There's a new headline going around claiming Ozempic might help with fertility — so Dr. Kelsy Vick (board-certified Doctor of Physical Therapy) went straight to the source: the actual research presented at ENDO 2026, the Endocrine Society's annual conference.
In this episode, we break down two separate findings — one in women with PMOS (formerly known as PCOS) and one in men — and what they actually mean. Spoiler: it's not "Ozempic cures infertility." It's something more specific, more mechanistic, and honestly more interesting than the headlines suggest.
We cover the RESTORE trial out of University of Colorado Anschutz and what it found about semaglutide, weight loss, and ovulation in women with PMOS. We also cover a separate UK-based review of male fertility data — including some genuinely surprising findings about sperm quality and testosterone. Plus, the bigger pattern connecting both: why metabolic health and reproductive health are far more linked than most people realize.
This episode is educational, not medical advice. If semaglutide and fertility are relevant to your life right now, this episode is designed to help you have a smarter, more informed conversation with your provider — not to replace one.
In this episode:
- What ENDO 2026 actually presented on semaglutide and fertility
- The connection between PMOS, insulin resistance, and ovulation
- What the RESTORE trial has found so far — and what it hasn't proven yet
- Surprising new data on GLP-1 medications and male fertility
- Why metabolic health and reproductive health are more connected than you think
- The honest caveats nobody's headline is including
New to PMOS? Go back and listen to our full deep-dive episode on the PCOS-to-PMOS renaming and what it means for diagnosis — linked below.
If this episode helped you make sense of the headlines, I'd love for you to leave a review — it helps another woman who needs to find this podcast.
102:: PCOS is dead. Meet the new & improved PMOS. https://player.captivate.fm/episode/f2f7f219-c9c5-46ae-8cd3-cb1f05467302/
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Resources
- Medical News Today (June 18, 2026) — Full reporting on both ENDO 2026 studies
- https://www.medicalnewstoday.com/articles/glp-1-drugs-show-promise-improving-fertility-males-females
- ENDO 2026 Conference Presentation — Male fertility & GLP-1 RAs
- https://endo2026.endocrine.org/fsPopup.asp?efp=RkVJT0NBS1UyNTg5OA&PresentationID=1843535&mode=presInfo
- Endocrine Society Press Release (2026) — GLP-1s and male fertility
- https://www.endocrine.org/news-and-advocacy/news-room/2026/natesh-press-release-endo-2026
- Fertility and Sterility — Semaglutide & PMOS reproductive outcomes (RESTORE trial preliminary analysis)
- https://www.sciencedirect.com/science/article/abs/pii/S0015028226004784
- RESTORE Trial — University of Colorado Anschutz / Cree Lab
- https://medschool.cuanschutz.edu/pediatrics/sections/endocrinology/endocrinology-research/cree-lab/research-projects