A new UN report finds climate change is accelerating, and humans might be running out of time to reverse it. Also, the Taliban gains ground in Afghanistan, seizing control of more key areas. And, victims of opioids are detailing how the painkillers hurt their families, as a judge hears final arguments in the bankruptcy trial of Purdue Pharma.

This week's bonus episode of Up First comes from NPR's Short Wave. Caregivers in the "Sandwich Generation" have reported a steep decline in mental health, as did others who had to juggle changes in the amount of caregiving they had to provide to loved ones. Caregivers have struggled with anxiety, depression and PTSD at rates much higher than those without caregiving roles. NPR correspondent Rhitu Chatterjee talks about the study and her reporting with Emily Kwong.

As the delta variant spreads, more kids are getting sick with COVID-19: what symptoms to look for as students go back to school. Plus, the latest on violence in Afghanistan as U.S. troops come home. And a Senate vote could move infrastructure spending one step closer to the President's desk.

As the delta variant surges in Florida, school districts are defying the governor and sticking with mask mandates. Also, businesses clamor for workers as customer demand rebounds. And, an Olympic sprinter from Belarus is speaking out about why she refused to return home.

The World Health Organization is asking wealthy nations to stop giving out COVID-19 vaccine booster shots while people in poorer countries wait for their first dose. Also, the Biden administration looks to roll out new auto emissions rules, in hopes of boosting electric vehicle sales and slowing climate change. And, there's a public inauguration ceremony for Iran's new president today, as he faces pressure to lift U.S. sanctions that are crippling Iran's economy.

A growing list of top Democrats — including President Biden — are calling on New York Gov. Andrew Cuomo to resign after an investigation by the state's attorney general found Cuomo sexually harassed 11 women. Also, the CDC has issued a new temporary eviction ban, days after an earlier moratorium expired. And, the largest city in the U.S., New York City, will soon require proof of vaccinations if you want to eat indoors or go to a show.

Florida now leads the nation in new COVID-19 cases, and experts say it may be weeks before the surge begins to wane. Also, the Biden Administration is poised to deliver 110 million vaccine doses around the world. And, state lawmakers from Texas and several other states are descending on Washington, D.C. today to urge Congress to approve a new voting rights law.

The delta variant is leading to a surge in new COVID-19 cases, along with growing calls for tougher restrictions. But officials also report vaccinations are on the rise, especially in some hotspots. Also, the CDC's eviction moratorium comes to an end, after Congress fails to extend it, leading to new worries that many Americans could lose their homes. And, NPR speaks to Education Secretary Miguel Cardona about the roadmap to getting kids back in school for in-person learning.

This week's bonus episode of Up First comes from NPR's Throughline. The Olympics originated in Ancient Greece and were resurrected in the 1890's after a 1,500 year ban. Since then, the International Olympic Committee has been behind every Olympic Games. This episode explores the story of how the IOC turned the Olympics into a huge commercial success and whether the cities that host the games end up winning or losing.

As the CDC tracks the delta variant and tells vaccinated Americans in high-risk areas to mask up, experts are warning about further mutations of the coronavirus. President Biden is adapting his messaging to the changing pandemic. And an update on wildfires tearing across many western states.