In this episode, Nirmish Shah, MD, speaks about updates in the management of sickle cell disease (SCD), including the clinical utility, side effects, and appropriate monitoring of crizanlizumab, voxelotor, and L-glutamine for pediatric patients with SCD. Dr Shah also discusses the appropriate adjuvant agents for 3 pediatric patients in various clinical scenarios and reviews preliminary data from ongoing clinical trials in SCD.