that his academic chef training left out natural fats, and the impact using proper fats has had on his health, the health of his staff, and his customers in his latest restaurant venture.

We also have an extensive and very interesting discussion on fish, fish farming, and the health benefits of eating fish.

Web: www.chefgruel.com (It throws a security error…)

X: https://twitter.com/ChefGruel

Substack: "The Food Porn Master"! https://substack.com/@andrewgruel

Instagram: https://www.instagram.com/andrewgruel/

Calico Fish House: https://calico-restaurant.com/

"Andrew Gruel, a graduate of Johnson & Wales University, is a food entrepreneur and television personality – he is the Founder of Slapfish Restaurant Group (27 locations), the award-winning food truck turned international brick and mortar, based out of Huntington Beach, CA and currently CEO and founder of American Gravy Restaurant Group which comprises Calico Fishhouse, Big Parm Pizza, Two Birds Chicken, Butterleaf, Lolo's Tacos and 101 Burger.

"Andrew has appeared on multiple television series including his most recent role as a judge on Food Network's "Chopped Junior" with Megan Markle. He was the Host of FYI Series "Say It To My Face", as well as a judge on Food Network's "Food Truck Face Off." He has made appearances on the TODAY show, Fox News, CNN, NBC Nightly News, PBS, Cooking Channel, and has been featured in numerous publications including The Wall Street Journal, Forbes, Men's Health, Food & Wine magazine, USA Today, Entrepreneur and Nation's Restaurant News. He was named Top 25 Business Executives for Fast Casual magazine as well as featured in Nation's Restaurant News' 2017 Power List. In 2013 he was named top 40 under 40 entrepreneurs in Orange County. He and his wife Lauren Gruel were named Pandemic Heroes by Restaurant Business Magazine alongside Guy Fieri and Jose Andres. He is currently the Co-Host of The SoCal Restaurant Show on AM 830 and a regular contributor on various national news channels."

http://www.chefgruel.com/index.php/about-us.html

_______________________________________

Dr. Brian Kerley

https://www.seedoilrebellion.com/

https://twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?

Check out the Seedy app!

https://www.seedyapp.com/

Tucker Goodrich

Substack: https://tuckergoodrich.substack.com/

Twitter: https://twitter.com/TuckerGoodrich

Youtube: https://www.youtube.com/tuckergoodrich0

Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825

Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y

Podcast: https://sites.libsyn.com/408758

Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/

_______________________________________

Slapfish: https://www.slapfishrestaurant.com/

Nina Planck, "Real Food" https://amzn.to/3OhJBG8

Callico Fish House Restaurant: https://calico-restaurant.com/

Tom Brenna ep. 5: https://tuckergoodrich.substack.com/p/podcast-ep-5-prof-tom-brenna-on-omega

Cargill & McDonalds: "Removing Trans Fats from McDonald's® Famous Fries" https://www.cargill.com/history-story/en/HIGH-OLEIC.jsp

"Podcast Ep. 0: What VICE Left Out: Bitcoin and Seed Oils—Starting a Podcast" https://yelling-stop.blogspot.com/2022/04/what-vice-left-out-bitcoin-and-seed.html

We're trying something a bit different today. Dr. Brian Kerley and I have found a victim, Matt Quinn. Matt's a smart guy but he's not as immersed in these topics as we are, and so he's going to play our straight man, the every-day guy who can hopefully come to easily-digested conclusions about the papers we discuss.

In our inaugural episode we discuss "Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 PUFA".

Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis, S. M., & Rodrigues, B. (2004). Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 Pufa. American Journal of Physiology. Heart and Circulatory Physiology, 287(6), H2518-2527. https://doi.org/10.1152/ajpheart.00480.2004

Matt Quinn

https://twitter.com/Mqsley

https://www.mquinn.online/

TL;DR Here's what I am working on:

I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here​

I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this

I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here

In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here

I have failed at so so so many things - read about them here

https://www.mquinn.online/

_______________________________________

Dr. Brian Kerley

https://www.seedoilrebellion.com/

https://twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?

Check out the Seedy app!

https://www.seedyapp.com/

Tucker Goodrich

Substack: https://tuckergoodrich.substack.com/

Twitter: https://twitter.com/TuckerGoodrich

Youtube: https://www.youtube.com/tuckergoodrich0

Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825

Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y

Podcast: https://sites.libsyn.com/408758

Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/

_______________________________________

Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis, S. M., & Rodrigues, B. (2004). Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 Pufa. American Journal of Physiology. Heart and Circulatory Physiology, 287(6), H2518-2527. https://doi.org/10.1152/ajpheart.00480.2004

I discussed this in a blog post. I won't be doing this for most of the studies we discuss, but I figured it was handy to start with one where I had already done some work!

What's Worse—Carbs or Seed Oils? Understanding a High-PUFA Diet.

tl;dr: The one study I'm aware of that shows conclusively that excess glucose acts as an accelerant for excess omega-6 fat, but it not nearly so harmful without the omega-6, in vivo.

https://tuckergoodrich.substack.com/p/whats-worsecarbs-or-seed-oils-understanding

We interview Paul Saladino MD about his intellectual journey from being a raw vegan with rotting teeth as a physician's assistant, through becoming the "Carnivore MD", to where he is today. We discuss the training a physician receives in medical school about nutrition, and how he filled that gap with his own experience and research. And how it impacted his health and his ideas about being a physician.

Josh Durham, my personal physician, joins me as co-host today to recount his personal health journey as well and how it changed his practice. (He recently quit his job at a large hospital to go independent!)

Paul Saladino, MD:

https://www.paulsaladinomd.co/

Dr. Saladino's "The Carnivore Code" book:

https://amzn.to/47OCjAt

Biography of Paul Saladino:

I'm a double board certified MD, host of the Fundamental Health podcast, and author of The Carnivore Code and The Carnivore Code Cookbook.

I believe in questioning our assumptions about health and nutrition, which makes me controversial in modern medicine. I'm much more interested in optimal health than in dogmatic adherence to a mainstream narrative.

I graduated from medical school at the University of Arizona in Tucson, and completed my residency at the University of Washington in Seattle. After residency, I attained a board certification as a Physician Nutrition Specialist.

Throughout my medical training, I came to one very saddening conclusion: our Western medical system isn't helping people lead richer lives.

Western medicine fails to treat the root cause of chronic illness, and doctors are only taught to treat symptoms with medications, rather than trying to understand the roots of illness.

I firmly believe that nutritional choices lie at the ROOT of so many chronic illnesses that western medicine deems irreversible.

And I also believe that most chronic illnesses are preventable AND reversible.

https://www.paulsaladinomd.co/about

_______________________________________

Co-host Joshua Durham, DO:

https://www.drdurham.org/

Looking to fix your diet by getting rid of seed oils?

Check out the Seedy app!

https://www.seedyapp.com/

Tucker Goodrich

Substack: https://tuckergoodrich.substack.com/

Twitter: https://twitter.com/TuckerGoodrich

Youtube: https://www.youtube.com/tuckergoodrich0

Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825

Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y

Podcast: https://sites.libsyn.com/408758

Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/

_______________________________________

Show Notes

Jordan Petersen on Joe Rogan discussing carnivore diet:

https://www.youtube.com/watch?v=HLF29w6YqXs

Farley Mowat "People of the Deer" book:

https://amzn.to/3Uc42bh

Amgen: "8 Things to Know About Lipoprotein(a)"

https://www.amgen.com/stories/2023/02/8-things-to-know-about-lipoproteina

"AMGEN ANNOUNCES POSITIVE TOPLINE PHASE 2 DATA FOR INVESTIGATIONAL OLPASIRAN IN ADULTS WITH ELEVATED LIPOPROTEIN(a)":

https://www.amgen.com/newsroom/press-releases/2022/05/amgen-announces-positive-topline-phase-2-data-for-investigational-olpasiran-in-adults-with-elevated-lipoproteina

"Seed oils are BS" t-shirt: https://www.bunkerbranding.com/collections/paul-saladino-md-shirts/products/seed-oils-are-bs?variant=42776441782403

If you have any questions about sources for things discussed please ask in the comments.

Dr. Kerley and I are joined by Dalton Graham, a student who found himself in a liver pathology lab at Tulane. He had the interesting idea to test if a high-linoleic acid diet could be shown to produce fatty liver disease at the same time it was causing obesity. The scientists in the lab required a little convincing that this was a worthy experiment, but one day he arrived to find all the materials he need waiting for him. Be careful what you wish for! Find out how it turned out.

Graham, D. S., Liu, G., Arasteh, A., Yin, X.-M., & Yan, S. (2023). Ability of High Fat Diet to Induce Liver Pathology Correlates with the Level of Linoleic Acid and Vitamin E in the Diet. PLOS ONE, 18(6), e0286726. https://doi.org/10.1371/journal.pone.0286726

Biography: • Dalton is currently a PhD student at University of Florida, studying Biochemistry with a focus on metabolism. When he wrote the paper we are discussing, he was an undergrad, and then grad student at Tulane University, studying Biochemical Engineering and Pathology. _______________________________________ Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/

Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Podcast: https://sites.libsyn.com/408758 Twitter: https://twitter.com/TuckerGoodrich _______________________________________ Show Notes "Alvheim papers out of the NIH" Alvheim, A. R., Malde, M. K., Osei‐Hyiaman, D., Hong, Y. H., Pawlosky, R. J., Madsen, L., Kristiansen, K., Frøyland, L., & Hibbeln, J. R. (2012). Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity. Obesity, 20(10), 1984–1994. https://doi.org/10.1038/oby.2012.38 Alvheim, A. R. (2012). Dietary linoleic acid induces obesity through excessive endocannabinoid activity [Doctor of Philosophy, The University of Bergen]. https://bora.uib.no/bora-xmlui/handle/1956/5962 NAFLD discovered in 1980: Ludwig, J., Viggiano, T. R., McGill, D. B., & Oh, B. J. (1980). Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clinic Proceedings, 55(7), 434–438. Liver transplants and NAFLD: Lindenmeyer, C. C., & McCullough, A. J. (2018). The Natural History of Nonalcoholic Fatty Liver Disease—An Evolving View. Clinics in Liver Disease, 22(1), 11. https://doi.org/10.1016/j.cld.2017.08.003 Linoleic acid and breast milk: Goodrich, T. D. (2022, September 1). Podcast Ep. 5: Prof. Tom Brenna on Omega-3 and Omega-6 in Human Health—with Dr Brian Kerley [Blog]. Yelling Stop. http://yelling-stop.blogspot.com/2022/09/podcast-ep-5-prof-tom-brenna-on-omega-3.html Gornoski, D. (2021, June 15). Bruce German on How Human Milk Does the Body Good (Jun 15 2021) [Mp3]. https://podcastaddict.com/episode/124448388 Speakman paper on lethargy: Speakman, J. R., De Jong, J. M. A., Sinha, S., Westerterp, K. R., Yamada, Y., Sagayama, H., Ainslie, P. N., Anderson, L. J., Arab, L., Bedu-Addo, K., Blanc, S., Bonomi, A. G., Bovet, P., Brage, S., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Cooper, J. A., Cooper, R., … Wong, W. W. (2023). Total Daily Energy Expenditure Has Declined Over the Past Three Decades Due to Declining Basal Expenditure, Not Reduced Activity Expenditure. Nature Metabolism, 5(4), 579–588. https://doi.org/10.1038/s42255-023-00782-2 Vitamin E: Masterjohn, C. (2017, June 24). 032: Is Coconut Oil Killing Us? [Substack newsletter]. Harnessing the Power of Nutrients. https://chrismasterjohnphd.substack.com/p/041-is-coconut-oil-killing-us Raghavamenon, A., Garelnabi, M., Babu, S., Aldrich, A., Litvinov, D., & Parthasarathy, S. (2009). α-Tocopherol Is Ineffective in Preventing the Decomposition of Preformed Lipid Peroxides and May Promote the Accumulation of Toxic Aldehydes: A Potential Explanation for the Failure of Antioxidants to Affect Human Atherosclerosis. Antioxidants & Redox Signaling, 11(6), 1237–1248. https://doi.org/10.1089/ars.2008.2248 NAFLD and Fructose: Vos, M. B., Weber, M. B., Welsh, J., Khatoon, F., Jones, D. P., Whitington, P. F., & McClain, C. J. (2009). Fructose and Oxidized LDL in Pediatric Nonalcoholic Fatty Liver Disease: A Pilot Study. Archives of Pediatrics & Adolescent Medicine, 163(7), 674–675. https://doi.org/10.1001/archpediatrics.2009.93 Cardiolipin: Goodrich, T. (2016, February 5). The Cause of Metabolic Syndrome: Excess Omega-6 Fats (Linoleic Acid) in Your Mitochondria. Yelling Stop. http://yelling-stop.blogspot.com/2016/02/the-cause-of-metabolic-syndrome-excess.html

Quotable: "I made a presentation about the role of excess linoleic acid in liver diseases. …I sat down and I pitched it… to the individuals in that lab. At first they didn't really get it… I remember when I first finished laying out the mechanisms and why this is needed. Typically at the end of a presentation there are a bunch of questions, and there was just… silence. "They'd never been presented with this idea that lipid peroxidation (or oxidative stress) manifests itself mainly due to this dietary factor—that no one seems to realize because it's so ubiquitous." "These animals that are eating the higher linoleic acid they appear physical slower." "The females that were fed the high linoleic acid, they actually lost a lot of their fur [while under stress]. We couldn't continue the experiment with them." "I don't think they understood the importance of [linoleic acid] in the real world."

Dave Feldman and I discuss the what causes heart disease, specifically focusing on the consensus view and how it differs from what the science actually shows.

Youtube: https://youtu.be/amwNvHHmy4o

Rumble:

X:

Podcast:

Topics:

Basic theory of CVD causation:

· High ApoB/LDL/Cholesterol

· Gradient causes penetration of arterial wall

· Cholesterol/lipid oxidation in wall

· Progression through stages of atherosclerosis

· Blockage/rupture of plaque

· Ischemia of blood to heart

· Death/morbidity via MI

Electro-negative LDL

Aggregated LDL

TG-rich Lipoproteins

Risk and factor models

FH mortality—implications for causality

ApoB48

Albumin

Vasa vasorum

'Atherosclerosis' in veins

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Dave Feldman

Biography:

"I'm a senior software engineer and entrepreneur.

"I began a Low Carb, High Fat diet in April 2015 and have since learned everything I could about it with special emphasis on cholesterol given my lipid numbers spiked substantially after going on the diet. As an engineer, I spotted a pattern in the lipid system that's very similar to distributed objects in networks.

"I've since learned quite a bit on the subject both through research and experimentation which has revealed some very powerful data. With this new general theory, I've shifted around my cholesterol substantially without any drugs or special supplements of any kind.

From: https://cholesterolcode.com/about/

Blog: https://cholesterolcode.com/

Twitter: https://twitter.com/realDaveFeldman

Citizen Science Foundation:

Site: https://citizensciencefoundation.org/

Twitter: https://twitter.com/realCSF

DONATE: https://citizensciencefoundation.org/donate/

Own Your Labs: https://ownyourlabs.com/

Tucker Goodrich

Blog: http://yelling-stop.blogspot.com/

Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg

Podcast: https://sites.libsyn.com/408758

Twitter: https://twitter.com/TuckerGoodrich

Looking to fix your diet by getting rid of seed oils?

Check out the Seedy app!

https://www.seedyapp.com/

_______________________________________

Show Notes

Notes

See the canine LMHR study:

Kronfeld, D. S., Hammel, E. P., Ramberg, C. F., & Dunlap, H. L. (1977). Hematological and metabolic responses to training in racing sled dogs fed diets containing medium, low, or zero carbohydrate. The American Journal of Clinical Nutrition, 30(3), 419–430. https://doi.org/10.1093/ajcn/30.3.419

Lipid-Energy Model

Norwitz, N. G., Feldman, D., Soto-Mota, A., Kalayjian, T., & Ludwig, D. S. (2022). Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a "Lean Mass Hyper-Responder" Phenotype. Current Developments in Nutrition, 6(1), nzab144. https://doi.org/10.1093/cdn/nzab144

Norwitz, N. G., Soto-Mota, A., Kaplan, B., Ludwig, D. S., Budoff, M., Kontush, A., & Feldman, D. (2022). The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets. Metabolites, 12(5), Article 5. https://doi.org/10.3390/metabo12050460

PubMed for Dave's other papers:

https://pubmed.ncbi.nlm.nih.gov/?term=norwitz+feldman&sort=pubdate

Thoracic duct image:

Rosenblum, H., Kapur, N. K., Abraham, W. T., Udelson, J., Itkin, M., Uriel, N., Voors, A. A., & Burkhoff, D. (2020). Conceptual Considerations for Device-Based Therapy in Acute Decompensated Heart Failure: DRI 2 P 2 S. Circulation: Heart Failure, 13(4), e006731. https://doi.org/10.1161/CIRCHEARTFAILURE.119.006731

Lipoprotein lipase effect on heart:

Khan, R. S., Lin, Y., Hu, Y., Son, N.-H., Bharadwaj, K. G., Palacios, C., Chokshi, A., Ji, R., Yu, S., Homma, S., Schulze, P. C., Tian, R., & Goldberg, I. J. (2013). Rescue of Heart Lipoprotein Lipase-Knockout Mice Confirms a Role for Triglyceride in Optimal Heart Metabolism and Function. American Journal of Physiology-Endocrinology and Metabolism, 305(11), E1339–E1347. https://doi.org/10.1152/ajpendo.00349.2013

EAS Consensus:

Ference, B. A. et. al. (2017). Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. European Heart Journal, 38(32), 2459–2472. https://doi.org/10.1093/eurheartj/ehx144

Borén, J. et. al. (2020). Low-density lipoproteins cause atherosclerotic cardiovascular disease: Pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel. European Heart Journal, 41(24), 2313–2330. https://doi.org/10.1093/eurheartj/ehz962

FH epidemiology:

Sijbrands, E. J. G. et. al. (2001). Mortality over two centuries in large pedigree with familial hypercholesterolaemia: Family tree mortality study. BMJ, 322(7293), 1019–1023. https://doi.org/10.1136/bmj.322.7293.1019

Is CVD Genetic?

Lee, K. T., Nail, R., Sherman, L. A., Milano, M., Lee, K. T., Deden, C., Imai, H., Goodale, F., Nam, S. C., Lee, K. T., Goodale, F., Scott, R. F., Snell, E. S., Lee, K. T., Daoud, A. S., Jarmolych, J., Jakovic, L., & Florentin, R. (1964). Geographic Pathology of Myocardial Infarction: Part I. Myocardial infarction in orientals and whites in the United States; Part II. Myocardial infarction in orientals in Korea and Japan; Part III. Myocardial infarction in Africans in Africa and negroes and whites in the United States; Part IV. Measurement of amount of coronary arteriosclerosis in Africans, Koreans, Japanese and New Yorkers. The American Journal of Cardiology, 13(1), 30–40. https://doi.org/10.1016/0002-9149(64)90219-X

Presentation on Rancidity in Seed Oils

AOCS American Oil Chemists' Society (Director). (2021, April 1). Why Does Lipid Oxidation in Foods Continue to be Such a Challenge? [Mp4]. https://www.youtube.com/watch?v=B_U_9vvpDWo

Mercodia OxLDL Assay

Feldman, D. (2019, May 11). The Oxidized LDL Experiment [Informational]. Cholesterol Code. https://cholesterolcode.com/the-oxidized-ldl-experiment/

OxPL/ApoB test:

"Oxidized Phospholipids on apoB (OxPL-apoB)"

https://bostonheartdiagnostics.com/test/oxpl-apob-c-2/

Q's from X ( https://X.com ):

1. Eric Rodgers @LowCarbEyeDoc

ApoB48

2. Shashi Iyengar | Accredited Metabolic Health Coach @shashiiyengar

Touch up on palm oil Unprocessed and Refined deodorized one..

3. The Real Dr. Steven Horvitz @IMWHorvitz The difference between natural omega6 fats vs industrial processed omega6 fats.

4. MEATrition.com 🥩 @MEATritionCom

How does adipose %LA track with blood lipids?

5. MEATrition.com 🥩 @MEATritionCom

Specific ownyourlabs values to check for before and after removing seed oils from diet. What's hypothesis?

6. TheFa(c)tHunter @DimitriRadoux

This might be an interesting one, the relationship of RDW and polyunsaturated fats 😉

7. joe @vintage_worlds

A few words on the ideal level of Linoleic acid as measured in rbc? Anyone set out to avoid seed oil while measuring their linoleic acid levels who have shown dramatic reductions by avoiding?

8. Michael J @astro_toaster

Fish oil and effects of supplementation on cholesterol? Supplements vs eating actual fish? 🤔

9. Luigi @Bac2us

Insulin resistance / consequences

Discussion with Paul Hart, formerly of Unilever and currently a consultant to the processed food industry, on the pros and cons are of processed foods, and what the food industry is hoping to accomplish.

Medicine needs to be fixed:

"The New Crisis of Increasing All-Cause Mortality in US Children and Adolescents"

· https://jamanetwork.com/journals/jama/article-abstract/2802602

Dr. Tro Kalayjian

Dr. Tro's Medical Weight Loss

· https://doctortro.com/

Research:

· https://scholar.google.com/citations?user=ByYma7sAAAAJ

Twitter:

· https://twitter.com/DoctorTro

Dr. Brian Lenzkes

Metabolic Health:

· San Diego: https://sandiegometabolichealth.com/

· Arizona: https://arizonametabolichealth.com/brian-lenzkes-md/

Twitter:

· https://twitter.com/BrianLenzkes

Dr. Joshua Durham

Twitter:

· https://twitter.com/JoshuaD81699641

Dr. Eric Westman

· https://ericwestmanmd.com/

New Atkins for a New You: The Ultimate Diet for Shedding Weight and Feeling Great by Eric C. Westman, Stephen D. Phinney, Jeff S. Volek

· https://amzn.to/3qd9fzy (this link benefits the podcast!)

Philip Ovadia

· https://ovadiahearthealth.com/

Alessio Fassano

· https://nutrition.hms.harvard.edu/people/alessio-fasano

Research:

· https://scholar.google.com/citations?user=8IxzUn0AAAAJ&hl=en&oi=ao

Whole30

· https://whole30.com/

Virta

· https://www.virtahealth.com/

Dr. Tro app

· https://apps.apple.com/us/app/doctor-tro/id1588693888

Lenzkes & Kalayjian's podcast: Low-Carb MD Podcast

· https://www.lowcarbmd.com/

_______________________________________

Co-host Dr. Brian Kerley

https://www.seedoilrebellion.com/

https://twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?

Check out the Seedy app!

https://www.seedyapp.com/

Tucker Goodrich

Blog: http://yelling-stop.blogspot.com/

Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg

Podcast: https://sites.libsyn.com/408758

Twitter: https://twitter.com/TuckerGoodrich

_______________________________________