University of California Video Podcasts (Video)

Alysson Muotri discusses modeling Pitt-Hopkins syndrome (PTHS) using stem cells and brain organoids. He shares how rescuing TCF4 expression with CRISPR-mediated epigenetic induction of AAV vector delivery provides a gateway for targeted therapeutics for PTHS and related conditions. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38516]

Rob Stone is a member of the infrastructure team at Meta, focusing on next generation optics and networking. Prior to Facebook, Rob was a distinguished engineer at Broadcom within the switch architecture team. He is active in industry communities including IEEE and other MSAs. Rob holds a D.Phil. in Physics from The University of Oxford. Series: "Institute for Energy Efficiency" [Science] [Show ID: 38463]

The human brain has a larger mass with respect to body weight, increased cortical neurons with respect to size, an expanded proliferative zone, and unique connectivity patterns. Human-specific neurodevelopment is not only marked by physical differences, but also by temporal changes. Human neurons, during both prenatal neurodevelopment and adult neurogenesis, exhibit an exceptionally delayed time course, a characteristic termed neoteny. Signatures of human-specific neoteny have been observed and reproduced across different systems including induced pluripotent stem cell (iPSC) and brain organoids models. We compared neurogenesis across stem cells from five primate species - rhesus, gorilla, bonobo, chimpanzee, human - and assessed the differences in transcriptional dynamics. We identified a pioneer transcription factor, GATA3, that exhibited elevated neuronal expression only in humans. This finding provides evidence for the divergence of gene regulation as a contributor to human neoteny. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38301]

When not teaching at the University of Pennsylvania, CJ Taylor is part of the Robotics team working on The Institute for Learning-Enabled Optimization at Scale (TILOS) at UC San Diego's Halıcıoğlu Data Science Institute. He talks with Saura Naderi about his upbringing, his early interest in data science and his current position. He also talks about his involvement in projects that benefit the community. Series: "Science Like Me" [Science] [Show ID: 38501]

The American Physical Society has designated UC San Diego’s Mayer Hall as a historic site in recognition of research conducted by physicists Walter Kohn and Lu Jeu Sham on density functional theory. Their development of the "Kohn-Sham equation" inside Mayer Hall became the foundation for the computation of the material properties of electrons and nuclei. Understanding the electronic properties of complex systems is essential to the design and engineering of new materials and drugs. Kohn and Pierre Hohenberg on sabbatical in Paris developed a theorem for the electron ground state energy to depend on the electron density distribution instead of the usual potential energy due to the nuclei. In Building C (later named Mayer Hall), from 1964-66, Kohn and Sham laid the foundation of a computation method, based on a single-particle equation composed of its quantum kinetic energy and the potential energy including the interaction effects. [Science] [Show ID: 38313]

Epilepsy is a frequent co-morbidity in those with autism spectrum disorder (ASD). Maria Augusta Montenegro, M.D., Ph.D., discusses how cognitive abilities, motor deficit, and other associated symptoms can be factors, how epilepsy can be diagnosed, and recommended treatment options. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Show ID: 38389]

What is gene therapy and how does it relate to autism? Alysson Muotri, Ph.D., contextualizes the autism spectrum, defines gene therapy, shares how human stem cells can contribute to research, and lays out how gene therapy could be used in the future. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 38387]

John E. Bowers holds the UC Santa Barbara Fred Kavli Chair in Nanotechnology and is the Director of the Institute for Energy Efficiency and a Distinguished Professor in the Department of Electrical and Computer Engineering. Dr. Bowers received his M.S. and Ph.D. degrees from Stanford University and worked for AT&T Bell Laboratories and Honeywell before joining UC Santa Barbara. Dr. Bowers is a member of the National Academy of Engineering, the National Academy of Inventors, a fellow of the IEEE, OSA and the American Physical Society. Series: "Institute for Energy Efficiency" [Science] [Show ID: 38470]

How do we move from purpose to action? Fundación Tú Más Yo focuses on community development through education and collaboration. Toñe Beguerisse and Dalia Rodriguez speak with Morgan Appel about how they implement programs and work directly with communities to create change. Series: "Education Channel" [Public Affairs] [Humanities] [Education] [Show ID: 38414]

Diversity is a hallmark in autism yet autism research does not capture the full heterogeneity of individuals on the spectrum. Constance Smith-Hicks, M.D., Ph.D., Bradley Schlaggar, Ph.D., Ebony Holliday, Ph.D., and Omar Shanta discuss the current state of diversity research in autism and the roadblocks to include individuals of diverse backgrounds and abilities as participants in autism research as well as the strategies that could address these challenges. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Show ID: 38390]