Radiology Lectures | Radquarters

Ultrasound of Epidermal Inclusion Cyst


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In this radiology lecture, we review the ultrasound appearance of epidermal inclusion cyst!

Key teaching points include:

  • Epidermal inclusion cyst is the most common cutaneous cyst.
  • Can occur anywhere: Head, neck, trunk, extremities.
  • Benign, keratin-containing cyst lined by a wall of stratified squamous epithelium.
  • On ultrasound, appears as a well-circumscribed, round to oval mass with broad (50%) contact with dermis, nonvascular and with posterior acoustic enhancement.
  • Hypoechoic to minimally hyperechoic with internal linear echogenic and anechoic debris = “Pseudotestis.”
  • Presence of a focal hypoechoic tract extending towards epidermis adds specificity = “Submarine sign.” May see overlying punctum on skin surface = Small, dark-colored opening.
  • Epidermal inclusion cysts are different from sebaceous cysts. Sebaceous cysts originate from sebaceous glands, contain sebum and are less common.
  • Epidermal inclusion cysts contain keratin, not sebum, but are often incorrectly referred to as sebaceous cysts.
  • Epidermal inclusion cyst vs. epidermoid cyst. Epidermoid cyst is a non-neoplastic cyst lined only by squamous epithelium. Epidermal inclusion cyst is a specific type of epidermoid cyst caused by implantation of epidermal elements in the dermis. All epidermal inclusion cysts are epidermoid cysts, but not all epidermoid cysts are epidermal inclusion cysts.
  • Can become ruptured or infected: Ill-defined or lobular margins, internal blood flow, peri-lesional soft tissue inflammation, adjacent fat focally hyperechoic or hyperemic. DDx for complicated epidermal inclusion cyst: Neurogenic tumors and other neoplasms.
  • Uncomplicated cysts typically do not require treatment, but if infected may require I&D or excision. Growing cysts may also require excision.
  • Rare (1%) malignant degeneration to squamous cell carcinoma, less commonly basal cell carcinoma.
  • References:

    Jacobson JA, Middleton WD, Allison SJ, et al. Ultrasonography of Superficial Soft-Tissue Masses: Society of Radiologists in Ultrasound Consensus Conference Statement. Radiology 2022; 304:18-30. https://pubs.rsna.org/doi/full/10.1148/radiol.211101

    To learn more about the Samsung RS85 Prestige ultrasound system, please visit: https://www.bostonimaging.com/rs85-prestige-ultrasound-system-4

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    The post Ultrasound of Epidermal Inclusion Cyst appeared first on Radquarters.

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    Radiology Lectures | RadquartersBy Daniel J. Kowal, MD

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