WolverHeme Happy Hour

By Bernard Marini, Anthony Perissinotti, et al.

Welcome to WolverHeme Happy Hour! This is a podcast dedicated to all things hematology! We discuss new data, debate controversial therapies, and talk about new and exciting research. While we nerd out... more

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FAQs about WolverHeme Happy Hour:

How many episodes does WolverHeme Happy Hour have?

The podcast currently has 37 episodes available.

WolverHeme Happy Hour episodes:

August 28, 2024 Houston, we don't have a problem... with APOLLO
In this episode, Anthony and Bernie discuss the recently reported APOLLO trial in high-risk APL and debate whether this should represent the new standard of care in this population. We also review key practical considerations for the treatment of APL patients, including side effect management and treatment of APL in unique clinical scenarios.

APOLLO: https://library.ehaweb.org/eha/2024/eha2024-congress/422206/uwe.platzbecker.first.results.of.the.apollo.trial.a.randomized.phase.iii.study.html
...more
59min
June 13, 2024 From Ancient Remedies to Modern Miracles: The Evolution of APL Treatment
In this episode, Bernie and Anthony review the full history of APL treatment, in preparation for the upcoming plenary presentation of the APOLLO study THIS WEEKEND at EHA 2024!

How did we get to our current standard of care in APL? How and why did the PETHEMA, GIMEMA, UK MRC, and other cooperative group regimens evolve over time into what they are today?

And importantly, is the APOLLO control arm (no arsenic!), ok? Tune in to find out!
...more
59min
April 17, 2024 Episode 24: Myeloma Madness with the Myeloma Man
In this episode, Anthony and Bernie are joined by Multiple Myeloma expert Dr. Manni Mohyuddin, to discuss the recent FDA approval updates of CAR-T in this disease state. We also discuss the hotly debated topic of MRD as a surrogate endpoint for accelerated approval in Myeloma.
...more
59min
January 25, 2024Anthony and Bernie get rich on no-larabine! An ASH 2023 ALL discussion
In this episode, Anthony and Bernie review the most impactful and interesting ALL abstracts at the 2023 ASH Annual Meeting. We dive into the nelarabine abstracts, calaspargase (cal-peg), and the evolution of the treatment of Ph+ ALL!

Abstracts discussed:
https://ash.confex.com/ash/2023/webprogram/Paper190141.html - COG AYA Outcomes (and silly nelarabine conclusions)

https://ash.confex.com/ash/2023/webprogram/Paper177696.html - ATRIALL Nelarabine study

https://ash.confex.com/ash/2023/webprogram/Paper179562.html - HyperCVAD + Nelarabine + PEG + venetoclax

https://ash.confex.com/ash/2023/webprogram/Paper179192.html - ALL-TARGET Study in R/R T-ALL

https://ash.confex.com/ash/2023/webprogram/Paper187694.html - Cal-PEG is toxic

https://ash.confex.com/ash/2023/webprogram/Paper188064.html - Ponatinib + Blinatumomab

https://ash.confex.com/ash/2023/webprogram/Paper187773.html - D-ALBA (Dasatinib + Blinatumomab)

https://ash.confex.com/ash/2023/webprogram/Paper189632.html - GIMEMA (Dasatinib or Ponatinib + Blinatumomab)
...more
58min
December 29, 2023LymphOMG: Pouring Over Lymphoma Abstracts from ASH
OMG! In this extra fun holiday episode, we are joined by lymphoma experts Tycel Phillips and Aaron Goodman to review the most impactful and controversial lymphoma abstracts from ASH! Stay tuned for a lively discussion!

Abstracts Discussed!
SYMPATICO (Ibrutinib + Ven in R/R MCL):
https://ash.confex.com/ash/2023/webprogram/Paper191921.html

Nivo-AVD in elderly Hodgkin Lymphoma:
https://ash.confex.com/ash/2023/webprogram/Paper180114.html

BOVEN - Zanubrutinib + Obi + Ven in TP53 mutant MCL:
https://ash.confex.com/ash/2023/webprogram/Paper180069.html

CAR-T in CNS Lymphoma:
https://ash.confex.com/ash/2023/webprogram/Paper174883.html (EBMT data),
https://ash.confex.com/ash/2023/webprogram/Paper184345.html (Multicenter retrospective study)

Synthetic Control Arms:
https://ash.confex.com/ash/2023/webprogram/Paper177708.html

POLARIX Subgroup Analysis (shout out to the Blood Cancer Talks crew!):
https://x.com/Eddie_Cliff/status/1733901400822993257?s=20
...more
1h 13min
December 19, 2023AMLchemy at ASH: Brewing Success with Menin Magic, MRD Mysteries, and Aza/Ven Alchemy
In this episode, Anthony and Bernie discuss the AML abstracts at ASH that we found most intriguing and controversial!
Abstracts:
FILO - Stopping Aza/Ven: https://ash.confex.com/ash/2023/webprogram/Paper185437.html

Revumenib Late Breaking Abstract:
https://ash.confex.com/ash/2023/webprogram/Paper192042.html

JNJ617 Menin Inhibitor Data:
https://ash.confex.com/ash/2023/webprogram/Paper172422.html

SAVE Trial (Revumenib + PO Dec/ven):
https://ash.confex.com/ash/2023/webprogram/Paper182337.html

Dec/Ven vs. 3+7 Randomized Phase II:
https://ash.confex.com/ash/2023/webprogram/Paper181347.html

NCRI AML18 RCT:
https://ash.confex.com/ash/2023/webprogram/Paper185956.html

Impact of NPM1+/FLT3+/MRD in AML17 and AML19:
https://ash.confex.com/ash/2023/webprogram/Paper179033.html

CBF and NPM1 MRD:
https://ash.confex.com/ash/2023/webprogram/Paper184848.html

Persistent MRD by PCR but Flow Negativity in CBF AML (Mast Cell Madness):
https://ash.confex.com/ash/2023/webprogram/Paper180275.html

MORPHO More MRD Analysis:
https://ash.confex.com/ash/2023/webprogram/Paper177929.html
...more
42min
December 01, 2023ASH Pregaming - Myeloma Madness with Manni and Papa Heme
In this episode, Anthony and Bernie are joined by two very special guests - Dr. Aaron "Papa Heme" Goodman and Dr. Manni "Myeloma Man" Mohyuddin - to discuss the most interesting myeloma abstracts at the upcoming 2023 ASH meeting! Will any of these change practice? Listen to find out!

Abstracts Discussed:
https://ash.confex.com/ash/2023/webprogram/Paper188547.html

https://ash.confex.com/ash/2023/webprogram/Paper181765.html

https://ash.confex.com/ash/2023/webprogram/Paper177954.html

https://ash.confex.com/ash/2023/webprogram/Paper191911.html

https://ash.confex.com/ash/2023/webprogram/Paper179866.html

https://ash.confex.com/ash/2023/webprogram/Paper177546.html

https://ash.confex.com/ash/2023/webprogram/Paper178835.html

Also check out Manni's excellent tweetorial on some of these key abstracts:
https://x.com/ManniMD1/status/1726980328559133028?s=20
...more
53min
November 08, 2023AML Maintenance Part 2: a metaMORPHOsis?
In the second portion of our two part-series on AML maintenance, Anthony and Bernie delve into the studies of post-transplant FLT3 inhibitor maintenance. We discuss the controversial MORPHO study of gilteritinib and whether these results will change practice!
Sorafenib observational study: https://pubmed.ncbi.nlm.nih.gov/30809038/

SORMAIN (sorafenib): https://pubmed.ncbi.nlm.nih.gov/32673171/

Chinese Sorafenib Phase III: https://pubmed.ncbi.nlm.nih.gov/32791048/

RADIUS (midostaurin): https://pubmed.ncbi.nlm.nih.gov/33288862/

AMLSG 16-10 (midostaurin): https://pubmed.ncbi.nlm.nih.gov/30563875/

MORPHO (EHA abstract): https://library.ehaweb.org/eha/2023/eha2023-congress/391322/faculty.presenters.bmt-ctn.1506.28morpho29.a.randomized.trial.of.the.flt3.html?f=listing%3D0%2Abrowseby%3D8%2Asortby%3D1%2Asearch%3Dmorpho
...more
55min
October 25, 2023AML Maintenance Part 1: Set Your QUAZARs to Stun
In the first of a two part-series, Anthony and Bernie dive into the data surrounding maintenance therapies in AML. This episode focuses on maintenance therapy for patients ineligible for transplant, with a focus on oral azacitidine and the controversial QUAZAR study.

Key References:
QUAZAR AML-001: https://pubmed.ncbi.nlm.nih.gov/33369355/

QUAZAR Letter to the Editor: https://pubmed.ncbi.nlm.nih.gov/33789022/
ASH Abstract Data on impact of # of Consolidation Cycles: https://ash.confex.com/ash/2020/webprogram/Paper138498.html

Hovon 97 (Azacitidine SQ maintenance): https://pubmed.ncbi.nlm.nih.gov/30630862/
Mayer, et al. NEJM. 1994. (CALGB HiDAC consolidation): https://pubmed.ncbi.nlm.nih.gov/8078551/

Büchner, et al. JCO. 1985: https://pubmed.ncbi.nlm.nih.gov/3906048/
...more
52min
August 23, 2023 Episode 17: The Hemophilia Eras Tour
In this episode, we are joined by classical hematology experts, Madeleine Ochs, PharmD, BCOP and Justin Arnall, PharmD, BCOP, to teach us hemophilia 101!
In this T-Swift themed, episode, we discuss the history of hemophilia treatment (through the "eras") and how new agents may change the management of hemophilia patients.
...more
1h 40min

FAQs about WolverHeme Happy Hour:

How many episodes does WolverHeme Happy Hour have?

The podcast currently has 37 episodes available.

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