Florio & Simms do their weekly picks in a PFTPM/Unbuttoned collaboration. Have the Eagles and Saints found their groove? Will the Cowboys or Packers rebound from their first loss? And can the Colts get revenge in a playoff rematch at Arrowhead?

(3:55) TNF: Rams-Seahawks "The Rams offensive line is worse than we've seen in years"

(7:15) Jaguars-Panthers: "Kyle Allen has never started a home game"

(13:10) Cardinals-Bengals "It's not working for the Cardinals"

(16:25) Falcons-Texans "The Falcons should be 0-4"

(20:25) Buccaneers-Saints "I think the Saints are finding their groove with Teddy"

(24:05) Vikings-Giants "If it's a close game, you should pick the Giants to win"

(29:05) Bears-Raiders (in London) "Khalil Mack knows what it takes to break Derek Carr"

(33:20) Jets-Eagles "The Eagles are getting into their groove"

(36:50) Ravens-Steelers "I need to see this Steelers offense do it one more than once"

(41:05) Bills-Titans "The Titans lose when they're favorites and win when they're underdogs"

(44:35) Patriots-Redskins "This may be the dagger game for Jay Gruden"

(46:30) Broncos-Chargers "This is the kind of game the Chargers have to win"

(49:25) Cowboys-Packers "The Davante Adams injury has me concerned"

(52:45) Colts-Chiefs "At some point, the Chiefs defense has to stop something"

(55:55) Browns-49ers "I did something I've never done before when picking games"

(1:00:00) Best Bets "Someone called me the Mayor of Crazyville for picking the Giants last week"