Florio & Simms make their weekly picks in a PFTPM/Unbuttoned collaboration. Can the Lions pull off the upset in Patrick Mahomes' first NFL game in a dome? Will Danny Dimes drop an L on the Redskins? And as always, the guys give their 3 Best Bets of the week.

(3:40) TNF: Eagles-Packers "Carson Wentz is the best QB the Packers have seen all year"

(9:30) Panthers-Texans "This is a chance for Houston to pull away in the AFC South"

(13:40) Browns-Ravens "I want to see how Freddie Kitchens handles adversity"

(19:55) Chiefs-Lions "If the Lions pull this off, it would be a shot heard 'around the NFL world"

(24:40) Chargers-Dolphins "I don't bet on bad teams"

(28:45) Patriots-Bills "Every we think this is the year the Bills stick it to the Patriots"

(36:00) Raiders-Colts "I think this Colts offense has gotten better every week"

(39:55) Titans-Falcons "The Titans always play to their competition"

(44:45) Redskins-Giants "I can't pick a team who stirs their Gatorade with a bag of plastic cups"

(54:55) Seahawks-Cardinals "The Seahawks need to keep pace in the NFC West"

(58:35) Buccaneers-Rams "There is something wrong with Todd Gurley"

(1:03:05) Jaguars-Broncos "I don't think Jalen Ramsey will play Sunday"

(1:07:50) Vikings-Bears "The Bears have never seen this version of Dalvin Cook"

(1:15:10) Cowboys-Saints "We have not seen a Cowboys offense like this in a long time"

(1:22:20) Bengals-Steelers "The Steelers are denial about not being good"

(1:26:55) Best Bets "Oh my gosh you are insane"