VJHemOnc Podcast

Myelodysplastic syndromes (MDS) represent a range of disorders characterized by morphologic dysplasia, cytopenias, and a risk of progression to acute myeloid leukemia. With hematopoietic stem cell transplantation representing the only curative option for patients with MDS, the field has not seen the rapid evolution in treatments witnessed in other hematological malignancies.

In this podcast, Amer Zeidan, MBBS, Yale University, and Yale Cancer Center, New Haven, CT, chairs a discussion evaluating issues pertaining to MDS, from clinical trial designs to the latest understanding of disease biology as well as future outlooks. Dr Zeidan is joined by Amy DeZern, MD, MHS, of Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, Michael Savona, MD, of Vanderbilt University Medical Center, Nashville, TN, Mikkael Sekeres, MD, MS, of The Cleveland Clinic, Cleveland, OH, and David Steensma, MD, Dana-Farber Cancer Institute, Boston, MA.

The post The MDS sessions: clinical trial participation, endpoints & approvals appeared first on VJHemOnc.

The BCL-2 inhibitor venetoclax has been evaluated in many hematological malignancies, including acute myeloid leukemia (AML). More recently, emerging mechanisms of resistance and future directions of venetoclax in combination with hypomethylating agents and IDH inhibitors have been evaluated and data presented at EHA 2020, as well as SOHO 2020 has shown promising results in AML.

In this podcast, Naval Daver, of The University of Texas MD Anderson Cancer Center, Houston, TX, leads an exciting discussion alongside Courtney DiNardo and Marina Konopleva, also from The University of Texas MD Anderson Cancer Center, as well as Andrew Wei of Monash University, Melbourne, Australia, on the latest updates in the use of venetoclax-based regimens for the treatment of AML.

The post The AML Sessions: Venetoclax-based regimens appeared first on VJHemOnc.

IDH mutations are present in 20% of acute myeloid leukemia (AML) patients and the use of IDH-targeting agents has shown favorable clinical responses in AML, with ivosidenib and enasidenib (IDH1 and IDH2 inhibitors) being approved by the US F.D.A for relapsed/refractory AML patients.

In this podcast, Amir Fathi of Massachusetts General Hospital, Boston, MA, chairs a panel discussion evaluating the use of IDH inhibitors in AML and myelodysplastic syndromes, the potential of combination therapies using these agents, and the development of differentiation syndrome in AML. Dr Fathi is joined by Stephane De Botton of Gustave Roussy Institute, Villejuif, France, and Daniel Pollyea of the University of Colorado, Denver, CO.

The post The AML Sessions: IDH inhibitors appeared first on VJHemOnc.

Acute myeloid leukemia (AML) has seen rapid progression in the field of immuno-oncology which has led to vast improvements in patient outcomes. The annual Society of Hematological Oncology (SOHO) allowed for discussions on the translation of key data into clinical practice, including the state of the art in immunotherapy for AML.

In this podcast, Marion Subklewe of LMU Hospital Munich, Munich, Germany, leads a panel discussion evaluating checkpoint inhibitors, anti-CD47 therapy, BiTEs, and CAR T-cell approaches in AML alongside Naval Daver of the University of Texas MD Anderson Center, Houston, TX, David Sallman of H. Lee Moffit Cancer Center, Tampa, FL and Amer Zeidan of Yale University and Yale Cancer Center, New Haven, CT.

The post The AML Sessions: Immunotherapy appeared first on VJHemOnc.

Cell therapy involves the transplantation of viable cells into a patient in order to trigger a medicinal effect. CAR-T is a popular form of cell therapy, specifically immunotherapy, that can use a patient’s own altered immune cells to fight cancer.

In this podcast, Annalisa Ruggeri, MD, of IRCCS OSpedale Pediatrico Bambino Gesu, Noopur Raje, MD, of Massachusetts General Hospital, Matthew Frigault, MD, of Massachusetts General Hospital, and Maksim Mamonkin, PhD, of Baylor College of Medicine discuss key updates and clinical trial results in the field of CAR-T and cellular therapies presented at EBMT 2020.

The post Advances in CAR-T and cellular therapy from EBMT 2020: MSCs, clinical trial updates and gene-edited effector cells appeared first on VJHemOnc.