Politico reporter Lisa Kashinsky and Gary Daffin, co-chair of the Massachusetts Gay and Lesbian Political Caucus, join us to discuss what they'll be keeping an eye on across the political landscape in 2022.

Dr. Michael Mina, chief science officer at biotech software company eMed, joins us to talk all things testing.

We talk about the latest COVID headlines, and take your calls, with Dr. Cassandra Pierre from Boston Medical Center and Dr. Simone Wildes, an infectious disease expert at South Shore Health.

We discuss the obvious and the not-so-obvious challenges brought on by the pandemic, how the need to pivot quickly to remote learning created opportunities to reexamine institutional priorities, and how we can use the lessons learned throughout the last two years to make a better, more equitable future moving forward.

We begin our special weeklong series, "Here's to you 2022." All week we'll have conversations that try to answer the question: What will make Greater Boston "greater" in 2022?

As part of a special weeklong series looking ahead at the year 2022, we dig into the region's health care system — and the short-term and long-term challenges it's facing over the next year.

We take your calls and discuss the issues that mean the most to your community with outgoing Boston City Councilor Andrea Campbell, and Tito Jackson, also a former Boston city councilor and the CEO of marijuana company Verdant Medical.

Huma Abedin is a longtime aide to Hillary Clinton, and her life story is complex. She went from a cloistered childhood spent in Saudi Arabia to the inner circle of the Clinton White House and then Hillary Clinton's campaigns.

Plus, we talk about the impact of the show "Pose" on local ballroom culture.

A special hour of Radio Boston, in which we revisit a January 2021 hour with four Black leaders on how they see Boston today and in the future.