No. 5 Indiana Hoosiers (+12.5) at No. 2 Ohio State Buckeyes, Noon ET, FOX
I’m doing a 180 on Indiana. I’ve doubted them before, but their perfect season has me more nervous about how they’ll perform as favorites rather than underdogs. Still, they have enough fight to stay within a dozen points.
Pick: Indiana +12.5
No. 9 Ole Miss Rebels (-10.5) at Florida Gators, Noon ET, ABC
The Gators capitalized on LSU mistakes last week, but DJ Lagway’s health and decision-making remain questionable. Ole Miss, with their consistent execution, should handle Florida comfortably.
Pick: Ole Miss -10.5
No. 13 SMU Mustangs (-9.5) at Virginia Cavaliers, Noon ET, ESPN2
Virginia’s push for bowl eligibility adds intrigue, but SMU has consistently won by multiple scores this season. They’re a playoff dark horse and should continue their dominance here.
Pick: SMU -9.5
No. 4 Penn State Nittany Lions (-12.5) at Minnesota Golden Gophers, 3:30 p.m. ET, CBS
Penn State is solid but not spectacular, and this matchup feels low-scoring. Minnesota’s defense should help them cover this sizable spread.
Pick: Minnesota +12.5
No. 14 BYU Cougars (+3.5) at No. 21 Arizona State Sun Devils, 3:30 p.m. ET, ESPN
BYU’s luck ran out last week, while Arizona State controls its Big 12 fate. With home-field advantage and a rising trajectory, the Sun Devils should prevail.
Pick: Arizona State -3.5
No. 16 Colorado Buffaloes (-3.5) at Kansas Jayhawks, 3:30 p.m. ET, FOX
Kansas delivered last week, and with a healthy Jalon Daniels, they can score with anyone. Expect another upset bid against Colorado.
Pick: Kansas +3.5
No. 19 Army Black Knights (+14.5) vs. No. 6 Notre Dame Fighting Irish (Yankee Stadium), 7:00 p.m. ET, NBC
Notre Dame has been dominant, but Army’s top-ranked scoring defense should make this a low-scoring, closer-than-expected contest.
Pick: Army +14.5
No. 12 Boise State Broncos (-23.5) at Wyoming Cowboys, 7:00 p.m. ET, CBSSN
Boise State is rolling, led by Jeanty’s dominance. Wyoming isn’t built to keep up with a top-tier team like this.
Pick: Boise State -23.5
No. 7 Alabama Crimson Tide (-14.5) at Oklahoma Sooners, 7:30 p.m. ET, ABC
Oklahoma’s postseason hopes depend on an upset. However, Alabama and Jalen Milroe present too much firepower for the Sooners to handle this week.
Pick: Alabama -14.5
No. 15 Texas A&M Aggies (-2.5) at Auburn Tigers, 7:30 p.m. ET, ESPN
This line is puzzling, but Auburn at home in a potential lookahead spot for Texas A&M makes them worth the pick.
Pick: Auburn +2.5
DK Saturday Main Slate DFS PicksRecord Year to Date: 19 Wins 25 Ties 21 Losses
Quarterback
Riley Leonard, Notre Dame ($9,500) – Leonard is a dual-threat QB with a high floor and ceiling against Virginia’s porous pass defense. He’s a great anchor for lineups with rushing TD upside.
Cade Klubnik, Clemson ($8,600) – Klubnik has rebounded nicely, with three TDs against Virginia Tech. Facing Pitt’s struggling secondary, he’s a safe pick with rushing upside.
Running Back
Isaac Brown, Louisville ($6,700) – Brown is mispriced for his role, averaging 24+ fantasy points. He thrives in Louisville’s run-heavy scheme and is a must-play against Stanford’s poor run defense.
Kaytron Allen, Penn State ($4,900) – If Nick Singleton sits, Allen becomes a lock for volume against Purdue. If Singleton plays, Allen still offers value but with limited exposure.
Wide Receiver
Will Sheppard, Colorado ($3,600) – Sheppard benefits from Colorado’s pass-heavy attack and has emerged as a value option with consistent targets and scoring potential.
TJ Moore, Clemson ($3,200) – Moore’s consistency and low price make him an ideal salary saver. He’s shown increased involvement and could be due for a breakout game.
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No. 5 Indiana Hoosiers (+12.5) at No. 2 Ohio State Buckeyes, Noon ET, FOX
I’m doing a 180 on Indiana. I’ve doubted them before, but their perfect season has me more nervous about how they’ll perform as favorites rather than underdogs. Still, they have enough fight to stay within a dozen points.
Pick: Indiana +12.5
No. 9 Ole Miss Rebels (-10.5) at Florida Gators, Noon ET, ABC
The Gators capitalized on LSU mistakes last week, but DJ Lagway’s health and decision-making remain questionable. Ole Miss, with their consistent execution, should handle Florida comfortably.
Pick: Ole Miss -10.5
No. 13 SMU Mustangs (-9.5) at Virginia Cavaliers, Noon ET, ESPN2
Virginia’s push for bowl eligibility adds intrigue, but SMU has consistently won by multiple scores this season. They’re a playoff dark horse and should continue their dominance here.
Pick: SMU -9.5
No. 4 Penn State Nittany Lions (-12.5) at Minnesota Golden Gophers, 3:30 p.m. ET, CBS
Penn State is solid but not spectacular, and this matchup feels low-scoring. Minnesota’s defense should help them cover this sizable spread.
Pick: Minnesota +12.5
No. 14 BYU Cougars (+3.5) at No. 21 Arizona State Sun Devils, 3:30 p.m. ET, ESPN
BYU’s luck ran out last week, while Arizona State controls its Big 12 fate. With home-field advantage and a rising trajectory, the Sun Devils should prevail.
Pick: Arizona State -3.5
No. 16 Colorado Buffaloes (-3.5) at Kansas Jayhawks, 3:30 p.m. ET, FOX
Kansas delivered last week, and with a healthy Jalon Daniels, they can score with anyone. Expect another upset bid against Colorado.
Pick: Kansas +3.5
No. 19 Army Black Knights (+14.5) vs. No. 6 Notre Dame Fighting Irish (Yankee Stadium), 7:00 p.m. ET, NBC
Notre Dame has been dominant, but Army’s top-ranked scoring defense should make this a low-scoring, closer-than-expected contest.
Pick: Army +14.5
No. 12 Boise State Broncos (-23.5) at Wyoming Cowboys, 7:00 p.m. ET, CBSSN
Boise State is rolling, led by Jeanty’s dominance. Wyoming isn’t built to keep up with a top-tier team like this.
Pick: Boise State -23.5
No. 7 Alabama Crimson Tide (-14.5) at Oklahoma Sooners, 7:30 p.m. ET, ABC
Oklahoma’s postseason hopes depend on an upset. However, Alabama and Jalen Milroe present too much firepower for the Sooners to handle this week.
Pick: Alabama -14.5
No. 15 Texas A&M Aggies (-2.5) at Auburn Tigers, 7:30 p.m. ET, ESPN
This line is puzzling, but Auburn at home in a potential lookahead spot for Texas A&M makes them worth the pick.
Pick: Auburn +2.5
DK Saturday Main Slate DFS PicksRecord Year to Date: 19 Wins 25 Ties 21 Losses
Quarterback
Riley Leonard, Notre Dame ($9,500) – Leonard is a dual-threat QB with a high floor and ceiling against Virginia’s porous pass defense. He’s a great anchor for lineups with rushing TD upside.
Cade Klubnik, Clemson ($8,600) – Klubnik has rebounded nicely, with three TDs against Virginia Tech. Facing Pitt’s struggling secondary, he’s a safe pick with rushing upside.
Running Back
Isaac Brown, Louisville ($6,700) – Brown is mispriced for his role, averaging 24+ fantasy points. He thrives in Louisville’s run-heavy scheme and is a must-play against Stanford’s poor run defense.
Kaytron Allen, Penn State ($4,900) – If Nick Singleton sits, Allen becomes a lock for volume against Purdue. If Singleton plays, Allen still offers value but with limited exposure.
Wide Receiver
Will Sheppard, Colorado ($3,600) – Sheppard benefits from Colorado’s pass-heavy attack and has emerged as a value option with consistent targets and scoring potential.
TJ Moore, Clemson ($3,200) – Moore’s consistency and low price make him an ideal salary saver. He’s shown increased involvement and could be due for a breakout game.
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