📈Our WYNDEX (What’s Your Number Index) update for today:

Markets were up this week, but the WYNDEX slipped again. Yonatan and Yael break down the biggest movers, including Nova leading the pack and monday.com falling to the bottom, plus what the Fed shakeup and a sudden drop in gold and silver signaled to investors.

🔎 Our Long Play Yonatan and Yael are joined by Daphne Koller, CEO and founder of insitro and co-founder of Coursera, for a wide-ranging conversation on insitro’s acquisition of CombinAble.AI. They explore why drug discovery still has a 90% failure rate, how AI can help uncover entirely new biological targets, what it takes to turn targets into real medicines, and why Israel’s talent ecosystem matters at the intersection of AI and biology.

This episode was sponsored by SAPIR: Sign up for the SAPIR journal at sapirjournal.org/whatsyournumber

01:00 - Numbers of the Week

05:00 - The Wyndex

10:40 - Big Short #1: Apple acquires Israeli startup Q.ai

14:40 - Big Short #2: United Nations financial crunch and global credibility

19:20 - Long Play: Daphne Koller on AI drug discovery

42:40 - Words of the Week

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New episodes drop on Wednesdays

LEGAL DISCLAIMER

This podcast offers general business and economic information and is not a comprehensive summary for investment decisions. It does not recommend or solicit any investment strategy or security. 

CREDITS:

Hosts - YONATAN ADIRI & YAEL WISSNER-LEVY

Executive Producer - ADAAM JAMES LEVIN-AREDDY

Production Manager - BRITTANY COHEN

Sound and Video editing - MARTIN HUERGO AND PATRICIO SPADAVECCHIA

Music - MIDNIGHT GENERATION

📈Our WYNDEX (What’s Your Number Index) update for today:

Markets moved higher this week, with the S&P up 0.73% and the NASDAQ up 1.55%, but the WYNDEX moved in the opposite direction, slipping 0.97%. Still, as January wraps up, the WYNDEX remains ahead, up 2.61% YTD compared to 1.12% for the NASDAQ and 1.02% for the S&P.

🔎 Our Long Play today takes a deep dive into Israel Aerospace Industries and the bigger question it raises about defense tech, ownership, and growth. Yael and Yonatan are joined by Natti Ginor, Managing Director and Head of Israel Investment Banking at Jefferies, to unpack reports that Israel Aerospace Industries is exploring an IPO. They explore IAI’s unique role as a government-owned defense giant, what going public would actually require, how global investors view Israeli defense tech, and who stands to win or lose if one of Israel’s most strategic companies makes the leap to the public markets.

This episode was sponsored by SAPIR: Sign up for the SAPIR journal at sapirjournal.org/whatsyournumber

01:12 – Numbers of the Week

03:43 – The Wyndex

05:21 – Big Short #1: Wix and the AI Talent Narrative

08:12 – Big Short #2: Lemonade, Tesla, and AI-Driven Insurance

10:56 – Long Play: Natti Ginor on Israel Aerospace Industries and a Potential IPO

35:12 – Words of the Week

Find us on:

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Yael on X

Yonatan on X

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A little bit of housekeeping:

Michal is away for the month of January. In her stead, Yonatan will be joined by the incomparable Yael Wissner-Levy, Chief Communications Officer at Tenzai, as co-host.

New episodes drop on Wednesdays

LEGAL DISCLAIMER

This podcast offers general business and economic information and is not a comprehensive summary for investment decisions. It does not recommend or solicit any investment strategy or security. 

CREDITS:

Hosts - YONATAN ADIRI & YAEL WISSNER-LEVY

Executive Producer - ADAAM JAMES LEVIN-AREDDY

Production Manager - BRITTANY COHEN

Sound and Video editing - MARTIN HUERGO

Music - MIDNIGHT GENERATION

📈Our WYNDEX (What’s Your Number Index) update for today:

Market weakness overall impacted the WYNDEX as well. Shedding 1% on a pretty flat S&P and a 0.26% decline in NASDAQ. 

🔎Our Long Play today looks at what happens to the economy as Israel emerges from the morass of war into the mess of an election year. With sights set on reelection, the policy makers in Jerusalem seem unwilling to stir the pot with dramatic-but-necessary reforms, opting instead for big headline-grabbing but fiscally irresponsible electioneering tactics. Yontatan and Yael unpack these developments and spotlight the winners and losers. They discuss how the current budget (or lack thereof), combined with reckless populist and a strong shekel, can increasingly burden Israel’s middle class and businesses. But on the bright side, getting a rideshare from the airport might become a lot easier soon. 

Find us on:

YouTube

Instagram

LinkedIn

Michal on X

Yonatan on X

Write to us here

A little bit of housekeeping:

Michal is away for the month of January. In her stead, Yonatan will be joined by the incomparable Yael Wissner-Levy, Chief Communications Officer at Tenzai, as co-host.

New episodes drop on Wednesdays

LEGAL DISCLAIMER

This podcast offers general business and economic information and is not a comprehensive summary for investment decisions. It does not recommend or solicit any investment strategy or security. 

CREDITS:

Hosts - YONATAN ADIRI & YAEL WISSNER-LEVY

Executive Producer - ADAAM JAMES LEVIN-AREDDY

Production Manager - BRITTANY COHEN

Sound and Video editing - MARTIN HUERGO

Music - MIDNIGHT GENERATION

📈Our WYNDEX (What’s Your Number Index) update for today:

WYNdex is back with a whopping 5.56% green performance, outperforming both S&P and NASDAQ by 4.59 and 4.71% respectively. Elbit, NOVA, Lemonade, and PANW in the green. EToro, FIVERR, and WIX in the red.

🔎Our Long Play today is a conversation with Ariel Karlinsky. Ariel, who’s a PhD student at Hebrew University’s economics department and the Center for the Study of Rationality, has recently co-authored a paper thoroughly examining how different populations in Israel engage with the welfare state. What makes a segment of the population a net contributor versus net dependent? His study reveals a stark reality: under the hood of Israel’s seemingly-robust economy there are actually 3 different economies: while one is highly productive and prosperous by first world standards, the other two resemble the developing world. Ariel, Yonatan, and Yael discuss: how did Israel get here? What happens if the incentives don’t change? And can Israel make the necessary reforms?

Read the paper here. On Taxes and Wonders: Complete Fiscal Accounts at the Household Level in Israel, published in the Israeli Economic Review, authored by Ariel Karlinsky, Tom Sadeh, Eran Yogev & Michael Sarel (2025).
 

Find us on:

YouTube

Instagram

LinkedIn

Michal on X

Yonatan on X

Write to us here

A little bit of housekeeping:

Michal is away for the month of January. In her stead, Yonatan will be joined by the incomparable Yael Wissner-Levy, Chief Communications Officer at Tenzai, as co-host.

New episodes drop on Wednesdays

LEGAL DISCLAIMER

This podcast offers general business and economic information and is not a comprehensive summary for investment decisions. It does not recommend or solicit any investment strategy or security. 

CREDITS:

Hosts - YONATAN ADIRI & YAEL WISSNER-LEVY

Executive Producer - ADAAM JAMES LEVIN-AREDDY

Production Manager - BRITTANY COHEN

Sound and Video editing - MARTIN HUERGO

Music - MIDNIGHT GENERATION

Our Long Play today is a conversation with Daniel Schreiber. In addition to being the co-founder and CEO of Lemonade, Daniel is the Founder and Chairman of the Mosaic Institute for AI Policy, an Israel-based nonprofit aiming to ensure that the AI revolution will be harnessed to shore up and grow the economy, rather than destroy it. With a look at history, Daniel, Yael, and Yonatan discuss how a future Israel economy might fare in an automated world between the risks of massive workforce displacement and the potential of turbocharged productivity.

Michal is away for the month of January. In her stead, Yonatan will be joined by Yael Wissner-Levy, Chief Communications Officer at Tenzai, as co-host.

LEGAL DISCLAIMER

This podcast offers general business and economic information and is not a comprehensive summary for investment decisions. It does not recommend or solicit any investment strategy or security. 

CREDITS:

Hosts - YONATAN ADIRI and MICHAL LEV-RAM

Guest host: YAEL WISSNER-LEVY

Executive Producer - ADAAM JAMES LEVIN-AREDDY

Production Manager - BRITTANY COHEN

Sound and Video editing - MARTIN HUERGO

Music - MIDNIGHT GENERATION

Find us on:

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📸 Instagram

💼 LinkedIn

𝕏 Michal on X

𝕏 Yonatan on X

📩 Write to us here

📈Our WYNDEX update for today:

It’s our last WYNDEX update of the year! On that note, here is our year-to-date comparison: 

WYNDEX - 20.78%

S&P - 15.77%

NASDAQ - 20.12%

Our best performers of the year were:

Lemonade with 125%

Elbit with almost 100%

Nova measurements up 64% 

TEVA up 24% (and is now a $35B company)

However, our WYN “babies” - the newcomers - were down for the year:

Etoro (~46% in the red) 

Via (32.74%).

Monday.com (35%) 

WIX was cut in half…

🔎And our Long Play today is a conversation with friend of the show investor Michael Eisenberg to talk about a recent piece he wrote in SAPIR Journal titled “Building Israel’s Trillion Dollar Economy.” Michael’s core argument is that Israel can (and must) double its GDP over the next 10 years, but that the growth drivers that got the economy to its current point won’t be enough to get it to this next milestone. We speak to Michael about his proposals and how he thinks Israel can continue to grow in the future. (And for more, please see the link to his article in SAPIR here: https://sapirjournal.org/money/2025/building-israels-trillion-dollar-economy/)

📅 New episodes drop every Wednesday

What’s Your Number? is hosted from Tel Aviv and Silicon Valley by Yonatan Adiri — Israeli entrepreneur and former advisor to President Shimon Peres — and Michal Lev-Ram, Israeli-born Silicon Valley-based tech journalist and contributing editor at Fortune. Together, they unpack the headlines, trends, and data driving Israel’s  economy and its future. 

⚖️ LEGAL DISCLAIMER

This podcast offers general business and economic information and is not a comprehensive summary for investment decisions. It does not recommend or solicit any investment strategy or security. 

🎧 CREDITS:

Hosts - YONATAN ADIRI and MICHAL LEV-RAM

Executive Producer - ADAAM JAMES LEVIN-AREDDY

Production Manager - BRITTANY COHEN

Sound and Video editing - MARTIN HUERGO

Music - MIDNIGHT GENERATION

Find us on:

📺 YouTube

📸 Instagram

💼 LinkedIn

𝕏 Michal on X

𝕏 Yonatan on X

📩 Write to us here

📈Our WYNDEX update for today:

The WYNDEX is down .8%, almost in line with the S&P and showing better performance than NASDAQ by 1.07%. Notable in the green this week is defense giant ELBIT with a 6.3% rise, completing a 99.5% increase year-to-date and trading at a $24 billion market cap. In the red we have ZIM, which continues to lose steam as it struggles to find a suitable acquirer, and eToro, which closed the week down 11.76% (40% below its IPO number). 

🔎And our Long Play today is a conversation with Natti Ginor, head of Israel Investment Banking at Jefferies. Last month, the investment firm - which is very active in the country - published a year-end report on the Israeli market called “Next-Gen Middle East: Israel’s role in shaping a tech future.” In this episode, we ask Natti to share some of the highlights of the report, giving listeners a snapshot not just of tech but overall market & economic fundamentals in Israel over the last year. 

📅 New episodes drop every Wednesday

What’s Your Number? is hosted from Tel Aviv and Silicon Valley by Yonatan Adiri — Israeli entrepreneur and former advisor to President Shimon Peres — and Michal Lev-Ram, Israeli-born Silicon Valley-based tech journalist and contributing editor at Fortune. Together, they unpack the headlines, trends, and data driving Israel’s  economy and its future. 

⚖️ LEGAL DISCLAIMER

This podcast offers general business and economic information and is not a comprehensive summary for investment decisions. It does not recommend or solicit any investment strategy or security. 

🎧 CREDITS:

Hosts - YONATAN ADIRI and MICHAL LEV-RAM

Executive Producer - ADAAM JAMES LEVIN-AREDDY

Sound and Video editing - MARTIN HUERGO

Music - MIDNIGHT GENERATION

Find us on:

📺 YouTube

📸 Instagram

💼 LinkedIn

𝕏 Michal on X

𝕏 Yonatan on X

📩 Write to us here

📈Our WYNDEX update for today:

The WYNDEX is back in the green for a second week in a row, up 3.29%, to be exact. That puts it ahead of both the S&P and NASDAQ (0.69 and 1.39%, respectively). Monday.com made a 9.09% jump back up after December 4th Guggenheim report with a Strong BUY ($250 target price). In the red is ZIM, which shed ~2% with a takeover bid by German Giant Hapag Lloyd competing with the Unger/management buyout offer which seems to lowball the market perception. Two cyber companies, Varonis and Sentinel One, were also down.

🎯Our Big Shorts for today:

• German Chancellor Friedrich Merz visited Israel this week. The European leader met with Prime Minister Netanyahu and other senior Israeli officials, and also spoke about that temporary & partial arms embargo on Israel, which Germany lifted last month once the ceasefire was in effect. We unpack the visit from this key partner.
• Eurovision decision: A decision has been made to allow Israel to stay in the 2026 competition. But several countries (including Spain, Ireland, the Netherlands) subsequently said they would boycott the competition as a result. What does this mean for Israeli isolation vs. integration as we move forward, and beyond the Eurovision itself?

🔎And our Long Play today is focused on Israel’s 2026 budget, which was passed by the cabinet just a few days ago. We’ll go over what you need to know - what’s in, what’s out, what’s controversial, etc. And what the next steps are for the budget. 

📅 New episodes drop every Wednesday

What’s Your Number? is hosted from Tel Aviv and Silicon Valley by Yonatan Adiri — Israeli entrepreneur and former advisor to President Shimon Peres — and Michal Lev-Ram, Israeli-born Silicon Valley-based tech journalist and contributing editor at Fortune. Together, they unpack the headlines, trends, and data driving Israel’s  economy and its future. 

⚖️ LEGAL DISCLAIMER

This podcast offers general business and economic information and is not a comprehensive summary for investment decisions. It does not recommend or solicit any investment strategy or security. 

🎧 CREDITS:

Hosts - YONATAN ADIRI and MICHAL LEV-RAM

Executive Producer - ADAAM JAMES LEVIN-AREDDY

Sound and Video editing - MARTIN HUERGO

Music - MIDNIGHT GENERATION

Find us on:

📺 YouTube

📸 Instagram

💼 LinkedIn

𝕏 Michal on X

𝕏 Yonatan on X

📩 Write to us here

📈Our WYNDEX update for today:

The WYNDEX bounced back 4.85% last week, beating both NASDAQ and S&P which were also in the green with a 3.20% and 3.93% rise, respectively. Notable stocks were Palo Alto Networks, which bounced back almost 4% alongside ZIM (+20%) and Lemonade (16%). The most interesting mover in this week’s WYNDEX was pharma giant TEVA with 11.07%. This was thanks to clinical approval of two biosimilar drugs the company can now bring to the market.

🔎Our Long Play today is an interview with Seth Siegel, a guest whose work has become essential reading for anyone trying to understand the future of water in the Middle East. Seth is a leading voice on water policy and innovation, and the author of several best-selling books, including Let There Be Water, the definitive account of how Israel became a global model for water management. He recently wrote an op-ed in the WSJ about Iran’s escalating water crisis and the role its hatred of Israel has played in bringing it to this moment. We talk to him about how water - perhaps more than any other resource - plays a critical role in the Middle East’s economic trajectory, and new innovations coming out of Israel. 

Here is the link to Seth’s recent op-ed in the WSJ: https://www.wsj.com/opinion/hatred-of-israel-caused-irans-water-crisis-4e566bac

And here is a link to his book, Let There Be Water: 

https://www.amazon.com/Let-There-Be-Water-Water-Starved/dp/1250115566

📅 New episodes drop every Wednesday

What’s Your Number? is hosted from Tel Aviv and Silicon Valley by Yonatan Adiri — Israeli entrepreneur and former advisor to President Shimon Peres — and Michal Lev-Ram, Israeli-born Silicon Valley-based tech journalist and contributing editor at Fortune. Together, they unpack the headlines, trends, and data driving Israel’s  economy and its future. 

⚖️ LEGAL DISCLAIMER

This podcast offers general business and economic information and is not a comprehensive summary for investment decisions. It does not recommend or solicit any investment strategy or security. 

🎧 CREDITS:

Hosts - YONATAN ADIRI and MICHAL LEV-RAM

Executive Producer - ADAAM JAMES LEVIN-AREDDY

Sound and Video editing - MARTIN HUERGO

Music - MIDNIGHT GENERATION

Find us on:

📺 YouTube

📸 Instagram

💼 LinkedIn

𝕏 Michal on X

𝕏 Yonatan on X

📩 Write to us here

📈Our WYNDEX update for today:

Not a good week for the WYNDEX! While the S&P and NASDAQ were also in the red last week (1.65% and 2.2%, respectively), the WYNDEX shed 7.7%. Some highlights: Palo Alto Networks lost 10.8% as the market did not react well to the cyber player’s acquisition of Chronosphere, and WIX and Monday.com shares were also down… no big moves in the green, sadly. 

🔎Our Long Play today is… a panel conversation that took place at the recent Z3 conference in Palo Alto, a one-day event that delves into world Jewry and Israel and the relationship between the two. There were lots of important conversations that took place at the conference… this one was about the economic relationship between the U.S. and Israel and how it’s changed over the last couple of years, plus of course what comes next. Speakers were: Omer Fein, Chief Economic Consul to the Western United States; Joy Sisisky, president and CEO of the Jewish Community Federation Bay Area; and Shaun Maguire, partner at Sequoia Capital. 

📅 New episodes drop every Wednesday

What’s Your Number? is hosted from Tel Aviv and Silicon Valley by Yonatan Adiri — Israeli entrepreneur and former advisor to President Shimon Peres — and Michal Lev-Ram, Israeli-born Silicon Valley-based tech journalist and contributing editor at Fortune. Together, they unpack the headlines, trends, and data driving Israel’s  economy and its future. 

⚖️ LEGAL DISCLAIMER

This podcast offers general business and economic information and is not a comprehensive summary for investment decisions. It does not recommend or solicit any investment strategy or security. 

🎧 CREDITS:

Hosts - YONATAN ADIRI and MICHAL LEV-RAM

Executive Producer - ADAAM JAMES LEVIN-AREDDY

Sound and Video editing - MARTIN HUERGO

Music - MIDNIGHT GENERATION