On Monday night, the 49ers put on a running clinic in against the Cleveland Browns, but it ended up coming at a heavy cost: The team lost both their fullback and their right tackle to injury. Liz Loza and Matt Harmon open the show this week discussing the prospects of Matt Breida, Tevin Coleman and play a little game of either/or with the San Francisco backfield (2:06).

There's a lot to consider in Kansas City with now that the injury bug has shown its ugly head. With Sammy Watkins getting hurt and Tyreek Hill not yet ready to return, Byron Pringle emerged against the Colts — but is he the real deal – and does any of that matter if Patrick Mahomes is hobbled with an injured ankle (9:15)?

In other news, Chris Herndon made fantasy gamers rage uncontrollably after he hurt his hamstring in practice — and this is after waiting for him to return from his suspension. Not great. Liz & Matt break down the frustrating Jets offense and recommend some sage for Gang Green (15:45).

Oh, and Christian McCaffrey scared the sh** out of everybody by missing practice with a back issue but he returned to a full practice (thankfully). With that said, McCaffrey’s backup, Reggie Bonnafon, impressed late against the Jaguars, making him arguably the most valuable handcuff in fantasy (24:15).

Mark Walton got promoted after Kalen Ballage ... Kalen Ballage’d. Is Walton on the fantasy radar? What about the rest of the Dolphins, who are playing a must-lose game against Washington this week (31:30).

[Play in Yahoo’s NFL $300K Baller. $10 entry fee and $30K to first place]

After discussing all that, our experts preview a pair of sneaky-interesting Week 6 matchups in Houston/Kansas City and the London Bowl between the Panthers and Buccaneers (38:05), then wrap up the show giving some daily fantasy bargains and fades for the week (44:40).

Oh, and don’t forget to join the Week 6 NFL $300K Baller daily fantasy contest. Just a $10 entry fee! $30,000 to the first place winner!

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