Making sense of the Heavens above is extreme science. Add radio telescopes and that becomes multi dimensional. Then apply stresses that destroy 4 wheel vehicles in the desert and you have this week's Shirtloads guest.  Dr Karl and Professor Lisa (Harvey-Smith). Radio astronomer and Ultra Marathon Runner who quit formal schooling aged 11. Unique in the science fraternity and she is focused on big Science. In her own words "There are no Bigger questions than the ones being asked by astronomers. Where do we come from?  Where are we going? Are we alone?"