University of California Audio Podcasts (Audio)

Water on Earth sustains and connects us, but human activities can increase levels of harmful microorganisms and pollutants in our water systems that have the potential to make us sick or threaten our food supply. Join microbial ecologist Dr. Sarah Allard as she presents emerging research from Scripps Oceanography that sheds light on how natural microbial systems respond to these harmful contaminants in systems as diverse as freshwater river ecosystems and marine invertebrate digestive tract microbiomes. Series: "Jeffrey B. Graham Perspectives on Ocean Science Lecture Series" [Science] [Show ID: 39249]

Alison Moore, M.D., M.P.H., F.A.C.P., discusses the keys to healthy aging: staying active, mentally engaged, socially connected, having a positive outlook, and being resilient. Dr. Moore emphasizes the importance of these factors for a long and healthy life. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39347]

Carla Kim, Ph.D., explains how aging impacts lung cell biology and its potential to reshape our understanding of diseases, including lung cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39254]

Dr. Stuart Finder, a renowned clinical ethicist, will discuss the meaning of ethics as it is encountered and understood in actual healthcare contexts. This lecture will explore what matters to patients, families, and healthcare professionals in real-world clinical settings. Using concrete examples, ranging from end-of-life choices to reproductive decisions, to simply coming up with appropriate care plans, Dr. Finder will show how clinical ethics is grounded in the real dynamics and complexities that drive contemporary healthcare practices. Series: "Ethics, Religion and Public Life: Walter H. Capps Center Series" [Health and Medicine] [Humanities] [Show ID: 39150]

Siddhartha Jaiswal, M.D., Ph.D., discusses clonal hematopoiesis and its impact on aging and diseases. Jaiswal highlights the role of genetic variations, focusing on a specific gene, TET2, and its link to clonal expansion. He explains that certain genetic variations can slow clonal expansion, potentially offering insights into treatments or interventions to mitigate its effects. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39260]

Astronaut Peggy Whitson, Ph.D., and Lisa Carnell, Ph.D., discuss various aspects of space exploration, life in microgravity, and the future of space science and research. They delve into the challenges astronauts face, from taste differences in space to innovative 3D printing solutions. The conversation also highlights the importance of stem cell research, personalized medicine, and drug development in space. Whitson's unique perspective offers insights into the awe-inspiring views of Earth from space and the collective responsibility to protect our planet. This thought-provoking discussion exemplifies the intersection of science, space exploration, and the promise of a future beyond our planet. Series: "Stem Cell Channel" [Science] [Show ID: 39073]

Ronald DePinho, M.D., explains how telomerase, typically linked to telomere maintenance, serves as a transcriptional co-activator in the brain. Epigenetic repression of TERT, the gene for telomerase, occurs with aging, contributing to aging hallmarks like cellular senescence and inflammation. DePinho's team developed a compound that reactivates TERT, which, when administered to mice, reverses age-related changes. It restores cognitive function, reduces amyloid plaque, and alleviates inflammation. This suggests that maintaining TERT levels can counteract age-related cognitive decline and neurodegeneration, offering potential for treating neurodegenerative diseases like Alzheimer's. DePinho's work expands our understanding of telomerase's multifaceted role in aging and neurodegeneration, holding promise for interventions against these age-related processes. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39071]

Leonard Zon, M.D., discusses cutting-edge research on the intricate relationship between macrophages, stem cells, and the development of leukemia using the zebrafish model. He delves into the fascinating interactions between these cell types, highlighting the role of a "don't eat me" signal and the influence of the leukemic niche. Through cellular barcoding and single-cell RNA sequencing, he unveils a potential therapeutic target which may offer promising insights into treating leukemia by disrupting the stromal activities that support it. Zon showcases the power of zebrafish models in advancing our understanding of hematopoiesis and cancer, promising new avenues for research and treatment. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39064]

An 800-foot-long stone path of words, KAHNOP • TO TELL A STORY is the 22nd public artwork commissioned by the Stuart Collection at UC San Diego. The text for the UC San Diego walkway draws from the writing of authors and scholars with ties to the University and its history. Organized by a spine of keywords composed by Ann Hamilton, this concordance of documents weaves together threads of thinking from many different disciplines. The piece was built line by line, rather than as a singular continuous narrative, and yet clear themes emerge and recur throughout the 1,300-line composition. A feminist narrative transcribed by two Kumeyaay scholars exists in bands situated at a regular interval throughout the entire length of the piece, creating its own cadence and rhythm within the larger whole. These juxtapositions form a field of text and an infinite number of paths to be composed and recomposed every time someone walks its surface. Series: "Stuart Collection at UC San Diego" [Arts and Music] [Show ID: 39374]

What drives longevity? Explore the keys to healthy aging in this panel discussion featuring leading experts in public health, nutrition, and medicine. You'll get a comprehensive analysis of how lifestyle choices, diet, and exercise profoundly impact our healthspan and longevity. The panelists discuss the significance of the Mediterranean diet, the role of physical activity in maintaining wellness, and the potential benefits of medications like Metformin for non-diabetic patients. This engaging session also highlights the crucial influence of our environment and social structures on individual health behaviors. Discover actionable insights and the latest scientific findings on aging gracefully and improving your quality of life. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39127]