🧬 Can we rejuvenate the aging immune system?

A new Nature Aging trial suggests we might be closer than we thought.

In 50 healthy adults aged 45–70, urolithin A—a mitophagy activator—improved immune fitness over just 28 days:

✅ ↑ naïve CD8⁺ T cells

✅ ↓ exhaustion markers (TOX)

✅ ↑ mitochondrial biogenesis (PGC-1α)

✅ ↑ fatty-acid oxidation capacity

✅ ↑ NK cell and monocyte function

✅ ↑ bacterial phagocytosis

💊 Well-tolerated with minimal adverse events

🔬 This builds on compelling translational work linking mitochondrial quality control to immunosenescence and "inflammaging."

A reminder that metabolism and immunity are deeply intertwined—and that targeted interventions may help preserve immune resilience across the lifespan.

🧠 Aging isn't just years lived. It's biology modulated.

#LongevityScience #Immunology #HealthyAging #Mitochondria #ClinicalResearch #TranslationalScience #Geroscience #ImmuneHealth #NatureAging