Tucker Goodrich: Debugging Life

Dr. Durham is a Family Physician in Boise, Idaho; and is Tucker's doctor. We discuss how his practice has changed since he figured out how to solve his own chronic health problems, how this has changed his practice, some successes, and more. Joshua Durham, DO • https://www.saintalphonsus.org/provider/joshua-durham Blog comment: Dr. Durham: "If you need a family Dr. here in Boise hit me up. I went from 235lbs to keto to carnivore and then finally came across your info. Now at 195 I feel comfortable knowing what I can and can't have and why I was so sick. Felt great on carnivore but can't live that way forever. Thank you for your work." • http://yelling-stop.blogspot.com/2021/04/experts-do-as-we-say-not-as-we-do.html?showComment=1620609617154#c416429453974276542 "Doctor of Osteopathy vs. Medical Doctor- What are the Differences?" • https://hecec.human.cornell.edu/2016/02/12/doctor-of-osteopathy-vs-medical-doctor-what-are-the-differences/ Dr. Eric Westman • https://ericwestmanmd.com/ New Atkins for a New You: The Ultimate Diet for Shedding Weight and Feeling Great by Eric C. Westman, Stephen D. Phinney, Jeff S. Volek • https://amzn.to/3qd9fzy (this link benefits the podcast!) Dr. Durham: "Good fat/bad fat" I wrote a post about this: "Good Keto vs. Bad Keto" • http://yelling-stop.blogspot.com/2021/09/good-keto-vs-bad-keto.html Dr. Durham: "Then I saw your interview with Paul Saladino…" • "How Seed Oils Destroy Your Mitochondria and Lead To Chronic Disease, with Tucker Goodrich" https://carnivoremd.com/how-seed-oils-destroy-your-mitochondria-and-lead-to-chronic-disease-with-tucker-goodrich/ "…and then I watched Brad Marshall…" • Brad's blog is here: https://fireinabottle.net/ Drs. Kerley and Durham compare "elevator pitches" to patients. Dr. Durham: "I needed 4 pills based on the guidelines, and I was 38 years old." Tucker: "Lean-Mass Hyper Responder": Norwitz, N. G., Soto-Mota, A., Kaplan, B., Ludwig, D. S., Budoff, M., Kontush, A., & Feldman, D. (2022). The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets. Metabolites, 12(5), 460. https://doi.org/10.3390/metabo12050460 Dr. Durham: 40:02 "American College of Cardiology article…" Astrup, A., Magkos, F., Bier, D. M., Brenna, J. T., de Oliveira Otto, M. C., Hill, J. O., King, J. C., Mente, A., Ordovas, J. M., Volek, J. S., Yusuf, S., & Krauss, R. M. (2020). Saturated Fats and Health: A Reassessment and Proposal for Food-based Recommendations: JACC State-of -the-Art Review. Journal of the American College of Cardiology, 76(7), 844–857. https://doi.org/10.1016/j.jacc.2020.05.077 See Episode 5, in which we interview Tom Brenna, one of the co-authors of that article: https://www.youtube.com/watch?v=rrQ8q_ctGUQ Tucker: "The AGEs, same thing—Chris Masterjohn did a great post years ago looking into it: Masterjohn, C. (2011, October 7). Where Do Most AGEs Come From? O Glycation, How Thy Name Hast Deceived Me! | [Blog]. Chris Masterjohn, PhD. https://chrismasterjohnphd.com/blog/2011/10/07/where-do-most-ages-come-from-o Tucker: "Polyunsaturated fats are about 10x as effective in producing advanced glycation end products [than glucose]…" Fu, M.-X., Requena, J. R., Jenkins, A. J., Lyons, T. J., Baynes, J. W., & Thorpe, S. R. (1996). The Advanced Glycation End Product, N-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions. Journal of Biological Chemistry, 271(17), 9982–9986. https://doi.org/10.1074/jbc.271.17.9982 Tucker: Lp(a): • Hazard ratio 16.8: Tsimikas, S., Brilakis, E. S., Miller, E. R., McConnell, J. P., Lennon, R. J., Kornman, K. S., Witztum, J. L., & Berger, P. B. (2005). Oxidized Phospholipids, Lp(a) Lipoprotein, and Coronary Artery Disease. New England Journal of Medicine, 353(1), 46–57. https://doi.org/10.1056/NEJMoa043175 • Hazard ratio 1 in Africa: Paré, G., Çaku, A., McQueen, M., Anand, S. S., Enas, E., Clarke, R., Boffa, M. B., Koschinsky, M., Wang, X., Yusuf, S., & null, null. (2019). Lipoprotein(a) Levels and the Risk of Myocardial Infarction Among 7 Ethnic Groups. Circulation, 139(12), 1472–1482. https://doi.org/10.1161/CIRCULATIONAHA.118.034311 • 2 sure-fire ways to raise Lp(a): 1. Statins: Yeang, C., Hung, M.-Y., Byun, Y.-S., Clopton, P., Yang, X., Witztum, J. L., & Tsimikas, S. (2016). Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a). Journal of Clinical Lipidology, 10(3), 594–603. https://doi.org/10.1016/j.jacl.2016.01.005 2. Healthy diet: Navab Mohamad, Reddy Srinivasa T., Van Lenten Brian J., & Fogelman Alan M. (2004). Apparent Paradox of Low-Fat "Healthy" Diets Increasing Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a). Arteriosclerosis, Thrombosis, and Vascular Biology, 24(3), 392–393. https://doi.org/10.1161/01.ATV.0000118014.49565.fc • Pork and LDL: Stewart, J. W., Kaplan, M. L., & Beitz, D. C. (2001). Pork with a high content of polyunsaturated fatty acids lowers LDL cholesterol in women. The American Journal of Clinical Nutrition, 74(2), 179–187. https://doi.org/10.1093/ajcn/74.2.179 Treating Lp(a)/OxLDL with antibodies: https://www.oxitopepharma.com/approach Dr. Kerley: Robb Wolf interview: https://www.youtube.com/watch?v=Lku8kJdHOqY Wooden breast in chickens: Soglia, F., Mudalal, S., Babini, E., Di Nunzio, M., Mazzoni, M., Sirri, F., Cavani, C., & Petracci, M. (2016). Histology, composition, and quality traits of chicken Pectoralis major muscle affected by wooden breast abnormality. Poultry Science, 95(3), 651–659. https://doi.org/10.3382/ps/pev353 "Dr. Mark Cucuzzella – A Doctor's Perspective On Treating Diabetes" https://robbwolf.com/2016/07/26/episode-329-dr-mark-cucuzzella-a-doctors-perspective-on-treating-diabetes/

Human results of a low-linoleic diet with adequate omega-3 on neurodevelopment.

The WHO change their guidelines.

How to protect against blindness.

Why the Dietary Guidelines can't get it right, and where they do.

Fish vs fish oil for omega-3 DHA benefits.

Fish consumption and mercury, is it a problem?

Farmed vs. wild-caught fish.

On the essentiality of linoleic acid.

Linoleic acid impairs fertility

Biography:

Tom Brenna, Ph.D., Professor, Department of Pediatrics, Dell Medical School, UT Austin;

• https://dellmed.utexas.edu/directory/tom-brenna

"Tom Brenna is a professor of pediatrics at Dell Medical School. He moved to Austin after 28 years as a professor of human nutrition, chemistry, chemical biology and food science at Cornell University in Ithaca, New York. His group's basic research into the chemical, biochemical, metabolic, genetic and ecological aspects of fatty acids have had a decisive influence on modern knowledge of these key nutrients.

"Brenna's research couples nutrition and chemistry in a broadly interdisciplinary program. His research group has been funded by institutes and centers at the National Institutes of Health (National Institute of General Medical Sciences, National Eye Institute, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Center for Complementary and Integrative Health) since 1992. Most of the work of the Brenna Lab is translational, tying basic research to biomedicine and human nutrition…."

Professor Emeritus, Division of Nutritional Sciences, Cornell University.

• https://www.human.cornell.edu/people/jtb4

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Co-host Dr. Brian Kerley

https://www.seedoilrebellion.com/

https://twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?

Check out the Seedy app!

https://www.seedyapp.com/

Tucker Goodrich

Blog: http://yelling-stop.blogspot.com/

Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg

Podcast: https://sites.libsyn.com/408758

Twitter: https://twitter.com/TuckerGoodrich

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Show Notes

Nina Teicholz' organization is The Nutrition Coalition.

• https://www.nutritioncoalition.us/

Q: "What are you working on right now? What the most recent and interesting thing that you have published?"

1. RCT of low-linoleic therapeutic foods:
   • Stephenson, K., Callaghan-Gillespie, M., Maleta, K., Nkhoma, M., George, M., Park, H. G., Lee, R., Humpheries-Cuff, I., Lacombe, R. J. S., Wegner, D. R., Canfield, R. L., Brenna, J. T., & Manary, M. J. (2021). Low linoleic acid foods with added DHA given to Malawian children with severe acute malnutrition improve cognition: A randomized, triple blinded, controlled clinical trial. The American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqab363
   • Hsieh, J.-C., Liu, L., Zeilani, M., Ickes, S., Trehan, I., Maleta, K., Craig, C., Thakwalakwa, C., Singh, L., Brenna, J. T., & Manary, M. J. (2015). High-Oleic Ready-to-Use Therapeutic Food Maintains Docosahexaenoic Acid Status in Severe Malnutrition. Journal of Pediatric Gastroenterology and Nutrition, 61(1), 138–143. https://doi.org/10.1097/MPG.0000000000000741
   • Codex Alimentarius: New Ready-to-Use Therapeutic Foods guidelines. https://www.fao.org/fao-who-codexalimentarius/news-and-events/news-details/en/c/1458680/
   • "WHO summary on the available evidence for the essential fatty acid profiles in ready-to-use therapeutic foods for treating children with severe wasting" https://www.fao.org/fao-who-codexalimentarius/sh-proxy/en/?lnk=1&url=https%253A%252F%252Fworkspace.fao.org%252Fsites%252Fcodex%252FMeetings%252FCX-720-42%252FLinks%252FWHO_summary_on_EFA_in_RUTF.pdf
   • Saturated fat and cardiovascular disease: "Saturated Fats and Health: A Reassessment and Proposal for Food-based Recommendations: JACC State-of -the-Art Review": * http://www.sciencedirect.com/science/article/pii/S0735109720356874
   • "Though no human randomized controlled trials on minimal omega-3 requirements in pregnancy and lactation have been conducted, the weight of animal evidence compellingly shows that randomizing pregnant or lactating humans to diets that include high linoleate oils as the sole source of fat would be frankly unethical because they would result in suboptimal child development." Brenna, J. T. (2011). Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. Maternal & Child Nutrition, 7 Suppl 2, 59–79. https://doi.org/10.1111/j.1740-8709.2011.00301.x
   • "Put another way, only 2 ways are known to increase circulating DHA status in humans: 1) consume (preformed) DHA, or 2) lower dietary LA." Kothapalli, K. S. D., Park, H. G., & Brenna, J. T. (2020). Polyunsaturated fatty acid biosynthesis pathway and genetics. Implications for interindividual variability in prothrombotic, inflammatory conditions such as COVID-19. Prostaglandins, Leukotrienes and Essential Fatty Acids, 162, 102183. https://doi.org/10.1016/j.plefa.2020.102183
   • "We generated a paper showing that that is the case, back in 2007 or 2009. I think it's this, since the last sentence is "Present evidence indicates that n-3 LCPUFA status can be improved by increasing their intake or by decreasing LA intake, and a combination of the two is likely to be most effective.": Brenna, J. T., Salem, N., Sinclair, A. J., & Cunnane, S. C. (2009). α-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins, Leukotrienes and Essential Fatty Acids, 80(2), 85–91. https://doi.org/10.1016/j.plefa.2009.01.004
   • "That's why the story of just having a ratio between omega-6 and omega-3 is just not a way to think about this as a general concept. If you increase [non-DHA] omega-3 you don't get more DHA, but if you decrease omega-6 linoleic, you do get more.
2. "Would you like an update on that? We found a third way…" Klatt, K. C., McDougall, M. Q., Malysheva, O. V., Taesuwan, S., Loinard-González, A. (Alex) P., Nevins, J. E. H., Beckman, K., Bhawal, R., Anderson, E., Zhang, S., Bender, E., Jackson, K. H., King, D. J., Dyer, R. A., Devapatla, S., Vidavalur, R., Brenna, J. T., & Caudill, M. A. (2022). Prenatal choline supplementation improves biomarkers of maternal docosahexaenoic acid status among pregnant participants consuming supplemental DHA: A randomized controlled trial. The American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqac147
   • "we had done studies in the 1990s, and followed up after the turn of the millennium, that showed that just with oils you get a better targeting of DHA and another n-3 that's important, arachidonic acid [AA, I think he is mis-speaking here, as AA is n-6, not n-3] to the brain if they come in as a phospholipid and not a tryglyceride. Cunnane, S. C. (2002). Arachidonate metabolism in neonates. Pediatric Research, 51(3), 263–264. https://doi.org/10.1203/00006450-200203000-00001 Wijendran, V., Huang, M.-C., Diau, G.-Y., Boehm, G., Nathanielsz, P. W., & Brenna, J. T. (2002). Efficacy of dietary arachidonic acid provided as triglyceride or phospholipid as substrates for brain arachidonic acid accretion in baboon neonates. Pediatric Research, 51(3), 265–272. https://doi.org/10.1203/00006450-200203000-00002 Zhang, Q., Wu, W. X., Nathanielsz, P. W., & Brenna, J. T. (1995). Distribution of arachidonic, eicosapentaenoic, docosahexaenoic and related fatty acids in ovine endometrial phospholipids in late gestation and labor. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 53(3), 201–209. https://doi.org/10.1016/0952-3278(95)90117-5
3. "This one is a much more technological. I will explain it, and I will also say that I have a bit of a business interest… in the company that's doing this…." "DHA and all PUFAs are well known to be susceptible to oxidation…" Liu, Y., Bell, B. A., Song, Y., Zhang, K., Anderson, B., Axelsen, P. H., Bohannan, W., Agbaga, M.-P., Park, H. G., James, G., Brenna, J. T., Schmidt, K., Dunaief, J. L., & Shchepinov, M. S. (2022). Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy-like retinal degeneration in a mouse model with iron overload. Aging Cell, 21(4), e13579. https://doi.org/10.1111/acel.13579

Q: "Why is consuming more linoleic acid reducing DHA in the body?"

A: Mohrhauer, H., & Holman, R. T. (1963). The effect of dose level of essential fatty acids upon fatty acid composition of the rat liver *. Journal of Lipid Research, 4(2), 151–159. https://doi.org/10.1016/S0022-2275(20)40341-4

Paper that introduced omega nomenclature for fats: Holman, R. T. (1964). Nutritional And Metabolic Interrelationships Between Fatty Acids. Federation Proceedings, 23, 1062–1067.

Zhang, J. Y., Kothapalli, K. S. D., & Brenna, J. T. (2016). Desaturase and elongase limiting endogenous long chain polyunsaturated fatty acid biosynthesis. Current Opinion in Clinical Nutrition and Metabolic Care, 19(2), 103–110. https://doi.org/10.1097/MCO.0000000000000254

Q: "Interesting. But you would think based on that… Let's touch on your experience with the dietary guidelines a little bit, you would think that that would be reflected in some of the recommendations on how we eat."

A: Astrup, A., Teicholz, N., Magkos, F., Bier, D. M., Brenna, J. T., King, J. C., Mente, A., Ordovas, J. M., Volek, J. S., Yusuf, S., & Krauss, R. M. (2021). Dietary Saturated Fats and Health: Are the U.S. Guidelines Evidence-Based? Nutrients, 13(10), 3305. https://doi.org/10.3390/nu13103305

McGovern Report 1977: Needs, U. S. C. S. S. C. on N. and H., & Mottern, N. (1977). Dietary Goals for the United States. U.S. Government Printing Office. https://www.google.com/books/edition/Dietary_Goals_for_the_United_States/kNH4BNDQETQC?hl=en

Sandy, D. B. (1989). The Production and Use of Vegetable Oils in Ptolemaic Egypt. Scholars Press. https://www.google.com/books/edition/The_Production_and_Use_of_Vegetable_Oils/mg1tQgAACAAJ?hl=en

NEED TO SEND TO BRENNA

Menayang, A. (2017, April 30). Mars pledges to use 100% high-oleic peanuts in M&Ms, Munch Bar, by end of 2017. Foodnavigator-Usa.Com. https://www.foodnavigator-usa.com/Article/2017/05/01/Mars-and-peanut-industry-to-use-only-high-oleic-peanuts-in-products

O'Keefe, S. F., Wiley, V. A., & Knauft, D. A. (1993). Comparison of oxidative stability of high- and normal-oleic peanut oils. Journal of the American Oil Chemists' Society, 70(5), 489–492. https://doi.org/10.1007/BF02542581

Q: "What's a plausible dream study you would like to perform?"

Gornoski, D. (2021, October 3). Professor Ameer Taha on Lipid Oxidation, Linoleic Acid, OXLAMS (No. 2021-10–03) [Mp3]. https://aneighborschoice.com/professor-ameer-taha-on-lipid-oxidation-linoleic-acid-oxlams/

Ramsden's headache studies:

Mann, J. D., Faurot, K. R., MacIntosh, B., Palsson, O. S., Suchindran, C. M., Gaylord, S. A., Lynch, C., Johnston, A., Maiden, K., Barrow, D. A., Hibbeln, J. R., & Ramsden, C. E. (2018). A sixteen-week three-armed, randomized, controlled trial investigating clinical and biochemical effects of targeted alterations in dietary linoleic acid and n-3 EPA+DHA in adults with episodic migraine: Study protocol. Prostaglandins, Leukotrienes and Essential Fatty Acids, 128, 41–52. https://doi.org/10.1016/j.plefa.2017.11.002

Ramsden, C. E., Domenichiello, A. F., Yuan, Z.-X., Sapio, M. R., Keyes, G. S., Mishra, S. K., Gross, J. R., Majchrzak-Hong, S., Zamora, D., Horowitz, M. S., Davis, J. M., Sorokin, A. V., Dey, A., LaPaglia, D. M., Wheeler, J. J., Vasko, M. R., Mehta, N. N., Mannes, A. J., & Iadarola, M. J. (2017). A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch. Science Signaling, 10(493). https://doi.org/10.1126/scisignal.aal5241

Ramsden, C. E., Faurot, K. R., Zamora, D., Suchindran, C. M., MacIntosh, B. A., Gaylord, S., Ringel, A., Hibbeln, J. R., Feldstein, A. E., Mori, T. A., Barden, A., Lynch, C., Coble, R., Mas, E., Palsson, O., Barrow, D. A., & Mann, D. J. (2013). Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: A randomized trial. Pain, 154(11), 2441–2451. https://doi.org/10.1016/j.pain.2013.07.028

Ramsden, C. E., Ringel, A., Feldstein, A. E., Taha, A. Y., MacIntosh, B. A., Hibbeln, J. R., Majchrzak-Hong, S. F., Faurot, K. R., Rapoport, S. I., Cheon, Y., Chung, Y.-M., Berk, M., & Douglas Mann, J. (2012). Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. Prostaglandins, Leukotrienes and Essential Fatty Acids, 87(4), 135–141. https://doi.org/10.1016/j.plefa.2012.08.004

Ramsden, C. E., Zamora, D., Faurot, K. R., MacIntosh, B., Horowitz, M., Keyes, G. S., Yuan, Z.-X., Miller, V., Lynch, C., Honvoh, G., Park, J., Levy, R., Domenichiello, A. F., Johnston, A., Majchrzak-Hong, S., Hibbeln, J. R., Barrow, D. A., Loewke, J., Davis, J. M., … Mann, J. D. (2021). Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: Randomized controlled trial. BMJ, 374, n1448. https://doi.org/10.1136/bmj.n1448

Q: COVID-19 paper: Kothapalli, K. S. D., Park, H. G., & Brenna, J. T. (2020). Polyunsaturated fatty acid biosynthesis pathway and genetics. Implications for interindividual variability in prothrombotic, inflammatory conditions such as COVID-19. Prostaglandins, Leukotrienes and Essential Fatty Acids, 162, 102183. https://doi.org/10.1016/j.plefa.2020.102183

Goodrich, T. (2020, June 2). Does Consumption of Omega-6 Seed Oils Worsen ARDS and COVID-19? [Blog]. Yelling Stop. http://yelling-stop.blogspot.com/2020/06/does-consumption-of-omega-6-seed-oils.html

Dyerberg, J., & Jørgensen, K. A. (1982). Marine oils and thrombogenesis. Progress in Lipid Research, 21(4), 255–269. https://doi.org/10.1016/0163-7827(82)90011-X

McReynolds, C. B., Cortes-Puch, I., Ravindran, R., Khan, I. H., Hammock, B. G., Shih, P. B., Hammock, B. D., & Yang, J. (2021). Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections. Frontiers in Physiology, 12. https://doi.org/10.3389/fphys.2021.663869

Quote from Ralph Holman: "It seems reasonable to suggest that 18:3w3 intake be increased during pregnancy, lactation, and infancy, when the requirements for w3 PUFA are highest, during the development of the nervous system, which is rich in lipids containing high proportions of c3 PUFA. The mental apparatus of the coming generation is developed in utero, and the time to begin supplementation is before conception. A normal brain cannot be made without an adequate supply of w3 PUFA, and there may be no later opportunity to repair the effects of an w3 fatty acid deficiency once the nervous system is formed." Holman, R. T., Johnson, S. B., & Ogburn, P. L. (1991). Deficiency of essential fatty acids and membrane fluidity during pregnancy and lactation. Proceedings of the National Academy of Sciences of the United States of America, 88(11), 4835–4839. https://doi.org/10.1073/pnas.88.11.4835

Q: Seafood Nutrition Partnership:

https://www.seafoodnutrition.org/

Tom's bio there: https://www.seafoodnutrition.org/profile/tom-brenna/

Hibbeln, J. R., Spiller, P., Brenna, J. T., Golding, J., Holub, B. J., Harris, W. S., Kris-Etherton, P., Lands, B., Connor, S. L., Myers, G., Strain, J. J., Crawford, M. A., & Carlson, S. E. (2019). Relationships between seafood consumption during pregnancy and childhood and neurocognitive development: Two systematic reviews. Prostaglandins, Leukotrienes and Essential Fatty Acids, 151, 14–36. https://doi.org/10.1016/j.plefa.2019.10.002

Seychelles study (not Mauritius): Davidson, P. W., Leste, A., Benstrong, E., Burns, C. M., Valentin, J., Sloane-Reeves, J., Huang, L.-S., Miller, W. A., Gunzler, D., van Wijngaarden, E., Watson, G. E., Zareba, G., Shamlaye, C. F., & Myers, G. J. (2010). Fish consumption, mercury exposure, and their associations with scholastic achievement in the Seychelles Child Development Study. NeuroToxicology, 31(5), 439–447. https://doi.org/10.1016/j.neuro.2010.05.010

Q: "Talk to us a little bit about farmed vs. wild-caught fish. That's a big thing in the ancestral health community.":

Nichols, P. D., Glencross, B., Petrie, J. R., & Singh, S. P. (2014). Readily Available Sources of Long-Chain Omega-3 Oils: Is Farmed Australian Seafood a Better Source of the Good Oil than Wild-Caught Seafood? Nutrients, 6(3), 1063–1079. https://doi.org/10.3390/nu6031063

P.S. Discussion of Mark's Puder's research:

Anez-Bustillos, L., Dao, D. T., Fell, G. L., Baker, M. A., Gura, K. M., Bistrian, B. R., & Puder, M. (2018). Redefining essential fatty acids in the era of novel intravenous lipid emulsions. Clinical Nutrition, 37(3), 784–789. https://doi.org/10.1016/j.clnu.2017.07.004

Carlson, S. J., O'Loughlin, A. A., Anez-Bustillos, L., Baker, M. A., Andrews, N. A., Gunner, G., Dao, D. T., Pan, A., Nandivada, P., Chang, M., Cowan, E., Mitchell, P. D., Gura, K. M., Fagiolini, M., & Puder, M. (2019). A Diet With Docosahexaenoic and Arachidonic Acids as the Sole Source of Polyunsaturated Fatty Acids Is Sufficient to Support Visual, Cognitive, Motor, and Social Development in Mice. Frontiers in Neuroscience, 13, 72. https://doi.org/10.3389/fnins.2019.00072

"Mouse-o-pause", mouse menopause: Nehra, D., Le, H. D., Fallon, E. M., Carlson, S. J., Woods, D., White, Y. A., Pan, A. H., Guo, L., Rodig, S. J., Tilly, J. L., Rueda, B. R., & Puder, M. (2012). Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids. Aging Cell, 11(6), 1046–1054. https://doi.org/10.1111/acel.12006

Cunnane, S. C. (2003). Problems with essential fatty acids: Time for a new paradigm? Progress in Lipid Research, 42(6), 544–568. https://doi.org/10.1016/S0163-7827(03)00038-9

Quotable:

"The general idea that we call Evidence-Based Medicine, which, I'm afraid eliminates 95% of all the evidence that informs nutrition, and focuses 100% on human studies. Human studies are the worst studies. They are by far the worst. I don't think it's possible that a serious argument can be made otherwise."

"The food industry is not a bunch of evil guys who are just out to take everybody's money… So I'm not here to beat up food companies."

"Coconut's a seed, but it's a weird seed."

"Some species [of fish] will eat grain, and if they eat grain, then their fatty-acid profile will look like the grain you feed them."

"Salmon have the good sense to die if you don't feed them DHA."

"Farmed fish actually had a higher amount of DHA than the wild caught."

Brenna's Industrial Food Principle: "When we produce animal foods, their nutrient profile should match that of the wild-caught."

"It sounds like you're saying you're better off eating a farm-raised salmon than an industrially-raised chicken?" "Yeah, I'm probably going to get in trouble for saying that, but I think that's probably right."

"Otherwise, you've got the cheapest food in the world and the most expensive medicines in the world. Family physicians don't like stuff like that; pediatricians don't like stuff like that. We want to feed people well, and worry about medicine in well-fed people, rather than having to correct nutrient deficiencies by giving them drugs."

"Low linoleic acid maintains fertility."

"You'll often read in the medical literature that linoleic and alpha-linolenic are essential, and DHA and arachidonic are conditionally essential, and it sounds like they got it backwards." "They do. And it's a meme has never died, from the 1950s."

Jayne Rees Buxton, author https://thegreatplantbasedcon.com/books

Amazon: "The Great Plant-Based Con" https://amzn.to/3PdeV7A Using these Amazon link suppports this podcast, so thank you!

Amazon hardcover link (UK site): https://www.amazon.co.uk/dp/1408717441

Twitter https://twitter.com/JayneReesBuxton _______________________________________

Youtube version: https://youtu.be/X4BrcUyIci0

Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/

Tucker Goodrich Blog: http://yelling-stop.blogspot.com/ Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg Podcast: https://sites.libsyn.com/408758 Twitter: https://twitter.com/TuckerGoodrich _______________________________________ Show Notes **these are points we mention that I think people might want to read more about, or to explain or correct a point made. I don't inlude material from the book that we discuss, you'll have to get a copy to follow up on that information!

Colourful conman https://www.mcgill.ca/oss/article/controversial-science-health-news/colourful-conman

Obituary—Jay Dinshah, 66, American Vegan Society Leader https://ivu.org/news/oct2000/dinshah.html

"The Game Changers" movie https://amzn.to/3o3bu7n

Clark, M. A., Springmann, M., Hill, J., & Tilman, D. (2019). Multiple health and environmental impacts of foods. Proceedings of the National Academy of Sciences, 116(46), 23357–23362. https://doi.org/10.1073/pnas.1906908116

Banta, J. E., Lee, J. W., Hodgkin, G., Yi, Z., Fanica, A., & Sabate, J. (2018). The Global Influence of the Seventh-Day Adventist Church on Diet. Religions, 9(9), 251. https://doi.org/10.3390/rel9090251

O, 'Hearn Meghan, Lauren, B. N., Wong, J. B., Kim, D. D., & Mozaffarian, D. (2022). Trends and Disparities in Cardiometabolic Health Among U.S. Adults, 1999-2018. Journal of the American College of Cardiology, 80(2), 138–151. https://doi.org/10.1016/j.jacc.2022.04.046

"Oatly ads banned by UK watchdog over 'misleading' green claims" https://www.theguardian.com/media/2022/jan/26/oatly-ads-banned-by-uk-watchdog-over-misleading-green-claims

"Tesco plc" https://www.ethicalconsumer.org/company-profile/tesco-plc

"Protein content claims and methylcellulose in the spotlight as Beyond Meat hit with new lawsuits" https://www.foodnavigator-usa.com/Article/2022/06/03/Protein-content-claims-and-methylcellulose-in-the-spotlight-as-Beyond-Meat-hit-with-new-lawsuits

Physician's Committee for Responsible Medicine is run by Neal Barnard, not David Katz. https://www.pcrm.org/about-us

There are ~1 million physicians in the U.S. (https://www.statista.com/topics/1244/physicians/#topicHeader__wrapper), according to PCRM, they have 17,000 physician members (see link above), so that's 1.7% of practicing physicians as members. Of course the vast majority of the rest are *also* in favor of responsible medicine, so the name is a bit of a slander.

BBC Radio 4 interview (https://twitter.com/JayneReesBuxton/status/1525798657919963137) "Eating Meat, Inclusive Rents and Business Going Bust" https://www.bbc.co.uk/sounds/play/m0017cp5

(Thanks to David Wyant for the link! https://twitter.com/wyadvd/status/1548002099518091264)

"Honest Burgers is to convert its all-vegan V Honest site close to London's Leicester Square back to its core concept in July, just six months after launching the spin-off brand." https://www.bighospitality.co.uk/Article/2022/06/23/Honest-Burgers-to-convert-V-Honest-site-back-to-core-concept-after-just-six-months

Brian and I have an engaging chat with famed Paleo Diet advocate Robb Wolf on his recent book 'Sacred Cow', how his own health issues have kept him engaged in continuing to explore the relationship between diet and health, how he's going beyond Paleo with his new enterprise LMNT, and more. I hope you all enjoy!

Video for this episode: https://youtu.be/rrQ8q_ctGUQ

Robb Wolf https://robbwolf.com/

"Sacred Cow"

https://amzn.to/39bzKAe

Diana Rodgers, RD (co-author of "Sacred Cow")

https://sustainabledish.com/

https://twitter.com/SustainableDish

"The Paleo Solution" https://amzn.to/3x4TKwn

T. Colin Campbell's "The China Study" https://amzn.to/39azaml

Zero Acre Farms https://www.zeroacre.com/

*Fermentation, not "fertilization"!

Carbon cycle https://education.nationalgeographic.org/resource/carbon-cycle

EAT-Lancet Commission Summary Report https://eatforum.org/eat-lancet-commission/eat-lancet-commission-summary-report/

Omega Initiative TK

Mat Lalonde https://fatburningman.com/mat-lalonde-why-nutrient-density-matters-paleo-fails-what-to-eat-for-dinner/

Amber O'Hearn https://www.mostly-fat.com/

Ketogains https://www.ketogains.com/

LMNT https://drinklmnt.com/ Products: https://amzn.to/3Q211pk

Tim Noakes' "Waterlogged: The Serious Problem of Overhydration in Endurance Sports" https://amzn.to/38MxY8L

Stan Efferding https://stanefferding.com/

LMNT make your own sodium supplement: "11 Homemad Electrolyte Drink Recipes" -> Includes the Norcal Margarita I mentioned! https://drinklmnt.com/blogs/health/the-best-homemade-electrolyte-drink-for-dehydration

Roam Free Bison Ranch https://goroamfree.com/

"Restoring the land with the Savory Institute" https://www.youtube.com/watch?v=yVxLQtSqvbQ

_____________________________________________________

Co-host Dr. Brian Kerley https://www.seedoilrebellion.com/ https://twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils? Check out the Seedy app! https://www.seedyapp.com/

Tucker Goodrich Blog: http://yelling-stop.blogspot.com/ Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg Podcast: https://sites.libsyn.com/408758 Twitter: https://twitter.com/TuckerGoodrich

I interview Prof. Ameer Taha of U.C. Davis on linoleic acid, lipid peroxidation, oxLAMs, and neurodegeneration.

A great discussion going over some of the seminal research he has done during his career.

We also discuss his surprising dream research project, one I think would yield major benefits if he were able to pursue it...

This was originally released on David Gornoski's A Neighbor's Choice podcast:

https://aneighborschoice.com/professor-ameer-taha-on-lipid-oxidation-linoleic-acid-oxlams/

My thanks to David for permission to re-release it here.

Please subscribe to this podcast if you find this topic interesting!

My Youtube channel link is here: https://youtu.be/rk9NnC7bS3U

Here is Prof. Taha's page at U.C. Davis:

https://foodscience.ucdavis.edu/people/ameer-taha#/

Here's his PubMed research: https://pubmed.ncbi.nlm.nih.gov/?term=ameer+taha%5BAuthor%5D&sort=date

And his most recent (one I will be reading as soon as I finish posting this!):

"Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions "

https://pubmed.ncbi.nlm.nih.gov/35508275/

Blog:

https://yelling-stop.blogspot.com/

Twitter:

https://twitter.com/TuckerGoodrich

Meet the Seed Oil Disrespecter and his wife, Ashley. We talk about how and why they started doing what they are doing, and what they hope to accomplish, with a focus on how avoiding seed oils affected their family health even after eating a mostly healthy diet for many years. Some news at the end, so stick around! Seed Oil Disrespecter on Twitter: https://twitter.com/SeedOilDsrspctr

On Instagram: https://www.instagram.com/seedoildisrespecter/

Healthy Oil Respecter (Ashley) on Twitter: https://twitter.com/RealOilRspctr

On Instagram: https://www.instagram.com/seed_oil_rebellion/

Seed Oil Rebellion: https://www.seedoilrebellion.com/

My blog: https://yelling-stop.blogspot.com

Twitter: https://twitter.com/TuckerGoodrich

Podcast: https://sites.libsyn.com/408758

Youtube: https://youtu.be/hJcVSb0Rty8