VJHemOnc Podcast

Many clinical trials are currently investigating the potential benefits of interferons in the treatment of myeloproliferative neoplasms (MPNs), in particular for polycythemia vera, essential thrombocythemia and myelofibrosis. Interferon-alfa was originally explored for MPN treatment many years ago, however it’s frequent dosing and toxicity profile present barriers to widespread use. More recently, ropeginterferon-alfa-2b-vjft reported promising results for patients with polycythemia vera in the PROUD and CONTINUATION-PV clinical trials (NCT01949805; NCT02218047) and is now being reviewed for approval by the FDA. Pegylated-interferon-alfa has also demonstrated efficacy.

In this podcast, we hear from Richard Silver, MD, and Nicole Kucine, MD, MS, both from the Weill Cornell Medical College, New York, NY, who share the latest clinical updates on the use of interferons for the treatment of polycythemia vera and essential thrombocythemia, as presented at the Texas MPN Workshop: Second Annual Workshop and Meeting in 2021.

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Real-world data gained through scientific studies is essential in the advancement of treatments for all hematological malignancies. Historically, pharmaceutical companies have been restricted to randomized clinical trials as their only form of testing a treatment; however, due to technological advancement, there are now ways in which data from real-world treatment settings can be collected by clinical researchers. Real-world data is used to support decision making regarding the usage, overall benefits, and risks associated with specific drugs and therapeutic combinations.

In this podcast, David Miklos, BSc, MD, PhD, of Stanford University, Stanford, CA, Elena Zamagni, MD, PhD, of the University of Bologna, Bologna, Italy, Heinz Ludwig, MD, of the Wilhelminen Cancer Research Institute, Wilhelminenspital, Vienna, Austria, and Andrea Visentin, MD, PhD, of the University of Padua, Padova, Italy, discuss some of the latest real-world data to have been shared in the fields of lymphoma, myeloma and chronic lymphocytic leukemia (CLL) at the European Hematology Association (EHA) Congress 2021.

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Over the past two decades the treatment landscape for non-Hodgkin lymphoma (NHL) has rapidly evolved, with the development of Bruton’s tyrosine kinase (BTK) inhibitors making a particularly significant impact and opening the door to the possibility of chemotherapy-free regimens. In 2013, ibrutinib became the first BTK inhibitor to receive FDA approval for the treatment of follicular lymphoma, followed by approvals for Waldenström’s macroglobulinemia and marginal zone lymphoma in 2015 and 2017 respectively. Since then, the BTK inhibitors acalabrutinib and zanubrutinib have received FDA approval and many trials are exploring novel BTK inhibitors and combinations.

In today’s episode, Thomas Witzig, of the Mayo Clinic Rochester, Rochester, MN, Chan Yoon Cheah, of the Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia, Gilles Salles of the Memorial Sloan Kettering Cancer Center, New York City, NY, and Paolo Ghia of Università Vita-Salute San Raffaele, Milan, Italy, talk on the latest data from key clinical trials of BTK inhibitors for the treatment of NHL.

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Research into the treatment of non-Hodgkin lymphoma (NHL) has made great progress within the last decade, with clinical trials such as the TRANSCEND-OUTREACH-007 and ZUMA-12 studies successfully advancing into later phases. Although there are currently various approaches to NHL treatment, primarily employing chemotherapy, steroid medication and allogeneic stem cell transplantation, such approaches are not tolerated by all patients and may not achieve complete remissions, creating an opening for immunotherapies to address these challenges. Given the recent FDA approvals of chimeric antigen receptor T-cell (CAR-T) therapies such as idecabtagene vicleucel and lisocabtagene maraleucel, much attention has now turned to the potential of these novel cellular therapies for more effective treatment of NHL.

In this podcast, Jeremy Abramson of the Massachusetts General Hospital Cancer Center, Boston, MA, Sattva Neelapu of the University of Texas MD Anderson Cancer Center, Houston, TX, Stephen Schuster of the Perelman School of Medicine, Philadelphia, PA, Barbara Savoldo of the University of North Carolina at Chapel Hill, Chapel Hill, NC, Max Mamonkin of the Baylor College of Medicine, Houston, TX, and Susan Prockop of the Memorial Sloan Kettering Cancer Center, New York, NY, discuss the latest clinical updates on T-cell therapies for NHL, highlighting therapies such as lisocabtagene maraleucel and axicabtagene ciloleucel.

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Immunotherapies are showing increasingly promising results for the treatment of patients with non-Hodgkin lymphoma (NHL) and, in particular, bispecific antibodies have demonstrated promising clinical results in heavily pre-treated patients. Several bispecific antibodies have entered the early stages of clinical trials since the approval of the CD19/CD30 bispecific antibody blinatumomab, and recently CD20/CD3 bispecific antibodies have demonstrated encouraging response rates in patients with both aggressive and indolent NHL.

In today’s podcast, Stephen Schuster from the Perelman School of Medicine, Philadelphia, PA, Franck Morschhauser from Lille University Hospital, Lille, France, and Rajat Bannerji from the Rutgers Cancer Institute of New Jersey, Newark, NJ, discuss the latest data on CD20/CD3 bispecific antibodies for the treatment of patients with NHL, in particular talking on mosunetuzumab, CD20-TCB and odronextamab, previously known as REGN1979.

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