University of California Audio Podcasts (Audio)

Topology offers a way to organize complex data by looking for shape, structure, and relationships. Yusu Wang, Ph.D., UC San Diego, and Gunnar E. Carlsson, Ph.D., Stanford University, discuss how ideas from algebraic topology move from pure mathematics into data science, machine learning, and AI. Carlsson explains why topological data analysis helps identify meaningful groups in large data sets, how examples and accessible tools can make abstract math useful, and why interpretability matters as AI systems grow more complex. The conversation connects collaboration across fields, customer-focused entrepreneurship, and the need to train mathematicians and AI researchers to help formulate real-world problems. Their exchange shows how mathematical thinking can make powerful technologies more understandable, usable, and accountable. Series: "Data Science Channel" [Science] [Show ID: 41487]

Alzheimer’s disease can begin developing years before memory and thinking problems become noticeable. Iris Broce-Diaz, Ph.D., of UC San Diego is developing accessible, noninvasive, and cost-effective tools to help primary care physicians and neurologists identify people at higher risk earlier. Her models combine information from cognitive assessments, brain imaging, genetics, and PET scans to estimate the likelihood that mild cognitive impairment will progress within five years. Combining multiple measures improves the models’ ability to separate higher- and lower-risk patients. Broce-Diaz also plans to add women-specific factors, including menopause history, hormone therapy, reproductive history, endocrine markers, and symptoms. The goal is to support better referrals, guide monitoring, and help eligible patients consider treatment sooner. Earlier risk assessment could also strengthen clinical trials and make dementia care more useful across different health systems. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 41632]

Men with non-obstructive azoospermia may undergo microscopic testicular sperm extraction, or mTESE, without knowing whether sperm will be found. Kun Tan, Ph.D., of UC San Diego explains how molecular semen analysis could provide a noninvasive way to predict the procedure’s outcome. The assay uses stage-specific germ cell markers identified through single-cell RNA sequencing, then measures those markers in semen with qPCR. Because semen contains germ cells from different stages of sperm development, their molecular signals may reflect what is happening inside the testes. Tan shows how the assay predicts whether sperm retrieval was successful and can identify where sperm development may be blocked. The research could help couples planning IVF or ICSI avoid unnecessary surgery, reduce financial and emotional burdens, and receive more detailed information about male infertility before treatment.

Series: "Motherhood Channel" [Health and Medicine] [Show ID: 41630]

Archaeology can help communities understand environmental change, protect cultural heritage, and prepare for an uncertain climate future. Isabel C. Rivera-Collazo, Ph.D., of UC San Diego studies relationships among people, oceans, coastal ecosystems, and climate in Puerto Rico and the Caribbean. She explains how Hurricane Maria shifted her research from identifying theoretical vulnerabilities to supporting communities facing immediate risks. Her work combines archaeology with ecology, biology, geology, local histories, and community knowledge. Research on plants, fishing traditions, coral reefs, and coastal sites has supported sand dune restoration, heritage protection, and the creation of a marine protected area. Rivera-Collazo emphasizes that residents are experts on their own landscapes and should guide research priorities. Recovering knowledge from the past can strengthen identity, support ecosystem restoration, and help communities shape more resilient futures. Series: "Mi Universidad " [Science] [Education] [Show ID: 41490]

Chronic pain in older adults can affect mobility, mood, sleep, social connection, and independence. Una Makris, M.D., M.Sc., UC San Diego and VA San Diego Healthcare System, explains why musculoskeletal pain is common later in life and why medications or procedures alone may not meet the needs of many patients. Drawing on her work in rheumatology and geriatrics, Makris describes how pain and depression can reinforce each other, making it important to address both together. She highlights an age-friendly behavioral coaching approach that uses motivational interviewing, values-based goal setting, physical activity, and social support to help people reconnect with meaningful activities. By focusing on small, safe increases in movement, this research points to practical ways to support better function, quality of life, and healthy aging. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41172]

As part of the 2026 Developmental Disabilities Conference, Corinne Melon, Managing Director, Phamaly Theatre Company, talks about accessible theater for people with disabilities. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 41468]

As part of the 2026 Developmental Disabilities Conference, Chantel Burkitt, Senior Clinical Scientist, and Todd Dalberg, Pediatrician and Palliative Medicine Physician, Gilette Children's Hospital, discuss how to assess and manage pain for people with developmental disabilities. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 41471]

Authentic autism representation begins with listening to autistic people and including them in stories about their lives. Seth Bakke, producer, writer and director of The Rescue, explains how his autistic cousin Aaron and a poem by autistic typer Peter Tran inspired the film. Bakke describes working with Aaron on screen, consulting the Tran family and adapting the set to support his needs. Autistic typers Otto Lana and Peter Tran, joined by Steven Tran, a postdoctoral researcher at UC San Diego, discuss where the film reflects their experiences, where it simplifies communication through typing and why creative freedom must remain grounded in lived experience. They address presuming competence, the difference between hearing and listening, and the need for autistic actors and advisers. Their participation challenges stereotypes and helps audiences see they should be full participants in their own stories. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Arts and Music] [Show ID: 41175]

Scientific progress depends on curiosity, investment and the freedom to take risks. Nobel Laureate and UC San Diego alumnus Fred Ramsdell traces his path from community college to biotechnology and a discovery that reshaped understanding of immune regulation. He explains how decades of publicly funded research made that breakthrough possible and why failed experiments are essential steps toward discovery. Ramsdell discusses threats to federal research funding, the private sector’s limited tolerance for risk and the need for scientists to communicate clearly. Rebuilding trust, he argues, starts with listening, finding shared values and explaining how basic research leads to new treatments, economic value and national security. Sustained support for science matters because no one can predict where the next major breakthrough will begin.

Series: "Deep Look Public Speaker Series" [Science] [Show ID: 41113]

Climate and environmental change affect reproductive health and pregnancy in important ways. Dr. Marya Zlatnik explains how petrochemicals, climate change, and everyday chemical exposures can shape reproductive resilience and pregnancy outcomes. Zlatnik helps clarify how people can protect reproductive well-being in a changing climate with informed, resilience-building choices. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 41547]