VJHemOnc Podcast

CAR T-cell therapy presents the opportunity to completely revolutionize the treatment of multiple myeloma, with research currently exploring the optimal targets and efficacy of these new agents. In this podcast, recorded at the Myeloma 2018 meeting in San Diego, CA, David Siegel, MD, PhD, of the John Theurer Cancer Center, Hackensac, NJ, chairs a discussion with Andrew Spencer, MBBS, FRACP, FRCPA, DM, of Alfred Hospital, Monash University, Melbourne, Australia, and Ravi Vij, MD, MBA, of Washington University Medical School, St. Louis, MO. They discuss the current landscape of CAR T-cell therapy, including exploratory targets, the cost vs. value of this treatment, and consider the question of where CAR T-cells will be best placed in the treatment sequence.

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CAR T-cells have demonstrated impressive efficacy in a variety of hematological malignancies, but their use in chronic lymphocytic leukemia (CLL) is still relatively new. In this podcast, Deborah Sims, CLL patient and advocate, and Brian Koffman, MD, CLL patient, and founder and medical director of the CLL society, discuss their experiences with the disease, and Brian’s recent treatment with CAR T-cells. They speak about their respective treatment routes, CAR T-cell toxicity and efficacy, the use of measurable residual disease (MRD) as an indicator of treatment success, and the future of CLL treatment. This discussion took place at the 23rd Congress of the European Hematology Association (EHA) 2018.

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Chronic lymphocytic leukemia (CLL) is experiencing a revolution in its treatment approaches. New therapies are constantly in development, and the past few years have seen an influx of highly effective novel therapies. In this podcast, Jennifer Woyach from the Ohio State University Comprehensive Cancer Center, Chris Fegan of Cardiff University, Anthony Mato from the Memorial Sloan Kettering Cancer Center, Michael Hallek from CECAD of Cologne, Peter Hillmen from Leeds Teaching Hospital NHS Trust, and William Wierda of the MD Anderson Cancer Center, discuss the current treatment landscape, as well as what the future holds for CLL therapies.

This podcast explores current challenges in CLL treatment, including the use of CAR T-cells, the variety of novel therapies on the market, and the huge potential benefits of novel agent combinations. The interviews included were recorded at the British Society for Hematology (BSH) 2018 Annual Meeting, the American Society of Oncology (ASCO) 2018 Annual Meeting, and the 23rd Congress of the European Hematology Association (EHA) 2018.

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Over the last several years, CAR T-cell therapy has emerged as a revolution in immunotherapy, with incredible results to date. In this podcast, we look at the results of recent trials, the challenges being faced with the use of this novel therapy and advancements that we will be seeing in the future. This podcast features Tanya Siddiqi of the City of Hope National Medical Center, Faith Davies of UAMS Myeloma Institute, Rose Ellard from King’s College Hospital NHS Foundation Trust, Marion Subklewe of LMU Hospital Munich, Noelle Frey from the University of Pennsylvania, Stephen Robinson of University Hospitals Bristol NHS Foundation Trust, and Yi Lin from the Mayo Clinic.

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Measurable residual disease (MRD) has been a hot topic of interest due to its potential applications in the clinical setting. MRD measurement can help determine treatment efficacy, disease prognosis and guide disease management. In this podcast, Bijal Shah of the H. Lee Moffitt Cancer Center & Research Institute in Tampa, Richard Dillon from King’s College London, Todd Druley of Washington University School of Medicine in St. Louis and Ola Landgren of Memorial Sloan Kettering Cancer Center explore the exciting realm of MRD.

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