He came from a noble Northumbrian family in Britain, and was tonsured a monk in 653 at Lerins in Gaul. In 669 he was made Abbot of the Monastery of Saints Peter and Paul in Canterbury. He traveled to Rome in 671 to be instructed in monastic practice according to the Rule of Saint Benedict (of Nursia). Returning to Northumbria he established two new monasteries, the first to follow St Benedict's Rule in the British Isles. He went to Rome once again in 678-679, this time bringing back the archcantor of St Peter's, who taught the monks of St Benedict's monasteries the chant and liturgical practices used in Rome.

Under the holy abbot's guidance, these monasteries became flourishing centers of Christian worship, scholarship and art. The Venerable Bede (May 26) was one of his disciples. Saint Benedict reposed in peace in 689 or 690, having greatly strengthened the Church and the Christian faith in Britain.