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tv.qiagenbioinformatics.com episodes

  • Public single-cell expression data made easy with QIAGEN IPA

    Many QIAGEN Ingenuity Pathway Analysis (IPA) users have expressed strong interest in taking advantage of public single-cell expression data. Such data is readily available and easily accessible in IPA. We are hosting a 1hr training focused on some common use cases related to this topic.

    You'll learn to:

    • Easily locate single-cell studies, samples or cell types of interest

    • Study pathways and networks pertaining to such projects to explore biological and cellular mechanisms

    • Investigate sample- and cell-level gene expression for biomarker investigation

    1 hr 11 min
  • Supporting Biomarker Discovery One Cell at a Time - Introduction to QIAGEN...

    Single-cell gene expression analysis helps biologists and bioinformaticians reveal complex and rare cell populations, uncover regulatory relationships among genes and analyze and visualize gene expression differences among different cell types, or within a unique cell type. In this talk we will explore new tools for analyzing, interpreting and explore scRNA-seq data and the underlying biology. We will also show how to integrate ‘omics datasets from different platforms to gain insights into the biology and molecular drivers of specific cell populations.

    Objectives:
    How to analyze scRNA-seq data without a bioinformatician or learning code.
    How to leverage automatic cell annotation to streamline your workflow.
    How to quickly comb millions of cells to identify

    Click here to learn more.

    17 min
  • Discovery from public oncological data using QIAGEN Omicsoft OncoLand and...

    In this 90-minute training, we will discuss how to discover and validate biomarkers as well as drug targets and key genes using public oncological data from GEO, TCGA, CCLE and other sources. To do this, we will use QIAGEN Omicsoft OncoLand, QIAGEN Ingenuity Pathway Analysis (IPA) and the OmicSoft Land Explorer web interface.

    Specifically, for conditions of interest (diseases, cell lines, treatments etc.), we will discuss how to:

    • Identify public studies of interest
    • Derive a biomarker/gene signature
    • Study expression of a gene or drug target
    • Correlate expression of multiple genes and biomarkers
    • Visualize a gene signature in the context of a heatmap
    • Compare public data with other public data or a user’s own data

    Speaker: Sumana Chintalapudi, Ph.D., Field Application Scientist, QIAGEN Digital Insights

    1 hr 15 min
  • Novel discoveries from public single-cell RNA-seq data using QIAGEN OmicSoft...

    QIAGEN OmicSoft Lands and QIAGEN Ingenuity Pathway Analysis (IPA) provide a powerful resource for exploring curated pre-analyzed public single-cell RNA-seq studies and providing downstream biological insights for these data. In this training, we will review how OmicSoft Lands allows for the interrogation of identified cell types within public single-cell datasets of interest and subsequent exploration of their associated gene signatures. The biological context of these signatures can then be explored within QIAGEN IPA, identifying key pathways and their associated activity, as well as predicting regulatory molecules that could function as biomarkers or drug targets. In addition, the biological signatures found in relevant cell types can be evaluated through comparison with other pre-analyzed single-cell and bulk RNA-seq studies to explore the conservation of these biological signals.

    In this webinar you will learn how to:

    • Easily search and locate scRNA-seq projects of interest within QIAGEN OmicSoft Lands
    • Determine gene expression signatures associated with cell types of interest
    • Easily search and interpret pathway analyses of pre-analyzed single-cell studies within QIAGEN IPA
    • Quickly identify and interpret key biological pathways and regulatory networks within QIAGEN IPA
    • Compare the biological findings for a cell type to other single-cell and bulk gene expression studies
    • Export results in graphical and tabular formats of interest

    1 hr 26 min
  • Expression data analysis using QIAGEN Omicsoft Studio - Sep 28 2021

    In this training, users will learn how to generate downstream outputs such as heatmaps, differential expression tables, PCA/PCOA plots, box plots and other visualizations from their count or expression data (transcriptomics, proteomics, metabolomics, etc.).
    Attendees will learn how to:
    • Import either normalized or raw count data (transcriptomics, proteomics, metabolomics, etc.) into QIAGEN OmicSoft Studio
    • Generate downstream outputs such as differential expression tables, heatmaps, counts, PCA/PCOA, etc.
    • Export high resolution graphics as well as raw or filtered tables
    • Export results to QIAGEN Ingenuity Pathway Analysis
    • Deploy easy-to-use pipelines for RNA-seq/scRNA-seq/microarray data
    • Implement options for downloading or comparing public data (GEO, TCGA, etc.)
    Speaker: Eric Seiser, Ph.D. Field Application Scientist, QIAGEN Digital Insights

    1 hr 27 min
  • Drug treatment, toxicology and target safety assessment using QIAGEN...

    In this 90-minute training, users will learn how to do drug treatment, toxicology and target safety assessment related discoveries using QIAGEN Ingenuity Pathway Analysis (IPA) and QIAGEN Omicsoft Lands.

    Using public data from GTEx (normal tissue), GEO, cancer collections and more, attendees will learn how to use Omicsoft Lands to:

    • Investigate a drug target or biomarker expression across different normal tissues, disease conditions, treatments and more
    • Correlate expression of 2 or more genes
    • Identify a list of genes or biomarkers specific to treatment, disease, normal tissue, cell type and more

    Using findings from peer-reviewed publications and other sources, attendees will learn how to use QIAGEN IPA to:

    • Investigate the impact of targeting a gene/protein on different toxicological and biological functions
    • Derive tox findings for a gene of interest from QIAGEN IPA’s knowledgebase
    • Identify and study toxicity-related pathways, regulators and functions for an internal dataset or a public dataset
    • Compare different drug treatments, other conditions or multi-omics data for novel discoveries

    1 hr 25 min
  • Drug Target and Biomarker Investigation using OmicSoft OncoLand

    In this 90-minute training, attendees will learn how to use basic expression analysis functionalities in QIAGEN OmicSoft OncoLand. QIAGEN OmicSoft Single Cell Land will also be discussed, focusing on public single-cell data.

    Key focus will be on Biomarker discovery with QIAGEN OmicSoft OncoLand leveraging public oncology data from GEO, TCGA and other collections to:

    • Discover and validate biomarker expression in diseases, disease subtypes, treatments, cell types, etc.

    • Identify a list of biomarkers specifically expressed in disease, treatment group, cell type or other condition of interest
    • Overlay expression of a gene on cell clusters of interest from public single-cell data

    This training is designed for biologists, bioinformaticians, and data scientists.

    1 hr 14 min
  • Checkpoint inhibitors investigation in context of biomarkers, drug targets...

    This training will focus on how QIAGEN Omicsoft Studio and IPA can be used to discover new biomarkers, validate (or study) drug targets and identify novel mechanisms of action with user and/or public checkpoint inhibitor datasets from resources like GEO, SRA, TCGA and more.

    In this training, you will learn how to:
    · Investigate the expression of a gene/biomarker/drug target across different treatments and diseases
    · Derive a biomarker/gene signature from a specific condition (for example, non-responders of a drug, a specific disease/disease subtype and more)
    · Correlate expression of multiple genes and biomarkers
    · Compare different experimental groups (user and/or public data) at both gene expression and pathways/regulatory networks activity levels

    1 hr 25 min

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