On this week's episode, Dr. Samreen Vora highlights the intersection of simulation with quality and safety as she interviews guest Karen Mathias, clinical nurse specialist and director of Children's Simulation Center. We discuss how simulation can be used across a healthcare system to prepare for a global pandemic, as well as react to ever changing conditions while providing care in the midst of one. Taking lessons from Ebola preparation and applying them to COVID-19, simulation is able to reduce not only staff anxiety during patient care but also risk to patients and staff during these unprecedented times.