In October 2023, actor Matthew Perry died from the acute effects of drugs, with contributing factors including drowning, coronary artery disease, and the effects of buprenorphine. Investigations revealed that Perry's live-in assistant, Kenneth Iwamasa, had been administering ketamine injections to him multiple times daily in the days leading up to his death, despite lacking medical training. Iwamasa, along with two doctors—Dr. Mark Chavez and Dr. Salvador Plasencia—and two others, were charged in connection with Perry's death.