VJHemOnc Podcast

The introduction of Bruton's tyrosine kinase (BTK) inhibitors into the treatment landscape for mantle cell lymphoma (MCL) has transformed the field and provided patients with a promising therapeutic option. In this podcast, you will hear from leading experts who discuss the value of these agents in MCL, sharing updates from EHA 2024.

Tune in as Manali Kamdar, MD, University of Colorado Cancer Center, Denver, CO, Tycel Phillips, MD, City of Hope, Duarte, CA, Chan Cheah, MBBS, Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia, and Alexey Danilov, MD, PhD, City of Hope, Duarte, CA, share insights into the impact of BTK inhibitors on patient outcomes, the nuances between covalent and non-covalent BTK inhibitors, and further discuss ongoing trials evaluating these agents.

In today’s VJHemOnc podcast, we will be sharing novel developments in lower-risk myelodysplastic syndromes (LR-MDS) and important practical considerations when treating patients.

You will hear from experts Amer Zeidan, MBBS, Yale University and Yale Cancer Center, New Haven, CT, Rena Buckstein, MD, FRCPC, Odette Cancer Research Program, Sunnybrook Research Institute, Toronto, Canada, Guillermo Garcia-Manero, MD, University of Texas MD Anderson Cancer Center, Houston, TX, and Andrew Brunner, MD, Massachusetts General Hospital, Boston, MA. They discuss important considerations for physicians when treating LR-MDS, providing valuable insights into some of the common pitfalls in clinical practice which may lead to suboptimal responses in patients.

BCMA-targeting bispecific antibodies treat multiple myeloma by binding to BCMA on malignant plasma cells and directing T-cells to initiate targeted cell killing. This podcast provides updates on the use of BCMA-targeting bispecific antibodies in relapsed/refractory (R/R) multiple myeloma from the 2024 American Society of Clinical Oncology (ASCO) Meeting and the 29th Congress of the European Hematology Association (EHA).

You will hear from Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, who discusses updated data from the MagnetisMM-3 trial (NCT04649359) of elranatamab and real-world findings from a French compassionate use program using this agent. Rahul Banerjee, MD, FACP, Fred Hutchinson Cancer Center, Seattle, WA, provides insights into the real-world step-up dosing of teclistamab to mitigate toxicities. Finally, Sundar Jagannath, MD, Tisch Cancer Institute at Mount Sinai, New York, NY, discusses a matched adjusted indirect comparison (MAIC) of the novel bispecific linvoseltamab with teclistamab, and the sequencing of bispecific antibodies with CAR T-cells. 

In today's VJHemOnc podcast, we will be sharing key updates in the treatment of chronic lymphocytic leukemia (CLL) and Richter’s transformation (RT) from the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.

You will hear from experts Toby Eyre, MBChB (Hons), DipMedEd, MRCP (UK), FRCPath (UK), MD, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, and Lydia Scarfò, MD, Vita-Salute San Raffaele University & IRCCS San Raffaele Scientific Institute, Milan, Italy, who will discuss combinations of BTK and BCL2 inhibitors, the efficacy of BTK degraders in CLL, and the role of epcoritamab in the treatment of RT. 

Welcome to today's VJHemOnc podcast episode, where we will be sharing key highlights from the 2024 International Symposium on Amyloidosis (ISA), which was held in Rochester, MN. This podcast covers a variety of unmet needs in light chain (AL) amyloidosis, as well as emerging trials in the field.

Join leading experts Mario Nuvolone, MD, PhD, University of Pavia, Pavia, Italy, Vaishali Sanchorawala, MD, Boston University School of Medicine, Boston, MA, Patrick Hagen, MD, Loyola University Medical Center, Chicago, IL, and Efstathios Kastritis, MD, University of Athens School of Medicine, Athens, Greece, as they discuss the critical importance of early diagnosis in AL amyloidosis, exciting clinical trials in progress, patient selection for stem cell transplantation (SCT), and more.

While there have been advances in the treatment of lower-risk myelodysplastic syndromes (LR-MDS) in recent years, one major challenge that remains is the treatment of patients following the failure of erythropoiesis-stimulating agents (ESAs).

In this podcast, experts Amer Zeidan, MBBS, Yale Cancer Center, New Haven, CT, Valeria Santini, MD, University of Florence, Florence, Italy, and Courtney DiNardo, MD, MSCE, The University of Texas MD Anderson Cancer Center, Houston, TX, delve into the historical context of treatment developments, sharing insights on the emergence of novel agents like luspatercept and imetelstat. They explore the current paradigm for managing LR-MDS, including the strategic use of hypomethylating agents (HMAs) and other innovative therapies. The experts also touch on the future of clinical trials and the importance of early intervention in improving quality of life (QoL) and survival for patients.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic malignancy originating from plasmacytoid dendritic cells, characterized by skin lesions and frequent involvement of bone marrow and lymphoid tissues. Patients have a poor prognosis, making early diagnosis and advanced treatments, including targeted therapies, crucial for improving outcomes.

In this podcast, Naveen Pemmaraju, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Marina Konopleva, MD, PhD, Albert Einstein College of Medicine, New York City, NY, and Emanuele Angelucci, MD, Armando Businco Oncology Hospital, Sardegna, Italy, discuss the treatment and monitoring of BPDCN. They highlight the role of CD123-targeting agents, including tagraxofusp, the involvement of the central nervous system (CNS), and share strategies for treating adolescents and young adults (AYAs) with this aggressive disease.

Immunotherapeutic approaches, including CAR T-cells and bispecific antibodies, have become well-established in later lines of non-Hodgkin lymphoma (NHL) treatment. CAR T-cells are engineered to target specific antigens expressed on lymphoma cells, and bispecific antibodies simultaneously bind to both tumor cells and immune cells, enhancing the immune response against NHL.

This podcast features experts Anna Sureda, MD, PhD, Catalan Institute of Oncology, Duran I Reynals Hospital, Barcelona, Spain, who discusses the future of CAR-T therapy and the risk of secondary malignancies, and Manali Kamdar, MD, University of Colorado Cancer Center, Denver, CO, who gives an overview of the currently approved CAR-T products and bispecific antibodies in large B-cell lymphoma, and the optimal sequencing of these agents. 

The 17th International Workshop on Multiple Myeloma (iwMyeloma 2024) was held recently in Miami, FL, and brought together experts from around the world to discuss the latest updates, challenges, and research in the field.

In this episode, Ola Landgren, MD, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, Suzanne Lentzsch, MD, PhD, Columbia University, New York, NY, Thomas Martin, MD, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, and Suzanne Trudel, MSc, MD, Princess Margaret Cancer Centre, Toronto, Canada, discuss the use of various agents in myeloma, including the suitability of bisphosphonates to treat bone disease, and updates with the use of isatuximab and belantamab mafodotin. The experts also share their thoughts on the benefits of using measurable residual disease (MRD) as a surrogate endpoint in clinical trials.

Myelofibrosis (MF) is a hematologic malignancy that causes progressive bone marrow fibrosis and presents with other clinical manifestations, including anemia and splenomegaly. MF-related anemia can be challenging to manage, and strategies are being explored to improve outcomes for patients.

Today's VJHemOnc podcast features experts Mary Frances McMullin, MD, Queen’s University, Belfast, UK, who discusses strategies to manage anemia in MF, and Claire Harrison, MD, FRCP, FRCPath, Guy’s & St Thomas’ NHS Foundation Trust, London, UK, who gives a comprehensive overview of promising MPN clinical trials in the UK, and further discusses how to approach young patients with MPNs.